MUS81 (MUS81 structure-specific endonuclease subunit)

2004-06-01 Affiliation

Identity

HGNC

MUS81

LOCATION

11q13.1

LOCUSID

80198

ALIAS

SLX3

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 80198
MIM: 606591
HGNC: 29814
Ensembl: ENSG00000172732

Variants:

dbSNP: 80198
ClinVar: 80198
TCGA: ENSG00000172732
COSMIC: MUS81

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000172732	ENST00000308110	Q96NY9
ENSG00000172732	ENST00000524647	H0YDE3
ENSG00000172732	ENST00000525768	E9PL60
ENSG00000172732	ENST00000529374	H0YDU2
ENSG00000172732	ENST00000529742	H0YE94
ENSG00000172732	ENST00000529857	E9PII7
ENSG00000172732	ENST00000530111	H0YDK3
ENSG00000172732	ENST00000533035	E9PRI1

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Homologous recombination	KEGG	ko03440
Homologous recombination	KEGG	hsa03440
Fanconi anemia pathway	KEGG	ko03460
Fanconi anemia pathway	KEGG	hsa03460
DNA Repair	REACTOME	R-HSA-73894
DNA Double-Strand Break Repair	REACTOME	R-HSA-5693532
Homology Directed Repair	REACTOME	R-HSA-5693538
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)	REACTOME	R-HSA-5693567
HDR through Homologous Recombination (HRR)	REACTOME	R-HSA-5685942
Resolution of D-Loop Structures	REACTOME	R-HSA-5693537
Resolution of D-loop Structures through Holliday Junction Intermediates	REACTOME	R-HSA-5693568
Fanconi Anemia Pathway	REACTOME	R-HSA-6783310

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
17934473	2007	The structure-specific endonuclease Mus81 contributes to replication restart by generating double-strand DNA breaks.	182
24076221	2013	Coordinated actions of SLX1-SLX4 and MUS81-EME1 for Holliday junction resolution in human cells.	104
23811685	2013	MUS81 promotes common fragile site expression.	101
27984745	2016	RAD52 Facilitates Mitotic DNA Synthesis Following Replication Stress.	88
29035360	2017	EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation.	69
22123861	2011	Mus81-mediated DNA cleavage resolves replication forks stalled by topoisomerase I-DNA complexes.	68
21859861	2011	Wee1 controls genomic stability during replication by regulating the Mus81-Eme1 endonuclease.	66
12374758	2002	Holliday junction resolution in human cells: two junction endonucleases with distinct substrate specificities.	64
24080495	2013	Human GEN1 and the SLX4-associated nucleases MUS81 and SLX1 are essential for the resolution of replication-induced Holliday junctions.	61
18852298	2008	Replication fork stalling in WRN-deficient cells is overcome by prompt activation of a MUS81-dependent pathway.	50

Citation

Dessen P

MUS81 (MUS81 structure-specific endonuclease subunit)

Atlas Genet Cytogenet Oncol Haematol. 2004-06-01

Online version: http://atlasgeneticsoncology.org/gene/42907/mus81