MYH10 (myosin heavy chain 10)

2003-02-01  

Identity

HGNC
LOCATION
17p13.1
LOCUSID
ALIAS
NMMHC-IIB,NMMHCB
FUSION GENES

Other Information

Locus ID:

NCBI: 4628
MIM: 160776
HGNC: 7568
Ensembl: ENSG00000133026

Variants:

dbSNP: 4628
ClinVar: 4628
TCGA: ENSG00000133026
COSMIC: MYH10

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000133026ENST00000269243P35580
ENSG00000133026ENST00000360416P35580
ENSG00000133026ENST00000379980P35580
ENSG00000133026ENST00000411957E7ERA5

Expression (GTEx)

0
100
200
300
400
500
600
700
800
900
1000

Pathways

PathwaySourceExternal ID
Tight junctionKEGGko04530
Regulation of actin cytoskeletonKEGGko04810
Tight junctionKEGGhsa04530
Regulation of actin cytoskeletonKEGGhsa04810
Salmonella infectionKEGGko05132
Salmonella infectionKEGGhsa05132
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ROCKsREACTOMER-HSA-5627117
RHO GTPases activate PAKsREACTOMER-HSA-5627123
RHO GTPases activate PKNsREACTOMER-HSA-5625740
RHO GTPases activate CITREACTOMER-HSA-5625900
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Semaphorin interactionsREACTOMER-HSA-373755
Sema4D in semaphorin signalingREACTOMER-HSA-400685
Sema4D induced cell migration and growth-cone collapseREACTOMER-HSA-416572
EPH-Ephrin signalingREACTOMER-HSA-2682334
EPHA-mediated growth cone collapseREACTOMER-HSA-3928663

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
127041892003Kinetic mechanism of non-muscle myosin IIB: functional adaptations for tension generation and maintenance.112
231282392012Crawling from soft to stiff matrix polarizes the cytoskeleton and phosphoregulates myosin-II heavy chain.102
154964542005Anillin binds nonmuscle myosin II and regulates the contractile ring.97
170208812006Rho kinase differentially regulates phosphorylation of nonmuscle myosin II isoforms A and B during cell rounding and migration.90
240727162013Characterization of three full-length human nonmuscle myosin II paralogs.75
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
158455342005Disease-associated mutations and alternative splicing alter the enzymatic and motile activity of nonmuscle myosins II-B and II-C.60
192376612009Cardiac myosin binding protein-C phosphorylation in a {beta}-myosin heavy chain background.53
166117442006PAK1 and aPKCzeta regulate myosin II-B phosphorylation: a novel signaling pathway regulating filament assembly.43
263683112015Feedback regulation through myosin II confers robustness on RhoA signalling at E-cadherin junctions.41

Citation

Dessen P

MYH10 (myosin heavy chain 10)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41478/myh10