NDEL1 (nudE neurodevelopment protein 1 like 1)

2016-10-01  

Identity

HGNC
LOCATION
17p13.1
LOCUSID
ALIAS
EOPA,MITAP1,NDE1L1,NDE2,NUDEL
FUSION GENES

Other Information

Locus ID:

NCBI: 81565
MIM: 607538
HGNC: 17620
Ensembl: ENSG00000166579

Variants:

dbSNP: 81565
ClinVar: 81565
TCGA: ENSG00000166579
COSMIC: NDEL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166579ENST00000334527Q9GZM8
ENSG00000166579ENST00000380025A6NIZ0
ENSG00000166579ENST00000402554Q9GZM8
ENSG00000166579ENST00000580012J3QL31
ENSG00000166579ENST00000580237J3QRD2
ENSG00000166579ENST00000581679J3QSD2
ENSG00000166579ENST00000582277J3QRZ1
ENSG00000166579ENST00000582490J3KT16
ENSG00000166579ENST00000582665J3QL85
ENSG00000166579ENST00000582812J3KRK9
ENSG00000166579ENST00000584866J3KSF2
ENSG00000166579ENST00000585098J3QLD0

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ForminsREACTOMER-HSA-5663220
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic PrometaphaseREACTOMER-HSA-68877
Resolution of Sister Chromatid CohesionREACTOMER-HSA-2500257
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Separation of Sister ChromatidsREACTOMER-HSA-2467813

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
125061982003Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth.126
187847522008LIS1 and NDEL1 coordinate the plus-end-directed transport of cytoplasmic dynein.90
176007102007Cenp-F links kinetochores to Ndel1/Nde1/Lis1/dynein microtubule motor complexes.81
223738682012Multiple modes of cytoplasmic dynein regulation.74
210928592010Genetic mosaic dissection of Lis1 and Ndel1 in neuronal migration.72
170604492007NDEL1 phosphorylation by Aurora-A kinase is essential for centrosomal maturation, separation, and TACC3 recruitment.64
200483382010Functional interplay between LIS1, NDE1 and NDEL1 in dynein-dependent organelle positioning.60
184008832008Insolubility of disrupted-in-schizophrenia 1 disrupts oligomer-dependent interactions with nuclear distribution element 1 and is associated with sporadic mental disease.57
191986022009Requirement for Nudel and dynein for assembly of the lamin B spindle matrix.57
125564842003Human Nudel and NudE as regulators of cytoplasmic dynein in poleward protein transport along the mitotic spindle.51

Citation

Dessen P

NDEL1 (nudE neurodevelopment protein 1 like 1)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56336/ndel1