MUC3A (mucin 3A, cell surface associated)

2003-02-01  

Identity

HGNC
MUC3A
LOCATION
7q22.1
LOCUSID
4584
ALIAS
MUC-3A,MUC3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4584
MIM: 158371
HGNC: 7513
Ensembl: ENSG00000169894

Variants:

dbSNP: 4584
ClinVar: 4584
TCGA: ENSG00000169894
COSMIC: MUC3A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000169894ENST00000379458Q02505
ENSG00000169894ENST00000414964A0A182DWF7
ENSG00000169894ENST00000483366Q02505

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
O-linked glycosylationREACTOMER-HSA-5173105
O-linked glycosylation of mucinsREACTOMER-HSA-913709
Termination of O-glycan biosynthesisREACTOMER-HSA-977068
DiseaseREACTOMER-HSA-1643685
Diseases of glycosylationREACTOMER-HSA-3781865
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
C-type lectin receptors (CLRs)REACTOMER-HSA-5621481
Dectin-2 familyREACTOMER-HSA-5621480
Diseases associated with O-glycosylation of proteinsREACTOMER-HSA-3906995
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)REACTOMER-HSA-5083632
Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)REACTOMER-HSA-5083625
Defective GALNT12 causes colorectal cancer 1 (CRCS1)REACTOMER-HSA-5083636

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
187900502008Cell surface glyceraldehyde-3-phosphate dehydrogenase (GAPDH) of Lactobacillus plantarum LA 318 recognizes human A and B blood group antigens.16
205108742010Promoter hypomethylation contributes to the expression of MUC3A in cancer cells.11
188340732008Mucin gene expression in human laryngeal epithelia: effect of laryngopharyngeal reflux.10
193658372009Pseudocyst of the pancreas: the role of cytology and special stains for mucin.6
145504702003Quantitative RT-PCR assay for MUC3 and VEGF mRNA in renal clear cell carcinoma: relationship with nuclear grade and prognosis.4
273741812016Increased expression of MUC3A is associated with poor prognosis in localized clear-cell renal cell carcinoma.4
302600462019MSLN (Mesothelin), ANTXR1 (TEM8), and MUC3A are the potent antigenic targets for CAR T cell therapy of gastric adenocarcinoma.4
181635202008Expression of mucin 3 and mucin 5AC in arthritic synovial tissue.3
129583102003Initiation of transcription of the MUC3A human intestinal mucin from a TATA-less promoter and comparison with the MUC3B amino terminus.2
193658342009A technique to improve diagnostic information from fine-needle aspirations: immunohistochemistry on cytoscrape.0

Citation

Dessen P

MUC3A (mucin 3A, cell surface associated)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41458/muc3a