NCS1 (neuronal calcium sensor 1)

2018-07-01  

Identity

HGNC
LOCATION
9q34.11
LOCUSID
ALIAS
FLUP,FREQ
FUSION GENES

Other Information

Locus ID:

NCBI: 23413
MIM: 603315
HGNC: 3953
Ensembl: ENSG00000107130

Variants:

dbSNP: 23413
ClinVar: 23413
TCGA: ENSG00000107130
COSMIC: NCS1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000107130ENST00000372398P62166
ENSG00000107130ENST00000372398A0A024R8B2
ENSG00000107130ENST00000630865P62166

Expression (GTEx)

0
50
100
150
200
250
300
350
400

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
124963482003Up-regulation of neuronal calcium sensor-1 (NCS-1) in the prefrontal cortex of schizophrenic and bipolar patients.60
249342882014Cav1.3 channels control D2-autoreceptor responses via NCS-1 in substantia nigra dopamine neurons.40
204680642010Association study of 182 candidate genes in anorexia nervosa.30
204798902010Structural and functional deficits in a neuronal calcium sensor-1 mutant identified in a case of autistic spectrum disorder.29
145124212003Conservation of regulatory function in calcium-binding proteins: human frequenin (neuronal calcium sensor-1) associates productively with yeast phosphatidylinositol 4-kinase isoform, Pik1.18
222273932012The C-terminal tail of human neuronal calcium sensor 1 regulates the conformational stability of the Ca²⁺₋ activated state.18
176729182007Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns.17
217377922011Neuronal calcium sensor-1 promotes immature heart function and hypertrophy by enhancing Ca2+ signals.17
251571712014Direct single-molecule observation of calcium-dependent misfolding in human neuronal calcium sensor-1.16
164020812006Interaction between variation in the D2 dopamine receptor (DRD2) and the neuronal calcium sensor-1 (FREQ) genes in predicting response to nicotine replacement therapy for tobacco dependence.15

Citation

Dessen P

NCS1 (neuronal calcium sensor 1)

Atlas Genet Cytogenet Oncol Haematol. 2018-07-01

Online version: http://atlasgeneticsoncology.org/gene/57425/ncs1