MYL1 (myosin light chain 1)

2008-07-01  

Identity

HGNC
LOCATION
2q34
LOCUSID
ALIAS
MLC1F,MLC3F,MYOFTA
FUSION GENES

Other Information

Locus ID:

NCBI: 4632
MIM: 160780
HGNC: 7582
Ensembl: ENSG00000168530

Variants:

dbSNP: 4632
ClinVar: 4632
TCGA: ENSG00000168530
COSMIC: MYL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168530ENST00000341685P05976
ENSG00000168530ENST00000352451P05976

Expression (GTEx)

0
500
1000
1500
2000
2500
3000
3500

Pathways

PathwaySourceExternal ID
Muscle contractionREACTOMER-HSA-397014
Striated Muscle ContractionREACTOMER-HSA-390522

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
217317512011Inhibition of MLC phosphorylation restricts replication of influenza virus--a mechanism of action for anti-influenza agents.17
205188492011Ischemia induced peroxynitrite dependent modifications of cardiomyocyte MLC1 increases its degradation by MMP-2 leading to contractile dysfunction.16
284279972017Distinct sequences and post-translational modifications in cardiac atrial and ventricular myosin light chains revealed by top-down mass spectrometry.9
233195952013The MLK-related kinase (MRK) is a novel RhoC effector that mediates lysophosphatidic acid (LPA)-stimulated tumor cell invasion.7
302157112018Bi-allelic mutations in MYL1 cause a severe congenital myopathy.7
221313512012Mutations of ventricular essential myosin light chain disturb myosin binding and sarcomeric sorting.4
260114492015Src Family Kinases (SFK) Mediate Angiotensin II-Induced Myosin Light Chain Phosphorylation and Hypertension.4
286186532017Myosin regulatory light chain phosphorylation is associated with leiomyosarcoma development.3
264734452017Intron polymorphism in MYL1 gene is associated with individual cardiac trainability to endurance training in human myocardium.2
291026342018Transient interaction between the N-terminal extension of the essential light chain-1 and motor domain of the myosin head during the ATPase cycle.0

Citation

Dessen P

MYL1 (myosin light chain 1)

Atlas Genet Cytogenet Oncol Haematol. 2008-07-01

Online version: http://atlasgeneticsoncology.org/gene/50200/myl1