NAPEPLD (N-acyl phosphatidylethanolamine phospholipase D)

2014-11-01  

Identity

HGNC
NAPEPLD
LOCATION
7q22.1
LOCUSID
222236
ALIAS
C7orf18,FMP30,NAPE-PLD
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 222236
MIM: 612334
HGNC: 21683
Ensembl: ENSG00000161048

Variants:

dbSNP: 222236
ClinVar: 222236
TCGA: ENSG00000161048
COSMIC: NAPEPLD

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000161048ENST00000341533Q6IQ20
ENSG00000161048ENST00000417955Q6IQ20
ENSG00000161048ENST00000418294C9JGB1
ENSG00000161048ENST00000420631H0Y4Y2
ENSG00000161048ENST00000422589Q6IQ20
ENSG00000161048ENST00000427257Q6IQ20
ENSG00000161048ENST00000465647Q6IQ20

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Retrograde endocannabinoid signalingKEGGhsa04723
Retrograde endocannabinoid signalingKEGGko04723
DiseaseREACTOMER-HSA-1643685
Diseases of signal transductionREACTOMER-HSA-5663202
Diseases associated with visual transductionREACTOMER-HSA-2474795
Retinoid cycle disease eventsREACTOMER-HSA-2453864
Biosynthesis of A2E, implicated in retinal degradationREACTOMER-HSA-2466712
Signal TransductionREACTOMER-HSA-162582
Visual phototransductionREACTOMER-HSA-2187338
The canonical retinoid cycle in rods (twilight vision)REACTOMER-HSA-2453902

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
228279152012Developmental trajectory of the endocannabinoid system in human dorsolateral prefrontal cortex.27
256845742015Structure of human N-acylphosphatidylethanolamine-hydrolyzing phospholipase D: regulation of fatty acid ethanolamide biosynthesis by bile acids.23
203693622010Histomorphometric evaluation of cannabinoid receptor and anandamide modulating enzyme expression in the human endometrium through the menstrual cycle.22
212511152011Cannabinoid receptor and N-acyl phosphatidylethanolamine phospholipase D--evidence for altered expression in multiple sclerosis.12
240184232013Isolevuglandin-modified phosphatidylethanolamine is metabolized by NAPE-hydrolyzing phospholipase D.9
231226992013Differential expression of endocannabinoid system in normal and preeclamptic placentas: effects on nitric oxide synthesis.8
208853902011A common haplotype in NAPEPLD is associated with severe obesity in a Norwegian population-based cohort (the HUNT study).5
208853902011A common haplotype in NAPEPLD is associated with severe obesity in a Norwegian population-based cohort (the HUNT study).5
197156852009Effect of synthetic and natural phospholipids on N-acylphosphatidylethanolamine-hydrolyzing phospholipase D activity.2
241261892013No association of endocannabinoid genes with bipolar disorder or lithium response in a Sardinian sample.2

Citation

Dessen P

NAPEPLD (N-acyl phosphatidylethanolamine phospholipase D)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/70690/napepld