MUC5B (mucin 5B, oligomeric mucus/gel-forming)

2003-02-01  

Identity

HGNC
LOCATION
11p15.5
LOCUSID
ALIAS
MG1,MUC-5B,MUC5,MUC9
FUSION GENES

Other Information

Locus ID:

NCBI: 727897
MIM: 600770
HGNC: 7516
Ensembl: ENSG00000117983

Variants:

dbSNP: 727897
ClinVar: 727897
TCGA: ENSG00000117983
COSMIC: MUC5B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000117983ENST00000526859H0YDX8
ENSG00000117983ENST00000529681Q9HC84

Expression (GTEx)

0
100
200
300
400
500
600
700

Pathways

PathwaySourceExternal ID
Salivary secretionKEGGko04970
Salivary secretionKEGGhsa04970
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
O-linked glycosylationREACTOMER-HSA-5173105
O-linked glycosylation of mucinsREACTOMER-HSA-913709
Termination of O-glycan biosynthesisREACTOMER-HSA-977068
DiseaseREACTOMER-HSA-1643685
Diseases of glycosylationREACTOMER-HSA-3781865
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
C-type lectin receptors (CLRs)REACTOMER-HSA-5621481
Dectin-2 familyREACTOMER-HSA-5621480
Diseases associated with O-glycosylation of proteinsREACTOMER-HSA-3906995
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)REACTOMER-HSA-5083632
Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)REACTOMER-HSA-5083625
Defective GALNT12 causes colorectal cancer 1 (CRCS1)REACTOMER-HSA-5083636
IL-17 signaling pathwayKEGGko04657
IL-17 signaling pathwayKEGGhsa04657

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
177034122007Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.100
235270032013The idiopathic pulmonary fibrosis honeycomb cyst contains a mucocilary pseudostratified epithelium.71
237833742013Expression of cilium-associated genes defines novel molecular subtypes of idiopathic pulmonary fibrosis.64
263319422015TOLLIP, MUC5B, and the Response to N-Acetylcysteine among Individuals with Idiopathic Pulmonary Fibrosis.49
174712372007Epigenetic regulation (DNA methylation, histone modifications) of the 11p15 mucin genes (MUC2, MUC5AC, MUC5B, MUC6) in epithelial cancer cells.43
238077792013Expression of MUC2, MUC5AC, MUC5B, and MUC6 mucins in colorectal cancers and their association with the CpG island methylator phenotype.43
149880812004MUC5AC and MUC5B Mucins Are Decreased in Cystic Fibrosis Airway Secretions.33
187573072009Hyaluronan fragments/CD44 mediate oxidative stress-induced MUC5B up-regulation in airway epithelium.29
278455892016Abnormalities in MUC5AC and MUC5B Protein in Airway Mucus in Asthma.29
192589232009Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes.26

Citation

Dessen P

MUC5B (mucin 5B, oligomeric mucus/gel-forming)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41461/muc5b