MYO1E (myosin IE)

2018-02-01  

Identity

HGNC
MYO1E
LOCATION
15q22.2
LOCUSID
4643
ALIAS
FSGS6,HuncM-IC,MYO1C
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4643
MIM: 601479
HGNC: 7599
Ensembl: ENSG00000157483

Variants:

dbSNP: 4643
ClinVar: 4643
TCGA: ENSG00000157483
COSMIC: MYO1E

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000157483ENST00000288235Q12965
ENSG00000157483ENST00000288235Q4KMR3
ENSG00000157483ENST00000558571H0YN00
ENSG00000157483ENST00000559269H0YLJ4
ENSG00000157483ENST00000559412H0YNB0
ENSG00000157483ENST00000559489H0YLE5
ENSG00000157483ENST00000560749H0YNQ8

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
217560232011MYO1E mutations and childhood familial focal segmental glomerulosclerosis.102
172575982007Myosin 1E interacts with synaptojanin-1 and dynamin and is involved in endocytosis.71
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
208604082010Myo1e binds anionic phospholipids with high affinity.33
216978132011Exome sequencing identified MYO1E and NEIL1 as candidate genes for human autosomal recessive steroid-resistant nephrotic syndrome.30
119405822002The kinetic mechanism of Myo1e (human myosin-IC).25
257393412015Coinheritance of COL4A5 and MYO1E mutations accentuate the severity of kidney disease.13
275024872016ERK signaling promotes cell motility by inducing the localization of myosin 1E to lamellipodial tips.11
273298402016Myosin 1e promotes breast cancer malignancy by enhancing tumor cell proliferation and stimulating tumor cell de-differentiation.10
239773492013Myo1e impairment results in actin reorganization, podocyte dysfunction, and proteinuria in zebrafish and cultured podocytes.8

Citation

Dessen P

MYO1E (myosin IE)

Atlas Genet Cytogenet Oncol Haematol. 2018-02-01

Online version: http://atlasgeneticsoncology.org/gene/57299/myo1e