NDUFB7 (NADH:ubiquinone oxidoreductase subunit B7)

2014-11-01  

Identity

HGNC
LOCATION
19p13.12
LOCUSID
ALIAS
B18,CI-B18
FUSION GENES

Other Information

Locus ID:

NCBI: 4713
MIM: 603842
HGNC: 7702
Ensembl: ENSG00000099795

Variants:

dbSNP: 4713
ClinVar: 4713
TCGA: ENSG00000099795
COSMIC: NDUFB7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000099795ENST00000215565P17568
ENSG00000099795ENST00000593353M0R3B8

Expression (GTEx)

0
50
100
150
200
250
300
350

Pathways

PathwaySourceExternal ID
Oxidative phosphorylationKEGGko00190
Alzheimer's diseaseKEGGko05010
Huntington's diseaseKEGGko05016
Oxidative phosphorylationKEGGhsa00190
Alzheimer's diseaseKEGGhsa05010
Parkinson's diseaseKEGGhsa05012
Huntington's diseaseKEGGhsa05016
Metabolic pathwaysKEGGhsa01100
NADH dehydrogenase (ubiquinone) 1 beta subcomplexKEGGhsa_M00147
Non-alcoholic fatty liver disease (NAFLD)KEGGhsa04932
Non-alcoholic fatty liver disease (NAFLD)KEGGko04932
NADH dehydrogenase (ubiquinone) 1 beta subcomplexKEGGM00147
MetabolismREACTOMER-HSA-1430728
The citric acid (TCA) cycle and respiratory electron transportREACTOMER-HSA-1428517
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.REACTOMER-HSA-163200
Respiratory electron transportREACTOMER-HSA-611105
Complex I biogenesisREACTOMER-HSA-6799198

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
176013502007A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.27
189772412008Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey.20
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
213101502011NDUFB7 and NDUFA8 are located at the intermembrane surface of complex I.12
213101502011NDUFB7 and NDUFA8 are located at the intermembrane surface of complex I.12
193430462009Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.3

Citation

Dessen P

NDUFB7 (NADH:ubiquinone oxidoreductase subunit B7)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/70778/ndufb7