Atlas of Genetics and Cytogenetics in Oncology and Haematology

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NAALADL2 (N-acetylated alpha-linked acidic dipeptidase like 2)

Identity

Other alias-
HGNC (Hugo) NAALADL2
LocusID (NCBI) 254827
Atlas_Id 55209
Location 3q26.31  [Link to chromosome band 3q26]
Location_base_pair Starts at 174859321 and ends at 175805640 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ATP13A4 (3q29) / NAALADL2 (3q26.31)CACNA2D1 (7q21.11) / NAALADL2 (3q26.31)FNDC3B (3q26.31) / NAALADL2 (3q26.31)
MBNL1 (3q25.1) / NAALADL2 (3q26.31)MECR (1p35.3) / NAALADL2 (3q26.31)NAALADL2 (3q26.31) / ABCC5 (3q27.1)
NAALADL2 (3q26.31) / CAMK2N1 (1p36.12)NAALADL2 (3q26.31) / CORO1C (12q24.11)NAALADL2 (3q26.31) / DRD3 (3q13.31)
NAALADL2 (3q26.31) / FBXO45 (3q29)NAALADL2 (3q26.31) / LYZ (12q15)NAALADL2 (3q26.31) / NCKAP5 (2q21.2)
NAALADL2 (3q26.31) / NLGN1 (3q26.31)NAALADL2 (3q26.31) / PEX5L (3q26.33)NAALADL2 (3q26.31) / SMC5 (9q21.12)
RBM28 (7q32.1) / NAALADL2 (3q26.31)SERPINI1 (3q26.1) / NAALADL2 (3q26.31)SLC22A23 (6p25.2) / NAALADL2 (3q26.31)
ATP13A4 3q29 / NAALADL2 3q26.31CACNA2D1 7q21.11 / NAALADL2 3q26.31FNDC3B 3q26.31 / NAALADL2 3q26.31
MBNL1 3q25.1 / NAALADL2 3q26.31MECR 1p35.3 / NAALADL2 3q26.31NAALADL2 3q26.31 / ABCC5 3q27.1
NAALADL2 3q26.31 / DRD3 3q13.31NAALADL2 3q26.31 / FBXO45 3q29NAALADL2 3q26.31 / NCKAP5 2q21.2
NAALADL2 3q26.31 / NLGN1 3q26.31NAALADL2 3q26.31 / PEX5L 3q26.33NAALADL2 3q26.31 / SMC5 9q21.12
SERPINI1 3q26.1 / NAALADL2 3q26.31SLC22A23 6p25.2 / NAALADL2 3q26.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 16 ]
  t(1;3)(p35;q26) MECR/NAALADL2
t(2;3)(q21;q26) NAALADL2/NCKAP5
t(3;3)(q13;q26) NAALADL2/DRD3
t(3;3)(q25;q26) MBNL1/NAALADL2
FNDC3B/NAALADL2 (3q26)
NAALADL2/NLGN1 (3q26)
NAALADL2/PEX5L (3q26)
NLGN1/NAALADL2 (3q26)
SERPINI1/NAALADL2 (3q26)
t(3;3)(q26;q27) NAALADL2/ABCC5
t(3;3)(q26;q27) NAALADL2/SENP2
t(3;3)(q26;q29) ATP13A4/NAALADL2
t(3;3)(q26;q29) NAALADL2/FBXO45
t(3;6)(q26;p25) SLC22A23/NAALADL2
t(3;7)(q26;q21) CACNA2D1/NAALADL2
t(3;9)(q26;q21) NAALADL2/SMC5

External links

Nomenclature
HGNC (Hugo)NAALADL2   23219
Cards
Entrez_Gene (NCBI)NAALADL2  254827  N-acetylated alpha-linked acidic dipeptidase like 2
Aliases
GeneCards (Weizmann)NAALADL2
Ensembl hg19 (Hinxton)ENSG00000177694 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000177694 [Gene_View]  ENSG00000177694 [Sequence]  chr3:174859321-175805640 [Contig_View]  NAALADL2 [Vega]
ICGC DataPortalENSG00000177694
TCGA cBioPortalNAALADL2
AceView (NCBI)NAALADL2
Genatlas (Paris)NAALADL2
WikiGenes254827
SOURCE (Princeton)NAALADL2
Genetics Home Reference (NIH)NAALADL2
Genomic and cartography
GoldenPath hg38 (UCSC)NAALADL2  -     chr3:174859321-175805640 +  3q26.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NAALADL2  -     3q26.31   [Description]    (hg19-Feb_2009)
GoldenPathNAALADL2 - 3q26.31 [CytoView hg19]  NAALADL2 - 3q26.31 [CytoView hg38]
ImmunoBaseENSG00000177694
Mapping of homologs : NCBINAALADL2 [Mapview hg19]  NAALADL2 [Mapview hg38]
OMIM608806   
Gene and transcription
Genbank (Entrez)AJ607396 AJ607397 AJ607398 AJ607399 AJ607400
RefSeq transcript (Entrez)NM_207015
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NAALADL2
Cluster EST : UnigeneHs.660010 [ NCBI ]
CGAP (NCI)Hs.660010
Alternative Splicing GalleryENSG00000177694
Gene ExpressionNAALADL2 [ NCBI-GEO ]   NAALADL2 [ EBI - ARRAY_EXPRESS ]   NAALADL2 [ SEEK ]   NAALADL2 [ MEM ]
Gene Expression Viewer (FireBrowse)NAALADL2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)254827
GTEX Portal (Tissue expression)NAALADL2
Human Protein AtlasENSG00000177694-NAALADL2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ58DX5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ58DX5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ58DX5
Splice isoforms : SwissVarQ58DX5
PhosPhoSitePlusQ58DX5
Domains : Interpro (EBI)Peptidase_M28    TFR-like_dimer_dom_sf   
Domain families : Pfam (Sanger)Peptidase_M28 (PF04389)   
Domain families : Pfam (NCBI)pfam04389   
Conserved Domain (NCBI)NAALADL2
DMDM Disease mutations254827
Blocks (Seattle)NAALADL2
SuperfamilyQ58DX5
Human Protein Atlas [tissue]ENSG00000177694-NAALADL2 [tissue]
Peptide AtlasQ58DX5
HPRD16388
IPIIPI00477389   IPI00434770   IPI00816307   IPI00924728   
Protein Interaction databases
DIP (DOE-UCLA)Q58DX5
IntAct (EBI)Q58DX5
FunCoupENSG00000177694
BioGRIDNAALADL2
STRING (EMBL)NAALADL2
ZODIACNAALADL2
Ontologies - Pathways
QuickGOQ58DX5
Ontology : AmiGOprotein binding  nucleoplasm  response to bacterium  integral component of membrane  
Ontology : EGO-EBIprotein binding  nucleoplasm  response to bacterium  integral component of membrane  
NDEx NetworkNAALADL2
Atlas of Cancer Signalling NetworkNAALADL2
Wikipedia pathwaysNAALADL2
Orthology - Evolution
OrthoDB254827
GeneTree (enSembl)ENSG00000177694
Phylogenetic Trees/Animal Genes : TreeFamNAALADL2
HOGENOMQ58DX5
Homologs : HomoloGeneNAALADL2
Homology/Alignments : Family Browser (UCSC)NAALADL2
Gene fusions - Rearrangements
Fusion : MitelmanATP13A4/NAALADL2 [3q29/3q26.31]  [t(3;3)(q26;q29)]  
Fusion : MitelmanCACNA2D1/NAALADL2 [7q21.11/3q26.31]  [t(3;7)(q26;q21)]  
Fusion : MitelmanFNDC3B/NAALADL2 [3q26.31/3q26.31]  [t(3;3)(q26;q26)]  
Fusion : MitelmanMBNL1/NAALADL2 [3q25.1/3q26.31]  [t(3;3)(q25;q26)]  
Fusion : MitelmanMECR/NAALADL2 [1p35.3/3q26.31]  [t(1;3)(p35;q26)]  
Fusion : MitelmanNAALADL2/ABCC5 [3q26.31/3q27.1]  [t(3;3)(q26;q27)]  
Fusion : MitelmanNAALADL2/DRD3 [3q26.31/3q13.31]  [t(3;3)(q13;q26)]  
Fusion : MitelmanNAALADL2/FBXO45 [3q26.31/3q29]  [t(3;3)(q26;q29)]  
Fusion : MitelmanNAALADL2/NCKAP5 [3q26.31/2q21.2]  [t(2;3)(q21;q26)]  
Fusion : MitelmanNAALADL2/NLGN1 [3q26.31/3q26.31]  [t(3;3)(q26;q26)]  
Fusion : MitelmanNAALADL2/PEX5L [3q26.31/3q26.33]  [t(3;3)(q26;q26)]  
Fusion : MitelmanNAALADL2/SMC5 [3q26.31/9q21.12]  [t(3;9)(q26;q21)]  
Fusion : MitelmanSERPINI1/NAALADL2 [3q26.1/3q26.31]  [t(3;3)(q26;q26)]  
Fusion : MitelmanSLC22A23/NAALADL2 [6p25.2/3q26.31]  [t(3;6)(q26;p25)]  
Fusion PortalATP13A4 3q29 NAALADL2 3q26.31 LUSC
Fusion PortalCACNA2D1 7q21.11 NAALADL2 3q26.31 HNSC
Fusion PortalFNDC3B 3q26.31 NAALADL2 3q26.31 LUSC
Fusion PortalMBNL1 3q25.1 NAALADL2 3q26.31 BRCA
Fusion PortalMECR 1p35.3 NAALADL2 3q26.31 BRCA
Fusion PortalNAALADL2 3q26.31 ABCC5 3q27.1 LUSC
Fusion PortalNAALADL2 3q26.31 DRD3 3q13.31 HNSC
Fusion PortalNAALADL2 3q26.31 FBXO45 3q29 BRCA
Fusion PortalNAALADL2 3q26.31 NCKAP5 2q21.2 LUSC
Fusion PortalNAALADL2 3q26.31 NLGN1 3q26.31 BRCA
Fusion PortalNAALADL2 3q26.31 PEX5L 3q26.33 BRCA
Fusion PortalNAALADL2 3q26.31 SMC5 9q21.12 LUSC
Fusion PortalSERPINI1 3q26.1 NAALADL2 3q26.31 BRCA
Fusion PortalSLC22A23 6p25.2 NAALADL2 3q26.31 BRCA
Fusion : QuiverNAALADL2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNAALADL2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NAALADL2
dbVarNAALADL2
ClinVarNAALADL2
1000_GenomesNAALADL2 
Exome Variant ServerNAALADL2
ExAC (Exome Aggregation Consortium)ENSG00000177694
GNOMAD BrowserENSG00000177694
Varsome BrowserNAALADL2
Genetic variants : HAPMAP254827
Genomic Variants (DGV)NAALADL2 [DGVbeta]
DECIPHERNAALADL2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNAALADL2 
Mutations
ICGC Data PortalNAALADL2 
TCGA Data PortalNAALADL2 
Broad Tumor PortalNAALADL2
OASIS PortalNAALADL2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNAALADL2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNAALADL2
Mutations and Diseases : HGMDNAALADL2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NAALADL2
DgiDB (Drug Gene Interaction Database)NAALADL2
DoCM (Curated mutations)NAALADL2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NAALADL2 (select a term)
intoGenNAALADL2
Cancer3DNAALADL2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608806   
Orphanet
DisGeNETNAALADL2
MedgenNAALADL2
Genetic Testing Registry NAALADL2
NextProtQ58DX5 [Medical]
TSGene254827
GENETestsNAALADL2
Target ValidationNAALADL2
Huge Navigator NAALADL2 [HugePedia]
snp3D : Map Gene to Disease254827
BioCentury BCIQNAALADL2
ClinGenNAALADL2 (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD254827
Chemical/Pharm GKB GenePA142671295
Clinical trialNAALADL2
Miscellaneous
canSAR (ICR)NAALADL2 (select the gene name)
DataMed IndexNAALADL2
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNAALADL2
EVEXNAALADL2
GoPubMedNAALADL2
iHOPNAALADL2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Nov 13 17:57:07 CET 2019
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