Atlas of Genetics and Cytogenetics in Oncology and Haematology

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NDUFS6 (NADH:ubiquinone oxidoreductase subunit S6)

Identity

Alias_namesNADH dehydrogenase (ubiquinone) Fe-S protein 6 (13kD) (NADH-coenzyme Q reductase)
NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase)
Alias_symbol (synonym)CI-13kA
Other aliasCI-13kD-A
CI13KDA
MC1DN9
HGNC (Hugo) NDUFS6
LocusID (NCBI) 4726
Atlas_Id 54496
Location 5p15.33  [Link to chromosome band 5p15]
Location_base_pair Starts at 1801382 and ends at 1816051 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
NDUFS6 (5p15.33) / ACTB (7p22.1)NDUFS6 (5p15.33) / GGA2 (16p12.2)NDUFS6 (5p15.33) / GNAS (20q13.32)
NDUFS6 (5p15.33) / NFE2L2 (2q31.2)PAPD7 (5p15.31) / NDUFS6 (5p15.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(5;7)(p15;p22) NDUFS6/ACTB

External links

Nomenclature
HGNC (Hugo)NDUFS6   7713
Cards
Entrez_Gene (NCBI)NDUFS6  4726  NADH:ubiquinone oxidoreductase subunit S6
AliasesCI-13kA; CI-13kD-A; CI13KDA; MC1DN9
GeneCards (Weizmann)NDUFS6
Ensembl hg19 (Hinxton)ENSG00000145494 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000145494 [Gene_View]  ENSG00000145494 [Sequence]  chr5:1801382-1816051 [Contig_View]  NDUFS6 [Vega]
ICGC DataPortalENSG00000145494
TCGA cBioPortalNDUFS6
AceView (NCBI)NDUFS6
Genatlas (Paris)NDUFS6
WikiGenes4726
SOURCE (Princeton)NDUFS6
Genetics Home Reference (NIH)NDUFS6
Genomic and cartography
GoldenPath hg38 (UCSC)NDUFS6  -     chr5:1801382-1816051 +  5p15.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NDUFS6  -     5p15.33   [Description]    (hg19-Feb_2009)
GoldenPathNDUFS6 - 5p15.33 [CytoView hg19]  NDUFS6 - 5p15.33 [CytoView hg38]
ImmunoBaseENSG00000145494
Mapping of homologs : NCBINDUFS6 [Mapview hg19]  NDUFS6 [Mapview hg38]
OMIM603848   618232   
Gene and transcription
Genbank (Entrez)AF044959 AK022503 BC038664 BC046155 BE900424
RefSeq transcript (Entrez)NM_004553
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NDUFS6
Cluster EST : UnigeneHs.408257 [ NCBI ]
CGAP (NCI)Hs.408257
Alternative Splicing GalleryENSG00000145494
Gene ExpressionNDUFS6 [ NCBI-GEO ]   NDUFS6 [ EBI - ARRAY_EXPRESS ]   NDUFS6 [ SEEK ]   NDUFS6 [ MEM ]
Gene Expression Viewer (FireBrowse)NDUFS6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4726
GTEX Portal (Tissue expression)NDUFS6
Human Protein AtlasENSG00000145494-NDUFS6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75380   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75380  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75380
Splice isoforms : SwissVarO75380
Catalytic activity : Enzyme1.6.99.3|1.6.5.3 [ Enzyme-Expasy ]   1.6.99.3|1.6.5.31.6.99.3|1.6.5.3 [ IntEnz-EBI ]   1.6.99.3|1.6.5.3 [ BRENDA ]   1.6.99.3|1.6.5.3 [ KEGG ]   
PhosPhoSitePlusO75380
Domains : Interpro (EBI)NDUFS6    Znf_CHCC   
Domain families : Pfam (Sanger)zf-CHCC (PF10276)   
Domain families : Pfam (NCBI)pfam10276   
Conserved Domain (NCBI)NDUFS6
DMDM Disease mutations4726
Blocks (Seattle)NDUFS6
PDB (RSDB)5XTB    5XTD    5XTH    5XTI   
PDB Europe5XTB    5XTD    5XTH    5XTI   
PDB (PDBSum)5XTB    5XTD    5XTH    5XTI   
PDB (IMB)5XTB    5XTD    5XTH    5XTI   
Structural Biology KnowledgeBase5XTB    5XTD    5XTH    5XTI   
SCOP (Structural Classification of Proteins)5XTB    5XTD    5XTH    5XTI   
CATH (Classification of proteins structures)5XTB    5XTD    5XTH    5XTI   
SuperfamilyO75380
Human Protein Atlas [tissue]ENSG00000145494-NDUFS6 [tissue]
Peptide AtlasO75380
HPRD10356
IPIIPI00025344   IPI00965997   
Protein Interaction databases
DIP (DOE-UCLA)O75380
IntAct (EBI)O75380
FunCoupENSG00000145494
BioGRIDNDUFS6
STRING (EMBL)NDUFS6
ZODIACNDUFS6
Ontologies - Pathways
QuickGOO75380
Ontology : AmiGOmitochondrial inner membrane  mitochondrial respiratory chain complex I  mitochondrial respiratory chain complex I  mitochondrial respiratory chain complex I  mitochondrial electron transport, NADH to ubiquinone  mitochondrial electron transport, NADH to ubiquinone  mitochondrial electron transport, NADH to ubiquinone  fatty acid metabolic process  muscle contraction  NADH dehydrogenase (ubiquinone) activity  electron transfer activity  multicellular organism aging  mitochondrial respiratory chain complex I assembly  multicellular organism growth  reproductive system development  mitochondrion morphogenesis  cardiovascular system development  
Ontology : EGO-EBImitochondrial inner membrane  mitochondrial respiratory chain complex I  mitochondrial respiratory chain complex I  mitochondrial respiratory chain complex I  mitochondrial electron transport, NADH to ubiquinone  mitochondrial electron transport, NADH to ubiquinone  mitochondrial electron transport, NADH to ubiquinone  fatty acid metabolic process  muscle contraction  NADH dehydrogenase (ubiquinone) activity  electron transfer activity  multicellular organism aging  mitochondrial respiratory chain complex I assembly  multicellular organism growth  reproductive system development  mitochondrion morphogenesis  cardiovascular system development  
Pathways : KEGGOxidative phosphorylation    Non-alcoholic fatty liver disease (NAFLD)    Alzheimer's disease    Parkinson's disease    Huntington's disease   
NDEx NetworkNDUFS6
Atlas of Cancer Signalling NetworkNDUFS6
Wikipedia pathwaysNDUFS6
Orthology - Evolution
OrthoDB4726
GeneTree (enSembl)ENSG00000145494
Phylogenetic Trees/Animal Genes : TreeFamNDUFS6
HOGENOMO75380
Homologs : HomoloGeneNDUFS6
Homology/Alignments : Family Browser (UCSC)NDUFS6
Gene fusions - Rearrangements
Fusion : MitelmanNDUFS6/ACTB [5p15.33/7p22.1]  
Fusion : QuiverNDUFS6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNDUFS6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NDUFS6
dbVarNDUFS6
ClinVarNDUFS6
1000_GenomesNDUFS6 
Exome Variant ServerNDUFS6
ExAC (Exome Aggregation Consortium)ENSG00000145494
GNOMAD BrowserENSG00000145494
Varsome BrowserNDUFS6
Genetic variants : HAPMAP4726
Genomic Variants (DGV)NDUFS6 [DGVbeta]
DECIPHERNDUFS6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNDUFS6 
Mutations
ICGC Data PortalNDUFS6 
TCGA Data PortalNDUFS6 
Broad Tumor PortalNDUFS6
OASIS PortalNDUFS6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNDUFS6  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNDUFS6
Mutations and Diseases : HGMDNDUFS6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch NDUFS6
DgiDB (Drug Gene Interaction Database)NDUFS6
DoCM (Curated mutations)NDUFS6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NDUFS6 (select a term)
intoGenNDUFS6
Cancer3DNDUFS6(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603848    618232   
Orphanet369   
DisGeNETNDUFS6
MedgenNDUFS6
Genetic Testing Registry NDUFS6
NextProtO75380 [Medical]
TSGene4726
GENETestsNDUFS6
Target ValidationNDUFS6
Huge Navigator NDUFS6 [HugePedia]
snp3D : Map Gene to Disease4726
BioCentury BCIQNDUFS6
ClinGenNDUFS6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4726
Chemical/Pharm GKB GenePA31523
Clinical trialNDUFS6
Miscellaneous
canSAR (ICR)NDUFS6 (select the gene name)
DataMed IndexNDUFS6
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNDUFS6
EVEXNDUFS6
GoPubMedNDUFS6
iHOPNDUFS6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 17:57:39 CET 2019
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