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NARS1 (asparaginyl-tRNA synthetase 1)

Identity

Alias_namesNARS
asparaginyl-tRNA synthetase
Other aliasASNRS
HGNC (Hugo) NARS1
LocusID (NCBI) 4677
Atlas_Id 56997
Location 18q21.31  [Link to chromosome band 18q21]
Location_base_pair Starts at 57600661 and ends at 57621945 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute


External links

Nomenclature
HGNC (Hugo)NARS1   7643
Cards
Entrez_Gene (NCBI)NARS1  4677  asparaginyl-tRNA synthetase 1
AliasesASNRS; NARS
GeneCards (Weizmann)NARS1
Ensembl hg19 (Hinxton)ENSG00000134440 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000134440 [Gene_View]  ENSG00000134440 [Sequence]  chr18:57600661-57621945 [Contig_View]  NARS1 [Vega]
ICGC DataPortalENSG00000134440
TCGA cBioPortalNARS1
AceView (NCBI)NARS1
Genatlas (Paris)NARS1
WikiGenes4677
SOURCE (Princeton)NARS1
Genetics Home Reference (NIH)NARS1
Genomic and cartography
GoldenPath hg38 (UCSC)NARS1  -     chr18:57600661-57621945 -  -   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NARS1  -     -   [Description]    (hg19-Feb_2009)
GoldenPathNARS1 - - [CytoView hg19]  NARS1 - - [CytoView hg38]
ImmunoBaseENSG00000134440
Mapping of homologs : NCBINARS1 [Mapview hg19]  NARS1 [Mapview hg38]
OMIM108410   
Gene and transcription
Genbank (Entrez)AJ000334 AK129897 AK222835 AK293985 AK294364
RefSeq transcript (Entrez)NM_004539
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NARS1
Cluster EST : UnigeneHs.465224 [ NCBI ]
CGAP (NCI)Hs.465224
Alternative Splicing GalleryENSG00000134440
Gene ExpressionNARS1 [ NCBI-GEO ]   NARS1 [ EBI - ARRAY_EXPRESS ]   NARS1 [ SEEK ]   NARS1 [ MEM ]
Gene Expression Viewer (FireBrowse)NARS1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4677
GTEX Portal (Tissue expression)NARS1
Human Protein AtlasENSG00000134440-NARS1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43776   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43776  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43776
Splice isoforms : SwissVarO43776
Catalytic activity : Enzyme6.1.1.22 [ Enzyme-Expasy ]   6.1.1.226.1.1.22 [ IntEnz-EBI ]   6.1.1.22 [ BRENDA ]   6.1.1.22 [ KEGG ]   
PhosPhoSitePlusO43776
Domaine pattern : Prosite (Expaxy)AA_TRNA_LIGASE_II (PS50862)   
Domains : Interpro (EBI)aa-tRNA-synt_II    aa-tRNA-synth_II    Asn-tRNA-ligase    Asp/Asn-tRNA-synth_IIb    NA-bd_OB-fold    NA-bd_OB_tRNA   
Domain families : Pfam (Sanger)tRNA-synt_2 (PF00152)    tRNA_anti-codon (PF01336)   
Domain families : Pfam (NCBI)pfam00152    pfam01336   
Conserved Domain (NCBI)NARS1
DMDM Disease mutations4677
Blocks (Seattle)NARS1
PDB (RSDB)4ZYA   
PDB Europe4ZYA   
PDB (PDBSum)4ZYA   
PDB (IMB)4ZYA   
Structural Biology KnowledgeBase4ZYA   
SCOP (Structural Classification of Proteins)4ZYA   
CATH (Classification of proteins structures)4ZYA   
SuperfamilyO43776
Human Protein Atlas [tissue]ENSG00000134440-NARS1 [tissue]
Peptide AtlasO43776
IPIIPI00306960   IPI00646656   IPI00643900   IPI00647678   
Protein Interaction databases
DIP (DOE-UCLA)O43776
IntAct (EBI)O43776
FunCoupENSG00000134440
BioGRIDNARS1
STRING (EMBL)NARS1
ZODIACNARS1
Ontologies - Pathways
QuickGOO43776
Ontology : AmiGOnucleic acid binding  asparagine-tRNA ligase activity  ATP binding  cytoplasm  cytosol  cytosol  tRNA aminoacylation for protein translation  asparaginyl-tRNA aminoacylation  extracellular exosome  
Ontology : EGO-EBInucleic acid binding  asparagine-tRNA ligase activity  ATP binding  cytoplasm  cytosol  cytosol  tRNA aminoacylation for protein translation  asparaginyl-tRNA aminoacylation  extracellular exosome  
NDEx NetworkNARS1
Atlas of Cancer Signalling NetworkNARS1
Wikipedia pathwaysNARS1
Orthology - Evolution
OrthoDB4677
GeneTree (enSembl)ENSG00000134440
Phylogenetic Trees/Animal Genes : TreeFamNARS1
HOGENOMO43776
Homologs : HomoloGeneNARS1
Homology/Alignments : Family Browser (UCSC)NARS1
Gene fusions - Rearrangements
Fusion : QuiverNARS1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNARS1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NARS1
dbVarNARS1
ClinVarNARS1
1000_GenomesNARS1 
Exome Variant ServerNARS1
ExAC (Exome Aggregation Consortium)ENSG00000134440
GNOMAD BrowserENSG00000134440
Varsome BrowserNARS1
Genetic variants : HAPMAP4677
Genomic Variants (DGV)NARS1 [DGVbeta]
DECIPHERNARS1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNARS1 
Mutations
ICGC Data PortalNARS1 
TCGA Data PortalNARS1 
Broad Tumor PortalNARS1
OASIS PortalNARS1 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDNARS1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NARS1
DgiDB (Drug Gene Interaction Database)NARS1
DoCM (Curated mutations)NARS1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NARS1 (select a term)
intoGenNARS1
Cancer3DNARS1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM108410   
Orphanet
DisGeNETNARS1
MedgenNARS1
Genetic Testing Registry NARS1
NextProtO43776 [Medical]
TSGene4677
GENETestsNARS1
Target ValidationNARS1
Huge Navigator NARS1 [HugePedia]
snp3D : Map Gene to Disease4677
BioCentury BCIQNARS1
ClinGenNARS1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4677
Chemical/Pharm GKB GenePA31447
Clinical trialNARS1
Miscellaneous
canSAR (ICR)NARS1 (select the gene name)
DataMed IndexNARS1
Probes
Litterature
PubMed46 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNARS1
EVEXNARS1
GoPubMedNARS1
iHOPNARS1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Nov 13 17:57:14 CET 2019

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