NAA40 (N-alpha-acetyltransferase 40, NatD catalytic subunit)

2010-08-01  

Identity

HGNC
LOCATION
11q13.1
LOCUSID
ALIAS
NAT11,NatD,PATT1,hNatD
FUSION GENES

Other Information

Locus ID:

NCBI: 79829
HGNC: 25845
Ensembl: ENSG00000110583

Variants:

dbSNP: 79829
ClinVar: 79829
TCGA: ENSG00000110583
COSMIC: NAA40

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000110583ENST00000377793Q86UY6
ENSG00000110583ENST00000377793A0A024R5C6
ENSG00000110583ENST00000534965F5GY41
ENSG00000110583ENST00000539656F5H2C9
ENSG00000110583ENST00000542163Q86UY6
ENSG00000110583ENST00000544138F5GXF6

Expression (GTEx)

0
10
20
30
40
50
60

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
219354422011The human N-alpha-acetyltransferase 40 (hNaa40p/hNatD) is conserved from yeast and N-terminally acetylates histones H2A and H4.35
290305872017NatD promotes lung cancer progression by preventing histone H4 serine phosphorylation to activate Slug expression.18
196953382009Patt1, a novel protein acetyltransferase that is highly expressed in liver and downregulated in hepatocellular carcinoma, enhances apoptosis of hepatoma cells.17
266667502016Depletion of histone N-terminal-acetyltransferase Naa40 induces p53-independent apoptosis in colorectal cancer cells via the mitochondrial pathway.13
308583582019NAA40 contributes to colorectal cancer growth by controlling PRMT5 expression.6
242489122013Structure of Patt1 human proapoptotic histone acetyltransferase.1

Citation

Dessen P

NAA40 (N-alpha-acetyltransferase 40, NatD catalytic subunit)

Atlas Genet Cytogenet Oncol Haematol. 2010-08-01

Online version: http://atlasgeneticsoncology.org/gene/51594/naa40