| Nomenclature |
|---|
| HGNC (Hugo) | NCKAP1L 4862 |
| Cards |
|---|
| Entrez_Gene (NCBI) | NCKAP1L 3071 NCK associated protein 1 like |
| Aliases | HEM1 |
| GeneCards (Weizmann) | NCKAP1L |
| Ensembl hg19 (Hinxton) | ENSG00000123338 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000123338 [Gene_View] ENSG00000123338 [Sequence] chr12:54497752-54548243 [Contig_View] NCKAP1L [Vega] |
| ICGC DataPortal | ENSG00000123338 |
| TCGA cBioPortal | NCKAP1L |
| AceView (NCBI) | NCKAP1L |
| Genatlas (Paris) | NCKAP1L |
| WikiGenes | 3071 |
| SOURCE (Princeton) | NCKAP1L |
| Genetics Home Reference (NIH) | NCKAP1L |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | NCKAP1L - chr12:54497752-54548243 + 12q13.13 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | NCKAP1L - 12q13.13 [Description] (hg19-Feb_2009) |
| GoldenPath | NCKAP1L - 12q13.13 [CytoView hg19] NCKAP1L - 12q13.13 [CytoView hg38] |
| ImmunoBase | ENSG00000123338 |
| Mapping of homologs : NCBI | NCKAP1L [Mapview hg19] NCKAP1L [Mapview hg38] |
| OMIM | 141180 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AI924363 AK300783 AK314012 AU100069 AW575485 |
| RefSeq transcript (Entrez) | NM_001184976 NM_005337 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | NCKAP1L |
| Alternative Splicing Gallery | ENSG00000123338 |
| Gene Expression | NCKAP1L [ NCBI-GEO ] NCKAP1L [ EBI - ARRAY_EXPRESS ]
NCKAP1L [ SEEK ] NCKAP1L [ MEM ] |
| Gene Expression Viewer (FireBrowse) | NCKAP1L [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevestigator | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 3071 |
| GTEX Portal (Tissue expression) | NCKAP1L |
| Human Protein Atlas | ENSG00000123338-NCKAP1L [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | P55160 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | P55160 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | P55160 |
| Splice isoforms : SwissVar | P55160 |
| PhosPhoSitePlus | P55160 |
| Domains : Interpro (EBI) | Nck-associated_protein-1 |
| Domain families : Pfam (Sanger) | Nckap1 (PF09735) |
| Domain families : Pfam (NCBI) | pfam09735 |
| Conserved Domain (NCBI) | NCKAP1L |
| DMDM Disease mutations | 3071 |
| Blocks (Seattle) | NCKAP1L |
| Superfamily | P55160 |
| Human Protein Atlas [tissue] | ENSG00000123338-NCKAP1L [tissue] |
| Peptide Atlas | P55160 |
| HPRD | 00781 |
| IPI | IPI00023407 IPI01022786 IPI01021337 IPI00793989 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | P55160 |
| IntAct (EBI) | P55160 |
| FunCoup | ENSG00000123338 |
| BioGRID | NCKAP1L |
| STRING (EMBL) | NCKAP1L |
| ZODIAC | NCKAP1L |
| Ontologies - Pathways |
|---|
| QuickGO | P55160 |
| Ontology : AmiGO | cell morphogenesis B cell homeostasis myeloid cell homeostasis GTPase activator activity protein binding cytosol cytosol plasma membrane integral component of plasma membrane chemotaxis membrane cell migration maintenance of cell polarity cell projection assembly protein kinase activator activity neutrophil chemotaxis secretory granule membrane positive regulation of actin filament polymerization cortical actin cytoskeleton organization cortical actin cytoskeleton organization cortical actin cytoskeleton organization positive regulation of B cell proliferation SCAR complex SCAR complex activation of protein kinase activity negative regulation of interleukin-17 production negative regulation of interleukin-6 production positive regulation of cell adhesion mediated by integrin erythrocyte homeostasis negative regulation of myosin-light-chain-phosphatase activity Fc-gamma receptor signaling pathway involved in phagocytosis positive regulation of T cell proliferation positive regulation of phosphorylation response to drug T cell homeostasis negative regulation of apoptotic process neutrophil degranulation positive regulation of CD4-positive, alpha-beta T cell differentiation positive regulation of CD8-positive, alpha-beta T cell differentiation positive regulation of GTPase activity protein-containing complex binding positive regulation of B cell differentiation positive regulation of gamma-delta T cell differentiation positive regulation of lymphocyte differentiation positive regulation of erythrocyte differentiation vascular endothelial growth factor receptor signaling pathway Rac GTPase binding neuron projection morphogenesis erythrocyte development B cell receptor signaling pathway positive regulation of phagocytosis, engulfment protein-containing complex assembly extracellular exosome actin polymerization-dependent cell motility positive regulation of neutrophil chemotaxis ficolin-1-rich granule membrane |
| Ontology : EGO-EBI | cell morphogenesis B cell homeostasis myeloid cell homeostasis GTPase activator activity protein binding cytosol cytosol plasma membrane integral component of plasma membrane chemotaxis membrane cell migration maintenance of cell polarity cell projection assembly protein kinase activator activity neutrophil chemotaxis secretory granule membrane positive regulation of actin filament polymerization cortical actin cytoskeleton organization cortical actin cytoskeleton organization cortical actin cytoskeleton organization positive regulation of B cell proliferation SCAR complex SCAR complex activation of protein kinase activity negative regulation of interleukin-17 production negative regulation of interleukin-6 production positive regulation of cell adhesion mediated by integrin erythrocyte homeostasis negative regulation of myosin-light-chain-phosphatase activity Fc-gamma receptor signaling pathway involved in phagocytosis positive regulation of T cell proliferation positive regulation of phosphorylation response to drug T cell homeostasis negative regulation of apoptotic process neutrophil degranulation positive regulation of CD4-positive, alpha-beta T cell differentiation positive regulation of CD8-positive, alpha-beta T cell differentiation positive regulation of GTPase activity protein-containing complex binding positive regulation of B cell differentiation positive regulation of gamma-delta T cell differentiation positive regulation of lymphocyte differentiation positive regulation of erythrocyte differentiation vascular endothelial growth factor receptor signaling pathway Rac GTPase binding neuron projection morphogenesis erythrocyte development B cell receptor signaling pathway positive regulation of phagocytosis, engulfment protein-containing complex assembly extracellular exosome actin polymerization-dependent cell motility positive regulation of neutrophil chemotaxis ficolin-1-rich granule membrane |
| Pathways : KEGG | Regulation of actin cytoskeleton |
| NDEx Network | NCKAP1L |
| Atlas of Cancer Signalling Network | NCKAP1L |
| Wikipedia pathways | NCKAP1L |
| Orthology - Evolution |
|---|
| OrthoDB | 3071 |
| GeneTree (enSembl) | ENSG00000123338 |
| Phylogenetic Trees/Animal Genes : TreeFam | NCKAP1L |
| HOGENOM | P55160 |
| Homologs : HomoloGene | NCKAP1L |
| Homology/Alignments : Family Browser (UCSC) | NCKAP1L |
| Gene fusions - Rearrangements |
|---|
| Fusion : Quiver | NCKAP1L |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | NCKAP1L [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | NCKAP1L |
| dbVar | NCKAP1L |
| ClinVar | NCKAP1L |
| 1000_Genomes | NCKAP1L |
| Exome Variant Server | NCKAP1L |
| ExAC (Exome Aggregation Consortium) | ENSG00000123338 |
| GNOMAD Browser | ENSG00000123338 |
| Varsome Browser | NCKAP1L |
| Genetic variants : HAPMAP | 3071 |
| Genomic Variants (DGV) | NCKAP1L [DGVbeta] |
| DECIPHER | NCKAP1L [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | NCKAP1L |
| Mutations |
|---|
| ICGC Data Portal | NCKAP1L |
| TCGA Data Portal | NCKAP1L |
| Broad Tumor Portal | NCKAP1L |
| OASIS Portal | NCKAP1L [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | NCKAP1L [overview] [genome browser] [tissue] [distribution] |
| Somatic Mutations in Cancer : COSMIC3D | NCKAP1L |
| Mutations and Diseases : HGMD | NCKAP1L |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search NCKAP1L |
| DgiDB (Drug Gene Interaction Database) | NCKAP1L |
| DoCM (Curated mutations) | NCKAP1L (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | NCKAP1L (select a term) |
| intoGen | NCKAP1L |
| Cancer3D | NCKAP1L(select the gene name) |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 141180 |
| Orphanet | |
| DisGeNET | NCKAP1L |
| Medgen | NCKAP1L |
| Genetic Testing Registry | NCKAP1L
|
| NextProt | P55160 [Medical] |
| TSGene | 3071 |
| GENETests | NCKAP1L |
| Target Validation | NCKAP1L |
| Huge Navigator |
NCKAP1L [HugePedia] |
| snp3D : Map Gene to Disease | 3071 |
| BioCentury BCIQ | NCKAP1L |
| ClinGen | NCKAP1L |
| Clinical trials, drugs, therapy |
|---|
| Protein Interactions : CTD | 3071 |
| Pharm GKB Gene | PA29239 |
| Clinical trial | NCKAP1L |
| Miscellaneous |
|---|
| canSAR (ICR) | NCKAP1L (select the gene name) |
| Harmonizome | NCKAP1L |
| DataMed Index | NCKAP1L |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 17 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | NCKAP1L |
| EVEX | NCKAP1L |
| GoPubMed | NCKAP1L |
| iHOP | NCKAP1L |
