NCK2 (NCK adaptor protein 2)

2012-02-01  

Identity

HGNC
LOCATION
2q12.2
LOCUSID
ALIAS
GRB4,NCKbeta
FUSION GENES

Other Information

Locus ID:

NCBI: 8440
MIM: 604930
HGNC: 7665
Ensembl: ENSG00000071051

Variants:

dbSNP: 8440
ClinVar: 8440
TCGA: ENSG00000071051
COSMIC: NCK2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000071051ENST00000233154O43639
ENSG00000071051ENST00000233154A0A0S2Z4M6
ENSG00000071051ENST00000393348E7EPF5
ENSG00000071051ENST00000393349O43639
ENSG00000071051ENST00000393349A0A0S2Z4M6
ENSG00000071051ENST00000425756E9PEE2
ENSG00000071051ENST00000451463E7ERP6
ENSG00000071051ENST00000522586E7ERP6

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
ErbB signaling pathwayKEGGko04012
Axon guidanceKEGGko04360
T cell receptor signaling pathwayKEGGko04660
Pathogenic Escherichia coli infectionKEGGko05130
ErbB signaling pathwayKEGGhsa04012
Axon guidanceKEGGhsa04360
T cell receptor signaling pathwayKEGGhsa04660
Pathogenic Escherichia coli infectionKEGGhsa05130
Signal TransductionREACTOMER-HSA-162582
Signaling by PDGFREACTOMER-HSA-186797
Downstream signal transductionREACTOMER-HSA-186763
Signaling by VEGFREACTOMER-HSA-194138
VEGFA-VEGFR2 PathwayREACTOMER-HSA-4420097
Cell-Cell communicationREACTOMER-HSA-1500931
Nephrin interactionsREACTOMER-HSA-373753
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Signaling by Robo receptorREACTOMER-HSA-376176
Activation of RacREACTOMER-HSA-428540
EPH-Ephrin signalingREACTOMER-HSA-2682334
Ephrin signalingREACTOMER-HSA-3928664

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
121101862002Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation.128
178039072007Septins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7.75
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
166360662006The phosphotyrosine peptide binding specificity of Nck1 and Nck2 Src homology 2 domains.40
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
168352422006Nck in a complex containing the catalytic subunit of protein phosphatase 1 regulates eukaryotic initiation factor 2alpha signaling and cell survival to endoplasmic reticulum stress.19
185552702008Structural and functional evidence that Nck interaction with CD3epsilon regulates T-cell receptor activity.16
242875952013Proteasomal degradation of Nck1 but not Nck2 regulates RhoA activation and actin dynamics.14
167529082006Structural insight into the binding diversity between the human Nck2 SH3 domains and proline-rich proteins.13
157646012005Structural insight into the binding diversity between the Tyr-phosphorylated human ephrinBs and Nck2 SH2 domain.11

Citation

Dessen P

NCK2 (NCK adaptor protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2012-02-01

Online version: http://atlasgeneticsoncology.org/gene/52582/nck2