NCOA6 (nuclear receptor coactivator 6)

2004-04-01  

Identity

HGNC
LOCATION
20q11.22
LOCUSID
ALIAS
AIB3,ASC2,NRC,PRIP,RAP250,TRBP
FUSION GENES

Other Information

Locus ID:

NCBI: 23054
MIM: 605299
HGNC: 15936
Ensembl: ENSG00000198646

Variants:

dbSNP: 23054
ClinVar: 23054
TCGA: ENSG00000198646
COSMIC: NCOA6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198646ENST00000359003Q14686
ENSG00000198646ENST00000374796Q14686
ENSG00000198646ENST00000612493F6M2K2
ENSG00000198646ENST00000616167F6M2K4
ENSG00000198646ENST00000628752A0A0D9SFT8

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Mitochondrial biogenesisREACTOMER-HSA-1592230
Transcriptional activation of mitochondrial biogenesisREACTOMER-HSA-2151201
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
YAP1- and WWTR1 (TAZ)-stimulated gene expressionREACTOMER-HSA-2032785
Circadian ClockREACTOMER-HSA-400253
BMAL1:CLOCK,NPAS2 activates circadian gene expressionREACTOMER-HSA-1368108
RORA activates gene expressionREACTOMER-HSA-1368082
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)REACTOMER-HSA-400206
PPARA activates gene expressionREACTOMER-HSA-1989781
Regulation of cholesterol biosynthesis by SREBP (SREBF)REACTOMER-HSA-1655829
Activation of gene expression by SREBF (SREBP)REACTOMER-HSA-2426168
Developmental BiologyREACTOMER-HSA-1266738
Transcriptional regulation of white adipocyte differentiationREACTOMER-HSA-381340
Activation of HOX genes during differentiationREACTOMER-HSA-5619507
Activation of anterior HOX genes in hindbrain development during early embryogenesisREACTOMER-HSA-5617472

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
124829682003Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins.104
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
186604892008Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.26
207219752010Association of a common AGO1 variant with lung cancer risk: a two-stage case-control study.24
195563422009ASCOM controls farnesoid X receptor transactivation through its associated histone H3 lysine 4 methyltransferase activity.21
127244172003Activating signal cointegrator 2 required for liver lipid metabolism mediated by liver X receptors in mice.18
157645852005Characterization of activating signal cointegrator-2 as a novel transcriptional coactivator of the xenobiotic nuclear receptor constitutive androstane receptor.16
185521232008Nuclear receptor coactivator 6 mediates the synergistic activation of human cytochrome P-450 2C9 by the constitutive androstane receptor and hepatic nuclear factor-4alpha.15
149603262004Coactivator ASC-2 mediates heat shock factor 1-mediated transactivation dependent on heat shock.12
182635912008RAP250 is a coactivator in the transforming growth factor beta signaling pathway that interacts with Smad2 and Smad3.10

Citation

Dessen P

NCOA6 (nuclear receptor coactivator 6)

Atlas Genet Cytogenet Oncol Haematol. 2004-04-01

Online version: http://atlasgeneticsoncology.org/gene/41507/ncoa6