MUC20 (mucin 20, cell surface associated)

2014-01-01  

Identity

HGNC
LOCATION
3q29
LOCUSID
ALIAS
MUC-20

Other Information

Locus ID:

NCBI: 200958
MIM: 610360
HGNC: 23282
Ensembl: ENSG00000176945

Variants:

dbSNP: 200958
ClinVar: 200958
TCGA: ENSG00000176945
COSMIC: MUC20

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000176945ENST00000320736E9PH32
ENSG00000176945ENST00000423938H7C102
ENSG00000176945ENST00000436408C9JJE7
ENSG00000176945ENST00000445522Q8N307
ENSG00000176945ENST00000447234Q8N307

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
O-linked glycosylationREACTOMER-HSA-5173105
O-linked glycosylation of mucinsREACTOMER-HSA-913709
Termination of O-glycan biosynthesisREACTOMER-HSA-977068
DiseaseREACTOMER-HSA-1643685
Diseases of glycosylationREACTOMER-HSA-3781865
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
C-type lectin receptors (CLRs)REACTOMER-HSA-5621481
Dectin-2 familyREACTOMER-HSA-5621480
Signal TransductionREACTOMER-HSA-162582
Diseases associated with O-glycosylation of proteinsREACTOMER-HSA-3906995
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)REACTOMER-HSA-5083632
Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)REACTOMER-HSA-5083625
Defective GALNT12 causes colorectal cancer 1 (CRCS1)REACTOMER-HSA-5083636
Signaling by METREACTOMER-HSA-6806834
MET activates RAS signalingREACTOMER-HSA-8851805

References

Pubmed IDYearTitleCitations
237870192013Role of MUC20 overexpression as a predictor of recurrence and poor outcome in colorectal cancer.14
153141562004MUC20 suppresses the hepatocyte growth factor-induced Grb2-Ras pathway by binding to a multifunctional docking site of met.13
188340732008Mucin gene expression in human laryngeal epithelia: effect of laryngopharyngeal reflux.10
251689022014Expression analysis of the transmembrane mucin MUC20 in human corneal and conjunctival epithelia.8
267700202015Differential Expression of MUC12, MUC16, and MUC20 in Patients with Active and Remission Ulcerative Colitis.8
266162262016MUC20 promotes aggressive phenotypes of epithelial ovarian cancer cells via activation of the integrin β1 pathway.7
302361272018Integrative analysis of the cancer genome atlas and cancer cell lines encyclopedia large-scale genomic databases: MUC4/MUC16/MUC20 signature is associated with poor survival in human carcinomas.5
165082462006Tandem repeats polymorphism of MUC20 is an independent factor for the progression of immunoglobulin A nephropathy.4
266738202016Possible prediction of the response of esophageal squamous cell carcinoma to neoadjuvant chemotherapy based on gene expression profiling.4
160296332005[Variable number of tandem repeats polymorphism of MUC20 is associated with the progression of IgA nephropathy].2

Citation

Dessen P

MUC20 (mucin 20, cell surface associated)

Atlas Genet Cytogenet Oncol Haematol. 2014-01-01

Online version: http://atlasgeneticsoncology.org/gene/53678/muc20