MUS81 (MUS81 structure-specific endonuclease subunit)

2004-06-01  

Identity

HGNC
LOCATION
11q13.1
LOCUSID
ALIAS
SLX3
FUSION GENES

Other Information

Locus ID:

NCBI: 80198
MIM: 606591
HGNC: 29814
Ensembl: ENSG00000172732

Variants:

dbSNP: 80198
ClinVar: 80198
TCGA: ENSG00000172732
COSMIC: MUS81

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000172732ENST00000308110Q96NY9
ENSG00000172732ENST00000524647H0YDE3
ENSG00000172732ENST00000525768E9PL60
ENSG00000172732ENST00000529374H0YDU2
ENSG00000172732ENST00000529742H0YE94
ENSG00000172732ENST00000529857E9PII7
ENSG00000172732ENST00000530111H0YDK3
ENSG00000172732ENST00000533035E9PRI1

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Homologous recombinationKEGGko03440
Homologous recombinationKEGGhsa03440
Fanconi anemia pathwayKEGGko03460
Fanconi anemia pathwayKEGGhsa03460
DNA RepairREACTOMER-HSA-73894
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
Homology Directed RepairREACTOMER-HSA-5693538
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)REACTOMER-HSA-5693567
HDR through Homologous Recombination (HRR)REACTOMER-HSA-5685942
Resolution of D-Loop StructuresREACTOMER-HSA-5693537
Resolution of D-loop Structures through Holliday Junction IntermediatesREACTOMER-HSA-5693568
Fanconi Anemia PathwayREACTOMER-HSA-6783310

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
379535552023A study of protective effects of Mus81 in preeclampsia.0
379535552023A study of protective effects of Mus81 in preeclampsia.0
352907972022Crystal structure of the human MUS81-EME2 complex.3
352907972022Crystal structure of the human MUS81-EME2 complex.3
334316682021ATRX and RECQ5 define distinct homologous recombination subpathways.18
342723852021Abraxas suppresses DNA end resection and limits break-induced replication by controlling SLX4/MUS81 chromatin loading in response to TOP1 inhibitor-induced DNA damage.9
334316682021ATRX and RECQ5 define distinct homologous recombination subpathways.18
342723852021Abraxas suppresses DNA end resection and limits break-induced replication by controlling SLX4/MUS81 chromatin loading in response to TOP1 inhibitor-induced DNA damage.9
324193012020Homologous recombination and Mus81 promote replication completion in response to replication fork blockage.25
332984412020Mus81-Eme1-dependent aberrant processing of DNA replication intermediates in mitosis impairs genome integrity.19
324193012020Homologous recombination and Mus81 promote replication completion in response to replication fork blockage.25
332984412020Mus81-Eme1-dependent aberrant processing of DNA replication intermediates in mitosis impairs genome integrity.19
311149102019RAD51 and mitotic function of mus81 are essential for recovery from low-dose of camptothecin in the absence of the WRN exonuclease.7
311426622019The DNA Endonuclease Mus81 Regulates ZEB1 Expression and Serves as a Target of BET4 Inhibitors in Gastric Cancer.8
311149102019RAD51 and mitotic function of mus81 are essential for recovery from low-dose of camptothecin in the absence of the WRN exonuclease.7

Citation

Dessen P

MUS81 (MUS81 structure-specific endonuclease subunit)

Atlas Genet Cytogenet Oncol Haematol. 2004-06-01

Online version: http://atlasgeneticsoncology.org/gene/42907/mus81