NBL1 (NBL1, DAN family BMP antagonist)

2003-02-01 Affiliation

Identity

HGNC

NBL1

LOCATION

1p36.13

LOCUSID

4681

ALIAS

D1S1733E,DAN,DAND1,NB,NO3

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 4681
MIM: 600613
HGNC: 7650
Ensembl: ENSG00000158747

Variants:

dbSNP: 4681
ClinVar: 4681
TCGA: ENSG00000158747
COSMIC: NBL1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000158747	ENST00000289749	P41271
ENSG00000158747	ENST00000375136	P41271
ENSG00000158747	ENST00000425400	A3KFI3
ENSG00000158747	ENST00000427894	E5RFZ1
ENSG00000158747	ENST00000428975	A3KFI4
ENSG00000158747	ENST00000439278	A3KFI1
ENSG00000158747	ENST00000439664	A3KFI2
ENSG00000158747	ENST00000451758	A3KFI5
ENSG00000158747	ENST00000548815	P41271
ENSG00000158747	ENST00000602662	P41271
ENSG00000158747	ENST00000615215	A0A087WTY6
ENSG00000158747	ENST00000618761	P41271
ENSG00000158747	ENST00000621723	P41271
ENSG00000158747	ENST00000622566	P41271

Expression (GTEx)

100

200

300

400

500

600

700

800

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
TGF-beta signaling pathway	KEGG	ko04350
TGF-beta signaling pathway	KEGG	hsa04350

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
15528323	2004	Cutting edge: bone morphogenetic protein antagonists Drm/Gremlin and Dan interact with Slits and act as negative regulators of monocyte chemotaxis.	23
24810382	2014	The DAN family: modulators of TGF-β signaling and beyond.	23
19995712	2009	NBL1 and anillin (ANLN) genes over-expression in pancreatic carcinoma.	18
25561725	2015	Structure of neuroblastoma suppressor of tumorigenicity 1 (NBL1): insights for the functional variability across bone morphogenetic protein (BMP) antagonists.	9
27524626	2016	Structure of Gremlin-2 in Complex with GDF5 Gives Insight into DAN-Family-Mediated BMP Antagonism.	9
21743959	2011	Analysis of laser-microdissected prostate cancer tissues reveals potential tumor markers.	8
22948749	2013	The search for secreted proteins in prostate cancer by the Escherichia coli ampicillin secretion trap: expression of NBL1 is highly restricted to the prostate and is related to cancer progression.	3
12150978	2002	p73-dependent expression of DAN during cisplatin-induced cell death and osteoblast differentiation.	0

Citation

Dessen P

NBL1 (NBL1, DAN family BMP antagonist)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41501/nbl1