NCR1 (natural cytotoxicity triggering receptor 1)

2007-02-01  

Identity

HGNC
NCR1
LOCATION
19q13.42
LOCUSID
9437
ALIAS
CD335,LY94,NK-p46,NKP46
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9437
MIM: 604530
HGNC: 6731
Ensembl: ENSG00000189430

Variants:

dbSNP: 9437
ClinVar: 9437
TCGA: ENSG00000189430
COSMIC: NCR1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000189430ENST00000291890A0A0A0MQZ0
ENSG00000189430ENST00000338835A0A0A0MR94
ENSG00000189430ENST00000350790O76036
ENSG00000189430ENST00000357397O76036
ENSG00000189430ENST00000594765A0A0A0MTU0
ENSG00000189430ENST00000598576M0QYD1

Expression (GTEx)

0
1
2
3
4
5
6
7
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Natural killer cell mediated cytotoxicityKEGGko04650
Natural killer cell mediated cytotoxicityKEGGhsa04650
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933

References

Pubmed IDYearTitleCitations
178756812007The requirement for DNAM-1, NKG2D, and NKp46 in the natural killer cell-mediated killing of myeloma cells.103
153281552005HLA class I, NKG2D, and natural cytotoxicity receptors regulate multiple myeloma cell recognition by natural killer cells.102
145040812004The mechanisms controlling the recognition of tumor- and virus-infected cells by NKp46.91
206389362010Imbalance of NKp44(+)NKp46(-) and NKp44(-)NKp46(+) natural killer cells in the intestinal mucosa of patients with Crohn's disease.78
200236612010The activating receptor NKp46 is essential for the development of type 1 diabetes.67
156571832005Ligands for natural killer cell-activating receptors are expressed upon the maturation of normal myelomonocytic cells but at low levels in acute myeloid leukemias.60
170565482006Vimentin expressed on Mycobacterium tuberculosis-infected human monocytes is involved in binding to the NKp46 receptor.59
210305632011NKp46 and DNAM-1 NK-cell receptors drive the response to human cytomegalovirus-infected myeloid dendritic cells overcoming viral immune evasion strategies.52
187139712008Critical and differential roles of NKp46- and NKp30-activating receptors expressed by uterine NK cells in early pregnancy.49
225321902012Natural killer p46High expression defines a natural killer cell subset that is potentially involved in control of hepatitis C virus replication and modulation of liver fibrosis.48

Citation

Dessen P

NCR1 (natural cytotoxicity triggering receptor 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45588/ncr1