Atlas of Genetics and Cytogenetics in Oncology and Haematology

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NDUFS8 (NADH:ubiquinone oxidoreductase core subunit S8)

Identity

Alias_namesNADH dehydrogenase (ubiquinone) Fe-S protein 8 (23kD) (NADH-coenzyme Q reductase)
NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)
Alias_symbol (synonym)TYKY
CI-23k
Other aliasCI23KD
MC1DN2
HGNC (Hugo) NDUFS8
LocusID (NCBI) 4728
Atlas_Id 57464
Location 11q13.2  [Link to chromosome band 11q13]
Location_base_pair Starts at 68030617 and ends at 68036647 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)NDUFS8   7715
Cards
Entrez_Gene (NCBI)NDUFS8  4728  NADH:ubiquinone oxidoreductase core subunit S8
AliasesCI-23k; CI23KD; MC1DN2; TYKY
GeneCards (Weizmann)NDUFS8
Ensembl hg19 (Hinxton)ENSG00000110717 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000110717 [Gene_View]  ENSG00000110717 [Sequence]  chr11:68030617-68036647 [Contig_View]  NDUFS8 [Vega]
ICGC DataPortalENSG00000110717
TCGA cBioPortalNDUFS8
AceView (NCBI)NDUFS8
Genatlas (Paris)NDUFS8
WikiGenes4728
SOURCE (Princeton)NDUFS8
Genetics Home Reference (NIH)NDUFS8
Genomic and cartography
GoldenPath hg38 (UCSC)NDUFS8  -     chr11:68030617-68036647 +  11q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NDUFS8  -     11q13.2   [Description]    (hg19-Feb_2009)
GoldenPathNDUFS8 - 11q13.2 [CytoView hg19]  NDUFS8 - 11q13.2 [CytoView hg38]
ImmunoBaseENSG00000110717
Mapping of homologs : NCBINDUFS8 [Mapview hg19]  NDUFS8 [Mapview hg38]
OMIM602141   618222   
Gene and transcription
Genbank (Entrez)AK002110 AK223114 AK302449 AK314546 BC119753
RefSeq transcript (Entrez)NM_002496
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NDUFS8
Cluster EST : UnigeneHs.90443 [ NCBI ]
CGAP (NCI)Hs.90443
Alternative Splicing GalleryENSG00000110717
Gene ExpressionNDUFS8 [ NCBI-GEO ]   NDUFS8 [ EBI - ARRAY_EXPRESS ]   NDUFS8 [ SEEK ]   NDUFS8 [ MEM ]
Gene Expression Viewer (FireBrowse)NDUFS8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4728
GTEX Portal (Tissue expression)NDUFS8
Human Protein AtlasENSG00000110717-NDUFS8 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00217   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO00217  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO00217
Splice isoforms : SwissVarO00217
Catalytic activity : Enzyme1.6.5.3 [ Enzyme-Expasy ]   1.6.5.31.6.5.3 [ IntEnz-EBI ]   1.6.5.3 [ BRENDA ]   1.6.5.3 [ KEGG ]   
PhosPhoSitePlusO00217
Domaine pattern : Prosite (Expaxy)4FE4S_FER_1 (PS00198)    4FE4S_FER_2 (PS51379)   
Domains : Interpro (EBI)4Fe4S_Fe-S-bd    4Fe4S_Fe_S_CS    NADH_quinone_OxRdtase_chainI   
Domain families : Pfam (Sanger)Fer4_7 (PF12838)   
Domain families : Pfam (NCBI)pfam12838   
Conserved Domain (NCBI)NDUFS8
DMDM Disease mutations4728
Blocks (Seattle)NDUFS8
PDB (RSDB)5XTB    5XTD    5XTH    5XTI   
PDB Europe5XTB    5XTD    5XTH    5XTI   
PDB (PDBSum)5XTB    5XTD    5XTH    5XTI   
PDB (IMB)5XTB    5XTD    5XTH    5XTI   
Structural Biology KnowledgeBase5XTB    5XTD    5XTH    5XTI   
SCOP (Structural Classification of Proteins)5XTB    5XTD    5XTH    5XTI   
CATH (Classification of proteins structures)5XTB    5XTD    5XTH    5XTI   
SuperfamilyO00217
Human Protein Atlas [tissue]ENSG00000110717-NDUFS8 [tissue]
Peptide AtlasO00217
IPIIPI00010845   IPI00908766   IPI00977785   IPI00980544   IPI00983992   IPI00982019   IPI00984633   IPI01026455   IPI00977184   IPI00983459   
Protein Interaction databases
DIP (DOE-UCLA)O00217
IntAct (EBI)O00217
FunCoupENSG00000110717
BioGRIDNDUFS8
STRING (EMBL)NDUFS8
ZODIACNDUFS8
Ontologies - Pathways
QuickGOO00217
Ontology : AmiGONADH dehydrogenase activity  NADH dehydrogenase activity  mitochondrion  mitochondrial respiratory chain complex I  mitochondrial respiratory chain complex I  mitochondrial respiratory chain complex I  mitochondrial respiratory chain complex I  mitochondrial matrix  mitochondrial electron transport, NADH to ubiquinone  mitochondrial electron transport, NADH to ubiquinone  mitochondrial electron transport, NADH to ubiquinone  response to oxidative stress  NADH dehydrogenase (ubiquinone) activity  NADH dehydrogenase (ubiquinone) activity  aerobic respiration  mitochondrial respiratory chain complex I assembly  mitochondrial respiratory chain complex I assembly  mitochondrial respiratory chain complex I assembly  metal ion binding  4 iron, 4 sulfur cluster binding  
Ontology : EGO-EBINADH dehydrogenase activity  NADH dehydrogenase activity  mitochondrion  mitochondrial respiratory chain complex I  mitochondrial respiratory chain complex I  mitochondrial respiratory chain complex I  mitochondrial respiratory chain complex I  mitochondrial matrix  mitochondrial electron transport, NADH to ubiquinone  mitochondrial electron transport, NADH to ubiquinone  mitochondrial electron transport, NADH to ubiquinone  response to oxidative stress  NADH dehydrogenase (ubiquinone) activity  NADH dehydrogenase (ubiquinone) activity  aerobic respiration  mitochondrial respiratory chain complex I assembly  mitochondrial respiratory chain complex I assembly  mitochondrial respiratory chain complex I assembly  metal ion binding  4 iron, 4 sulfur cluster binding  
Pathways : KEGGOxidative phosphorylation    Non-alcoholic fatty liver disease (NAFLD)    Alzheimer's disease    Parkinson's disease    Huntington's disease   
NDEx NetworkNDUFS8
Atlas of Cancer Signalling NetworkNDUFS8
Wikipedia pathwaysNDUFS8
Orthology - Evolution
OrthoDB4728
GeneTree (enSembl)ENSG00000110717
Phylogenetic Trees/Animal Genes : TreeFamNDUFS8
HOGENOMO00217
Homologs : HomoloGeneNDUFS8
Homology/Alignments : Family Browser (UCSC)NDUFS8
Gene fusions - Rearrangements
Fusion : QuiverNDUFS8
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNDUFS8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NDUFS8
dbVarNDUFS8
ClinVarNDUFS8
1000_GenomesNDUFS8 
Exome Variant ServerNDUFS8
ExAC (Exome Aggregation Consortium)ENSG00000110717
GNOMAD BrowserENSG00000110717
Varsome BrowserNDUFS8
Genetic variants : HAPMAP4728
Genomic Variants (DGV)NDUFS8 [DGVbeta]
DECIPHERNDUFS8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNDUFS8 
Mutations
ICGC Data PortalNDUFS8 
TCGA Data PortalNDUFS8 
Broad Tumor PortalNDUFS8
OASIS PortalNDUFS8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNDUFS8  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNDUFS8
Mutations and Diseases : HGMDNDUFS8
BioMutasearch NDUFS8
DgiDB (Drug Gene Interaction Database)NDUFS8
DoCM (Curated mutations)NDUFS8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NDUFS8 (select a term)
intoGenNDUFS8
Cancer3DNDUFS8(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602141    618222   
Orphanet
DisGeNETNDUFS8
MedgenNDUFS8
Genetic Testing Registry NDUFS8
NextProtO00217 [Medical]
TSGene4728
GENETestsNDUFS8
Target ValidationNDUFS8
Huge Navigator NDUFS8 [HugePedia]
snp3D : Map Gene to Disease4728
BioCentury BCIQNDUFS8
ClinGenNDUFS8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4728
Chemical/Pharm GKB GenePA31525
Clinical trialNDUFS8
Miscellaneous
canSAR (ICR)NDUFS8 (select the gene name)
DataMed IndexNDUFS8
Probes
Litterature
PubMed47 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNDUFS8
EVEXNDUFS8
GoPubMedNDUFS8
iHOPNDUFS8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 17:57:39 CET 2019
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