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NCOR2 (nuclear receptor corepressor 2)

Identity

Alias (NCBI)CTG26
N-CoR2
SMAP270
SMRT
SMRTE
SMRTE-tau
TNRC14
TRAC
TRAC-1
TRAC1
HGNC (Hugo) NCOR2
HGNC Alias symbSMRT
SMRTE
TRAC-1
CTG26
TNRC14
HGNC Previous namenuclear receptor co-repressor 2
LocusID (NCBI) 9612
Atlas_Id 41509
Location 12q24.31  [Link to chromosome band 12q24]
Location_base_pair Starts at 124324415 and ends at 124567612 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ANKLE2 (12q24.33) / NCOR2 (12q24.31)BMP2K (4q21.21) / NCOR2 (12q24.31)CHN1 (2q31.1) / NCOR2 (12q24.31)
HNRNPK (9q21.32) / NCOR2 (12q24.31)LAMA5 (20q13.33) / NCOR2 (12q24.31)MALAT1 (11q13.1) / NCOR2 (12q24.31)
NCOR2 (12q24.31) / DDX27 (20q13.13)NCOR2 (12q24.31) / DHX37 (12q24.31)NCOR2 (12q24.31) / ELN (7q11.23)
NCOR2 (12q24.31) / FBXO33 (14q21.1)NCOR2 (12q24.31) / FMR1NB (Xq27.3)NCOR2 (12q24.31) / GATA4 (8p23.1)
NCOR2 (12q24.31) / ITGB5 (3q21.2)NCOR2 (12q24.31) / OTUD5 (Xp11.23)NCOR2 (12q24.31) / PGC (6p21.1)
NCOR2 (12q24.31) / RPL14 (3p22.1)NCOR2 (12q24.31) / SCARB1 (12q24.31)NCOR2 (12q24.31) / TMEM132D (12q24.33)
PRRC2B (9q34.13) / NCOR2 (12q24.31)SLC4A5 (2p13.1) / NCOR2 (12q24.31)TLN1 (9p13.3) / NCOR2 (12q24.31)
ANKLE2 12q24.33 / NCOR2 12q24.31LAMA5 20q13.33 / NCOR2 12q24.31NCOR2 12q24.31 / DDX27 20q13.13
NCOR2 12q24.31 / DHX37 12q24.31NCOR2 12q24.31 / FMR1NB Xq27.3NCOR2 12q24.31 / GATA4 8p23.1
NCOR2 12q24.31 / ITGB5 3q21.2NCOR2 12q24.31 / PGC 6p21.1NCOR2 12q24.31 / SCARB1 12q24.31
NCOR2 12q24.31 / TMEM132D 12q24.33

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 28 ]
  Anaplastic large cell lymphoma, ALK-negative
ins(12;8)(p13;q11q21) ETV6/LYN
t(1;3)(q25;q27) GAS5/BCL6
t(1;12)(p36;p13) ETV6/PRDM16
t(3;3)(q25;q27) MBNL1/BCL6
t(3;3)(q27;q27) ST6GAL1/BCL6::del(3)(q27q27) ST6GAL1/BCL6
t(3;3)(q27;q28) EIF4A2/BCL6
t(3;3)(q27;q29) TFRC/BCL6
t(3;6)(q27;p21) SRSF3/BCL6
t(3;6)(q27;p21) PIM1/BCL6
t(3;6)(q27;p21)
t(3;6)(q27;p22) HIST1H4I/BCL6
t(3;6)(q27;q14) SNHG5/BCL6
t(3;6)(q27;q15) ?/BCL6
t(3;7)(q27;q32) FRA7H/BCL6
t(3;9)(q27;p13) GRHPR/BCL6
t(3;9)(q27;p24) DMRT1/BCL6
t(3;11)(q27;q23) POU2AF1/BCL6
t(3;12)(q27;p12) LRMP/BCL6
t(3;12)(q27;p13) GAPDH/BCL6
t(3;14)(q27;q32) HSP90AA1/BCL6
t(3;17)(q26;q12-21) TBL1XR1/RARA
t(3;19)(q27;q13) NAPA/BCL6
t(6;12)(q22;q24) NCOR2/ROS1
t(8;9)(q24;p13) ?/MYC
t(9;17)(p13;p12) PAX5/NCOR1
t(12;15)(p13;q25) ETV6/NTRK3 in Hematological malignancies
t(12;12)(q24;q24) NCOR2/SCARB1

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 13 ]
  t(12;15)(p13;q25) ETV6/NTRK3 in solid tumors
Lung: Translocations in Small Cell Carcinoma
t(3;12)(q21;q24) NCOR2/ITGB5
t(6;12)(p21;q24) NCOR2/PGC
t(7;12)(q11;q24) NCOR2/ELN
t(8;12)(p23;q24) NCOR2/GATA4
t(X;12)(q27;q24) NCOR2/FMR1NB
ANKLE2/NCOR2 (12q24)
NCOR2/DHX37 (12q24)
NCOR2/TMEM132D (12q24)
NCOR2/SCARB1 (12q24)
t(12;20)(q24;q13) LAMA5/NCOR2
t(12;20)(q24;q13) NCOR2/DDX27

External links

Nomenclature
HGNC (Hugo)NCOR2   7673
Cards
Entrez_Gene (NCBI)NCOR2    nuclear receptor corepressor 2
AliasesCTG26; N-CoR2; SMAP270; SMRT; 
SMRTE; SMRTE-tau; TNRC14; TRAC; TRAC-1; TRAC1
GeneCards (Weizmann)NCOR2
Ensembl hg19 (Hinxton)ENSG00000196498 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000196498 [Gene_View]  ENSG00000196498 [Sequence]  chr12:124324415-124567612 [Contig_View]  NCOR2 [Vega]
ICGC DataPortalENSG00000196498
TCGA cBioPortalNCOR2
AceView (NCBI)NCOR2
Genatlas (Paris)NCOR2
SOURCE (Princeton)NCOR2
Genetics Home Reference (NIH)NCOR2
Genomic and cartography
GoldenPath hg38 (UCSC)NCOR2  -     chr12:124324415-124567612 -  12q24.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NCOR2  -     12q24.31   [Description]    (hg19-Feb_2009)
GoldenPathNCOR2 - 12q24.31 [CytoView hg19]  NCOR2 - 12q24.31 [CytoView hg38]
ImmunoBaseENSG00000196498
genome Data Viewer NCBINCOR2 [Mapview hg19]  
OMIM600848   
Gene and transcription
Genbank (Entrez)AB209089 AF113003 AF125672 AK127788 AY965853
RefSeq transcript (Entrez)NM_001077261 NM_001206654 NM_006312
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NCOR2
Alternative Splicing GalleryENSG00000196498
Gene ExpressionNCOR2 [ NCBI-GEO ]   NCOR2 [ EBI - ARRAY_EXPRESS ]   NCOR2 [ SEEK ]   NCOR2 [ MEM ]
Gene Expression Viewer (FireBrowse)NCOR2 [ Firebrowse - Broad ]
GenevisibleExpression of NCOR2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9612
GTEX Portal (Tissue expression)NCOR2
Human Protein AtlasENSG00000196498-NCOR2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y618   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y618  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y618
Splice isoforms : SwissVarQ9Y618
PhosPhoSitePlusQ9Y618
Domaine pattern : Prosite (Expaxy)SANT (PS51293)   
Domains : Interpro (EBI)Homeobox-like_sf    N-CoR_GPS2_interact    SANT/Myb    SANT_dom   
Domain families : Pfam (Sanger)GPS2_interact (PF15784)    Myb_DNA-binding (PF00249)   
Domain families : Pfam (NCBI)pfam15784    pfam00249   
Domain families : Smart (EMBL)SANT (SM00717)  
Conserved Domain (NCBI)NCOR2
Blocks (Seattle)NCOR2
PDB (RSDB)1KKQ    1R2B    1XC5    2GPV    2L5G    2LTP    2ODD    2RT5    3R29    3R2A    4A69    4OAR    5X8Q    5X8X    5ZOO    5ZOP    6A22    6IVX   
PDB Europe1KKQ    1R2B    1XC5    2GPV    2L5G    2LTP    2ODD    2RT5    3R29    3R2A    4A69    4OAR    5X8Q    5X8X    5ZOO    5ZOP    6A22    6IVX   
PDB (PDBSum)1KKQ    1R2B    1XC5    2GPV    2L5G    2LTP    2ODD    2RT5    3R29    3R2A    4A69    4OAR    5X8Q    5X8X    5ZOO    5ZOP    6A22    6IVX   
PDB (IMB)1KKQ    1R2B    1XC5    2GPV    2L5G    2LTP    2ODD    2RT5    3R29    3R2A    4A69    4OAR    5X8Q    5X8X    5ZOO    5ZOP    6A22    6IVX   
Structural Biology KnowledgeBase1KKQ    1R2B    1XC5    2GPV    2L5G    2LTP    2ODD    2RT5    3R29    3R2A    4A69    4OAR    5X8Q    5X8X    5ZOO    5ZOP    6A22    6IVX   
SCOP (Structural Classification of Proteins)1KKQ    1R2B    1XC5    2GPV    2L5G    2LTP    2ODD    2RT5    3R29    3R2A    4A69    4OAR    5X8Q    5X8X    5ZOO    5ZOP    6A22    6IVX   
CATH (Classification of proteins structures)1KKQ    1R2B    1XC5    2GPV    2L5G    2LTP    2ODD    2RT5    3R29    3R2A    4A69    4OAR    5X8Q    5X8X    5ZOO    5ZOP    6A22    6IVX   
SuperfamilyQ9Y618
Human Protein Atlas [tissue]ENSG00000196498-NCOR2 [tissue]
Peptide AtlasQ9Y618
HPRD02910
IPIIPI00001735   IPI00878336   IPI00923596   IPI00923436   IPI00923531   IPI01017993   IPI01009189   IPI00952657   IPI00878709   IPI00952937   IPI00879066   IPI00878871   IPI00879250   IPI00879234   IPI00879606   IPI00879430   IPI00879943   IPI00939494   IPI01012202   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y618
IntAct (EBI)Q9Y618
BioGRIDNCOR2
STRING (EMBL)NCOR2
ZODIACNCOR2
Ontologies - Pathways
QuickGOQ9Y618
Ontology : AmiGOhistone deacetylase complex  negative regulation of transcription by RNA polymerase II  negative regulation of transcription by RNA polymerase II  negative regulation of transcription by RNA polymerase II  nuclear chromatin  nuclear chromatin  RNA polymerase II regulatory region sequence-specific DNA binding  chromatin binding  transcription corepressor activity  transcription corepressor activity  transcription corepressor activity  Notch binding  protein binding  nucleus  nucleus  nucleus  nucleoplasm  nucleoplasm  lactation  response to organonitrogen compound  regulation of cellular ketone metabolic process  membrane  nuclear matrix  nuclear body  transcriptional repressor complex  transcriptional repressor complex  regulation of lipid metabolic process  response to estradiol  nuclear hormone receptor binding  glucocorticoid receptor binding  histone deacetylase binding  histone deacetylase binding  sequence-specific DNA binding  estrous cycle  protein-containing complex binding  negative regulation of transcription, DNA-templated  retinoid X receptor binding  protein N-terminus binding  negative regulation of androgen receptor signaling pathway  negative regulation of production of miRNAs involved in gene silencing by miRNA  
Ontology : EGO-EBIhistone deacetylase complex  negative regulation of transcription by RNA polymerase II  negative regulation of transcription by RNA polymerase II  negative regulation of transcription by RNA polymerase II  nuclear chromatin  nuclear chromatin  RNA polymerase II regulatory region sequence-specific DNA binding  chromatin binding  transcription corepressor activity  transcription corepressor activity  transcription corepressor activity  Notch binding  protein binding  nucleus  nucleus  nucleus  nucleoplasm  nucleoplasm  lactation  response to organonitrogen compound  regulation of cellular ketone metabolic process  membrane  nuclear matrix  nuclear body  transcriptional repressor complex  transcriptional repressor complex  regulation of lipid metabolic process  response to estradiol  nuclear hormone receptor binding  glucocorticoid receptor binding  histone deacetylase binding  histone deacetylase binding  sequence-specific DNA binding  estrous cycle  protein-containing complex binding  negative regulation of transcription, DNA-templated  retinoid X receptor binding  protein N-terminus binding  negative regulation of androgen receptor signaling pathway  negative regulation of production of miRNAs involved in gene silencing by miRNA  
Pathways : KEGGNotch signaling pathway    Epstein-Barr virus infection   
NDEx NetworkNCOR2
Atlas of Cancer Signalling NetworkNCOR2
Wikipedia pathwaysNCOR2
Orthology - Evolution
OrthoDB9612
GeneTree (enSembl)ENSG00000196498
Phylogenetic Trees/Animal Genes : TreeFamNCOR2
HOGENOMQ9Y618
Homologs : HomoloGeneNCOR2
Homology/Alignments : Family Browser (UCSC)NCOR2
Gene fusions - Rearrangements
Fusion : MitelmanANKLE2/NCOR2 [12q24.33/12q24.31]  
Fusion : MitelmanLAMA5/NCOR2 [20q13.33/12q24.31]  
Fusion : MitelmanNCOR2/DDX27 [12q24.31/20q13.13]  
Fusion : MitelmanNCOR2/DHX37 [12q24.31/12q24.31]  
Fusion : MitelmanNCOR2/ELN [12q24.31/7q11.23]  
Fusion : MitelmanNCOR2/FMR1NB [12q24.31/Xq27.3]  
Fusion : MitelmanNCOR2/GATA4 [12q24.31/8p23.1]  
Fusion : MitelmanNCOR2/ITGB5 [12q24.31/3q21.2]  
Fusion : MitelmanNCOR2/PGC [12q24.31/6p21.1]  
Fusion : MitelmanNCOR2/SCARB1 [12q24.31/12q24.31]  
Fusion : MitelmanNCOR2/TMEM132D [12q24.31/12q24.33]  
Fusion PortalANKLE2 12q24.33 NCOR2 12q24.31 LGG
Fusion PortalLAMA5 20q13.33 NCOR2 12q24.31 OV
Fusion PortalNCOR2 12q24.31 DDX27 20q13.13 HNSC
Fusion PortalNCOR2 12q24.31 DHX37 12q24.31 GBM
Fusion PortalNCOR2 12q24.31 FMR1NB Xq27.3 KIRC
Fusion PortalNCOR2 12q24.31 GATA4 8p23.1 LGG
Fusion PortalNCOR2 12q24.31 ITGB5 3q21.2 BRCA
Fusion PortalNCOR2 12q24.31 PGC 6p21.1 LUAD
Fusion PortalNCOR2 12q24.31 SCARB1 12q24.31 BRCA LAML LUAD
Fusion PortalNCOR2 12q24.31 TMEM132D 12q24.33 LGG
Fusion : QuiverNCOR2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNCOR2 [hg38]
dbVarNCOR2
ClinVarNCOR2
MonarchNCOR2
1000_GenomesNCOR2 
Exome Variant ServerNCOR2
GNOMAD BrowserENSG00000196498
Varsome BrowserNCOR2
Genomic Variants (DGV)NCOR2 [DGVbeta]
DECIPHERNCOR2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNCOR2 
Mutations
ICGC Data PortalNCOR2 
TCGA Data PortalNCOR2 
Broad Tumor PortalNCOR2
OASIS PortalNCOR2 [ Somatic mutations - Copy number]
Cancer Gene: CensusNCOR2 
Somatic Mutations in Cancer : COSMICNCOR2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNCOR2
Mutations and Diseases : HGMDNCOR2
intOGen PortalNCOR2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NCOR2
DgiDB (Drug Gene Interaction Database)NCOR2
DoCM (Curated mutations)NCOR2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NCOR2 (select a term)
intoGenNCOR2
Cancer3DNCOR2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600848   
Orphanet
DisGeNETNCOR2
MedgenNCOR2
Genetic Testing Registry NCOR2
NextProtQ9Y618 [Medical]
GENETestsNCOR2
Target ValidationNCOR2
Huge Navigator NCOR2 [HugePedia]
ClinGenNCOR2
Clinical trials, drugs, therapy
MyCancerGenomeNCOR2
Protein Interactions : CTD
Pharm GKB GenePA31478
PharosQ9Y618
Clinical trialNCOR2
Miscellaneous
canSAR (ICR)NCOR2 (select the gene name)
HarmonizomeNCOR2
DataMed IndexNCOR2
Probes
Litterature
PubMed297 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXNCOR2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Jan 1 18:28:26 CET 2021
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