MYO9B (myosin IXB)

2013-06-01  

Identity

HGNC
MYO9B
LOCATION
19p13.11
LOCUSID
4650
ALIAS
CELIAC4,MYR5
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4650
MIM: 602129
HGNC: 7609
Ensembl: ENSG00000099331

Variants:

dbSNP: 4650
ClinVar: 4650
TCGA: ENSG00000099331
COSMIC: MYO9B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000099331ENST00000397274Q13459
ENSG00000099331ENST00000594824M0R0P8
ENSG00000099331ENST00000594971M0QZY4
ENSG00000099331ENST00000595618Q13459
ENSG00000099331ENST00000595641M0R300
ENSG00000099331ENST00000596942M0R332
ENSG00000099331ENST00000597073M0QXP0
ENSG00000099331ENST00000598419M0R240
ENSG00000099331ENST00000602158M0QXX1
ENSG00000099331ENST00000602177M0R2J3

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Fcgamma receptor (FCGR) dependent phagocytosisREACTOMER-HSA-2029480
Regulation of actin dynamics for phagocytic cup formationREACTOMER-HSA-2029482
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
162829762005Myosin IXB variant increases the risk of celiac disease and points toward a primary intestinal barrier defect.59
162829762005Myosin IXB variant increases the risk of celiac disease and points toward a primary intestinal barrier defect.59
170879402006Genetic variation in myosin IXB is associated with ulcerative colitis.30
170879402006Genetic variation in myosin IXB is associated with ulcerative colitis.30
118015972002Myosin-IXb is a single-headed and processive motor.24
225738892012A role for myosin IXb, a motor-RhoGAP chimera, in epithelial wound healing and tight junction regulation.18
265292572015Myo9b is a key player in SLIT/ROBO-mediated lung tumor suppression.13
156443182005BIG1 is a binding partner of myosin IXb and regulates its Rho-GTPase activating protein activity.12
192359132009Association between genetic variants in myosin IXB and Crohn's disease.12
179449962008The association of MYO9B gene in Italian patients with inflammatory bowel diseases.11

Citation

Dessen P

MYO9B (myosin IXB)

Atlas Genet Cytogenet Oncol Haematol. 2013-06-01

Online version: http://atlasgeneticsoncology.org/gene/53330/myo9b