MYRIP (myosin VIIA and Rab interacting protein)

2014-11-01  

Identity

HGNC
MYRIP
LOCATION
3p22.1
LOCUSID
25924
ALIAS
SLAC2-C,SLAC2C
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 25924
MIM: 611790
HGNC: 19156
Ensembl: ENSG00000170011

Variants:

dbSNP: 25924
ClinVar: 25924
TCGA: ENSG00000170011
COSMIC: MYRIP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170011ENST00000302541Q8NFW9
ENSG00000170011ENST00000396217Q8NFW9
ENSG00000170011ENST00000425621Q8NFW9
ENSG00000170011ENST00000444716Q8NFW9
ENSG00000170011ENST00000458292Q8NFW9
ENSG00000170011ENST00000458441F8WFC5
ENSG00000170011ENST00000539167Q8NFW9

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Peptide hormone metabolismREACTOMER-HSA-2980736
Insulin processingREACTOMER-HSA-264876

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
145173222003Involvement of the Rab27 binding protein Slac2c/MyRIP in insulin exocytosis.52
122210802002Slac2-c (synaptotagmin-like protein homologue lacking C2 domains-c), a novel linker protein that interacts with Rab27, myosin Va/VIIa, and actin.49
119643812002MyRIP, a novel Rab effector, enables myosin VIIa recruitment to retinal melanosomes.41
192702612009Rab27a and MyRIP regulate the amount and multimeric state of VWF released from endothelial cells.32
208618662010Genome-wide association identifies SKIV2L and MYRIP as protective factors for age-related macular degeneration.29
208618662010Genome-wide association identifies SKIV2L and MYRIP as protective factors for age-related macular degeneration.29
217404912011Myosin Va acts in concert with Rab27a and MyRIP to regulate acute von-Willebrand factor release from endothelial cells.25
184781592008Intramanchette transport during primate spermiogenesis: expression of dynein, myosin Va, motor recruiter myosin Va, VIIa-Rab27a/b interacting protein, and Rab27b in the manchette during human and monkey spermiogenesis.16
223964292012Myrip couples the capture of secretory granules by the actin-rich cell cortex and their attachment to the plasma membrane.13

Citation

Dessen P

MYRIP (myosin VIIA and Rab interacting protein)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/70641/myrip