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MYL9 (myosin light chain 9)

Identity

Alias_namesmyosin, light polypeptide 9, regulatory
myosin, light chain 9, regulatory
Alias_symbol (synonym)MYRL2
MLC2
LC20
MRLC1
Other aliasMLC-2C
HGNC (Hugo) MYL9
LocusID (NCBI) 10398
Atlas_Id 53856
Location 20q11.23  [Link to chromosome band 20q11]
Location_base_pair Starts at 36541519 and ends at 36551446 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ITCH (20q11.22) / MYL9 (20q11.23)ITGB1 (10p11.22) / MYL9 (20q11.23)ITCH 20q11.22 / MYL9 20q11.23

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  ITCH/MYL9 (20q11)

External links

Nomenclature
HGNC (Hugo)MYL9   15754
Cards
Entrez_Gene (NCBI)MYL9  10398  myosin light chain 9
AliasesLC20; MLC-2C; MLC2; MRLC1; 
MYRL2
GeneCards (Weizmann)MYL9
Ensembl hg19 (Hinxton)ENSG00000101335 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000101335 [Gene_View]  ENSG00000101335 [Sequence]  chr20:36541519-36551446 [Contig_View]  MYL9 [Vega]
ICGC DataPortalENSG00000101335
TCGA cBioPortalMYL9
AceView (NCBI)MYL9
Genatlas (Paris)MYL9
WikiGenes10398
SOURCE (Princeton)MYL9
Genetics Home Reference (NIH)MYL9
Genomic and cartography
GoldenPath hg38 (UCSC)MYL9  -     chr20:36541519-36551446 +  20q11.23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MYL9  -     20q11.23   [Description]    (hg19-Feb_2009)
GoldenPathMYL9 - 20q11.23 [CytoView hg19]  MYL9 - 20q11.23 [CytoView hg38]
ImmunoBaseENSG00000101335
Mapping of homologs : NCBIMYL9 [Mapview hg19]  MYL9 [Mapview hg38]
OMIM609905   
Gene and transcription
Genbank (Entrez)AF176042 AF176043 AK097235 AK130879 AL697699
RefSeq transcript (Entrez)NM_006097 NM_181526
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MYL9
Alternative Splicing GalleryENSG00000101335
Gene ExpressionMYL9 [ NCBI-GEO ]   MYL9 [ EBI - ARRAY_EXPRESS ]   MYL9 [ SEEK ]   MYL9 [ MEM ]
Gene Expression Viewer (FireBrowse)MYL9 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10398
GTEX Portal (Tissue expression)MYL9
Human Protein AtlasENSG00000101335-MYL9 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP24844   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP24844  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP24844
Splice isoforms : SwissVarP24844
PhosPhoSitePlusP24844
Domaine pattern : Prosite (Expaxy)EF_HAND_1 (PS00018)    EF_HAND_2 (PS50222)   
Domains : Interpro (EBI)EF-hand-dom_pair    EF_Hand_1_Ca_BS    EF_hand_dom   
Domain families : Pfam (Sanger)EF-hand_6 (PF13405)   
Domain families : Pfam (NCBI)pfam13405   
Domain families : Smart (EMBL)EFh (SM00054)  
Conserved Domain (NCBI)MYL9
DMDM Disease mutations10398
Blocks (Seattle)MYL9
SuperfamilyP24844
Human Protein Atlas [tissue]ENSG00000101335-MYL9 [tissue]
Peptide AtlasP24844
HPRD17619
IPIIPI00220278   IPI00030929   
Protein Interaction databases
DIP (DOE-UCLA)P24844
IntAct (EBI)P24844
FunCoupENSG00000101335
BioGRIDMYL9
STRING (EMBL)MYL9
ZODIACMYL9
Ontologies - Pathways
QuickGOP24844
Ontology : AmiGOstress fiber  calcium ion binding  cytosol  muscle myosin complex  muscle contraction  regulation of muscle contraction  structural constituent of muscle  Z disc  myosin heavy chain binding  regulation of megakaryocyte differentiation  platelet aggregation  
Ontology : EGO-EBIstress fiber  calcium ion binding  cytosol  muscle myosin complex  muscle contraction  regulation of muscle contraction  structural constituent of muscle  Z disc  myosin heavy chain binding  regulation of megakaryocyte differentiation  platelet aggregation  
Pathways : KEGGVascular smooth muscle contraction    Focal adhesion    Tight junction    Leukocyte transendothelial migration    Regulation of actin cytoskeleton   
NDEx NetworkMYL9
Atlas of Cancer Signalling NetworkMYL9
Wikipedia pathwaysMYL9
Orthology - Evolution
OrthoDB10398
GeneTree (enSembl)ENSG00000101335
Phylogenetic Trees/Animal Genes : TreeFamMYL9
HOGENOMP24844
Homologs : HomoloGeneMYL9
Homology/Alignments : Family Browser (UCSC)MYL9
Gene fusions - Rearrangements
Fusion : MitelmanITCH/MYL9 [20q11.22/20q11.23]  [t(20;20)(q11;q11)]  
Fusion PortalITCH 20q11.22 MYL9 20q11.23 LUAD
Fusion : QuiverMYL9
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMYL9 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MYL9
dbVarMYL9
ClinVarMYL9
1000_GenomesMYL9 
Exome Variant ServerMYL9
ExAC (Exome Aggregation Consortium)ENSG00000101335
GNOMAD BrowserENSG00000101335
Varsome BrowserMYL9
Genetic variants : HAPMAP10398
Genomic Variants (DGV)MYL9 [DGVbeta]
DECIPHERMYL9 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMYL9 
Mutations
ICGC Data PortalMYL9 
TCGA Data PortalMYL9 
Broad Tumor PortalMYL9
OASIS PortalMYL9 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMYL9  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMYL9
Mutations and Diseases : HGMDMYL9
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MYL9
DgiDB (Drug Gene Interaction Database)MYL9
DoCM (Curated mutations)MYL9 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MYL9 (select a term)
intoGenMYL9
Cancer3DMYL9(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609905   
Orphanet
DisGeNETMYL9
MedgenMYL9
Genetic Testing Registry MYL9
NextProtP24844 [Medical]
TSGene10398
GENETestsMYL9
Target ValidationMYL9
Huge Navigator MYL9 [HugePedia]
snp3D : Map Gene to Disease10398
BioCentury BCIQMYL9
ClinGenMYL9
Clinical trials, drugs, therapy
Protein Interactions : CTD10398
Pharm GKB GenePA31387
Clinical trialMYL9
Miscellaneous
canSAR (ICR)MYL9 (select the gene name)
HarmonizomeMYL9
DataMed IndexMYL9
Probes
Litterature
PubMed42 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMYL9
EVEXMYL9
GoPubMedMYL9
iHOPMYL9
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Jun 30 20:24:27 CEST 2020
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