NCK1 (NCK adaptor protein 1)

2003-02-01  

Identity

HGNC
LOCATION
3q22.3
LOCUSID
ALIAS
NCK,NCKalpha,nck-1
FUSION GENES

Other Information

Locus ID:

NCBI: 4690
MIM: 600508
HGNC: 7664
Ensembl: ENSG00000158092

Variants:

dbSNP: 4690
ClinVar: 4690
TCGA: ENSG00000158092
COSMIC: NCK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000158092ENST00000288986P16333
ENSG00000158092ENST00000288986A0A0S2Z4Y3
ENSG00000158092ENST00000467911C9JAB9
ENSG00000158092ENST00000469404P16333
ENSG00000158092ENST00000476286C9J0K5
ENSG00000158092ENST00000481752P16333
ENSG00000158092ENST00000481752A0A0S2Z4Y3
ENSG00000158092ENST00000485096C9K098
ENSG00000158092ENST00000488930C9J869
ENSG00000158092ENST00000491539C9JVV5
ENSG00000158092ENST00000496489H7C5C7

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
ErbB signaling pathwayKEGGko04012
Axon guidanceKEGGko04360
T cell receptor signaling pathwayKEGGko04660
Pathogenic Escherichia coli infectionKEGGko05130
ErbB signaling pathwayKEGGhsa04012
Axon guidanceKEGGhsa04360
T cell receptor signaling pathwayKEGGhsa04660
Pathogenic Escherichia coli infectionKEGGhsa05130
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
TCR signalingREACTOMER-HSA-202403
Generation of second messenger moleculesREACTOMER-HSA-202433
Signaling by the B Cell Receptor (BCR)REACTOMER-HSA-983705
Antigen activates B Cell Receptor (BCR) leading to generation of second messengersREACTOMER-HSA-983695
Innate Immune SystemREACTOMER-HSA-168249
Fcgamma receptor (FCGR) dependent phagocytosisREACTOMER-HSA-2029480
Regulation of actin dynamics for phagocytic cup formationREACTOMER-HSA-2029482
Signal TransductionREACTOMER-HSA-162582
Signaling by PDGFREACTOMER-HSA-186797
Downstream signal transductionREACTOMER-HSA-186763
Signaling by VEGFREACTOMER-HSA-194138
VEGFA-VEGFR2 PathwayREACTOMER-HSA-4420097
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate WASPs and WAVEsREACTOMER-HSA-5663213
Cell-Cell communicationREACTOMER-HSA-1500931
Nephrin interactionsREACTOMER-HSA-373753
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Netrin-1 signalingREACTOMER-HSA-373752
DCC mediated attractive signalingREACTOMER-HSA-418885
Signaling by Robo receptorREACTOMER-HSA-376176
Activation of RacREACTOMER-HSA-428540

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
121815702002Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck.276
165439522006Nephrin ectodomain engagement results in Src kinase activation, nephrin phosphorylation, Nck recruitment, and actin polymerization.136
253213922014Phase transitions of multivalent proteins can promote clustering of membrane receptors.95
178039072007Septins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7.75
205628272010Cooperative interactions at the SLP-76 complex are critical for actin polymerization.56
120074182002Grb2 and Nck act cooperatively to promote actin-based motility of vaccinia virus.54
147577532004Clustering of Nck by a 12-residue Tir phosphopeptide is sufficient to trigger localized actin assembly.50
166360662006The phosphotyrosine peptide binding specificity of Nck1 and Nck2 Src homology 2 domains.40
182120582008Phosphorylated YDXV motifs and Nck SH2/SH3 adaptors act cooperatively to induce actin reorganization.37
226138342012Stoichiometry of Nck-dependent actin polymerization in living cells.28

Citation

Dessen P

NCK1 (NCK adaptor protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41505/nck1