MXD1 (MAX dimerization protein 1)

2003-02-01  

Identity

HGNC
LOCATION
2p13.3
LOCUSID
ALIAS
BHLHC58,MAD,MAD1
FUSION GENES

Other Information

Locus ID:

NCBI: 4084
MIM: 600021
HGNC: 6761
Ensembl: ENSG00000059728

Variants:

dbSNP: 4084
ClinVar: 4084
TCGA: ENSG00000059728
COSMIC: MXD1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000059728ENST00000264444Q05195
ENSG00000059728ENST00000409442F8WBI0
ENSG00000059728ENST00000435990C9JBE8
ENSG00000059728ENST00000540449Q05195

Expression (GTEx)

0
50
100
150
200
250
300
350

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
125539082003X-ray structures of Myc-Max and Mad-Max recognizing DNA. Molecular bases of regulation by proto-oncogenic transcription factors.172
184510272008Activation of PI3K/Akt and MAPK pathways regulates Myc-mediated transcription by phosphorylating and promoting the degradation of Mad1.78
152825432004MAD1 and c-MYC regulate UBF and rDNA transcription during granulocyte differentiation.62
246754622014MiR-19a/b modulate the metastasis of gastric cancer cells by targeting the tumour suppressor MXD1.55
152355942004HBP1 and Mad1 repressors bind the Sin3 corepressor PAH2 domain with opposite helical orientations.36
128241802003Mad upregulation and Id2 repression accompany transforming growth factor (TGF)-beta-mediated epithelial cell growth suppression.28
256116992015Down regulation of miR-202 modulates Mxd1 and Sin3A repressor complexes to induce apoptosis of pancreatic cancer cells.14
197661142009TGF-beta enforces senescence in Myc-transformed hematopoietic tumor cells through induction of Mad1 and repression of Myc activity.12
195264592009The suppression of MAD1 by AKT-mediated phosphorylation activates MAD1 target genes transcription.11
170827802006Proteomic discovery of Max as a novel interacting partner of C/EBPalpha: a Myc/Max/Mad link.7

Citation

Dessen P

MXD1 (MAX dimerization protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/214/mxd1