NABP2 (nucleic acid binding protein 2)

2008-08-01  

Identity

HGNC
NABP2
LOCATION
12q13.3
LOCUSID
79035
ALIAS
OBFC2B,SOSS-B1,SSB1,hSSB1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 79035
MIM: 612104
HGNC: 28412
Ensembl: ENSG00000139579

Variants:

dbSNP: 79035
ClinVar: 79035
TCGA: ENSG00000139579
COSMIC: NABP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000139579ENST00000267023Q9BQ15
ENSG00000139579ENST00000267023A0A024RB89
ENSG00000139579ENST00000341463Q9BQ15
ENSG00000139579ENST00000341463A0A024RB89
ENSG00000139579ENST00000380198Q9BQ15
ENSG00000139579ENST00000380198A0A024RB89
ENSG00000139579ENST00000399713C9JMP5
ENSG00000139579ENST00000447747C9JT95

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
RNA polymerase II transcribes snRNA genesREACTOMER-HSA-6807505

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
184491952008Single-stranded DNA-binding protein hSSB1 is critical for genomic stability.94
196053512009HSSB1 and hSSB2 form similar multiprotein complexes that participate in DNA damage response.48
231785942013The SOSS1 single-stranded DNA binding complex promotes DNA end resection in concert with Exo1.43
197865742009INTS3 controls the hSSB1-mediated DNA damage response.41
247534082014Human single-stranded DNA binding protein 1 (hSSB1/NABP2) is required for the stability and repair of stalled replication forks.20
262612122015hSSB1 (NABP2/ OBFC2B) is required for the repair of 8-oxo-guanine by the hOGG1-mediated base excision repair pathway.11
273872852016A structural analysis of DNA binding by hSSB1 (NABP2/OBFC2B) in solution.8
272732182016hSSB1 (NABP2/OBFC2B) is regulated by oxidative stress.7
241048802013Identification of two novel BRCA1-partner genes in the DNA double-strand break repair pathway.2
285062942017hSSB1 associates with and promotes stability of the BLM helicase.1

Citation

Dessen P

NABP2 (nucleic acid binding protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2008-08-01

Online version: http://atlasgeneticsoncology.org/gene/50299/nabp2