NECTIN1 (nectin cell adhesion molecule 1)

2015-03-01  

Identity

HGNC
LOCATION
11q23.3
LOCUSID
ALIAS
CD111,CLPED1,ED4,HIgR,HV1S,HVEC,OFC7,PRR,PRR1,PVRL1,PVRR,PVRR1,SK-12,nectin-1
FUSION GENES

Other Information

Locus ID:

NCBI: 5818
MIM: 600644
HGNC: 9706
Ensembl: ENSG00000110400

Variants:

dbSNP: 5818
ClinVar: 5818
TCGA: ENSG00000110400
COSMIC: NECTIN1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000110400ENST00000264025Q15223
ENSG00000110400ENST00000340882Q15223
ENSG00000110400ENST00000341398Q15223

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Adherens junctionKEGGko04520
Cell adhesion molecules (CAMs)KEGGhsa04514
Adherens junctionKEGGhsa04520
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
Cell-Cell communicationREACTOMER-HSA-1500931
Cell junction organizationREACTOMER-HSA-446728
Cell-cell junction organizationREACTOMER-HSA-421270
Adherens junctions interactionsREACTOMER-HSA-418990
Nectin/Necl trans heterodimerizationREACTOMER-HSA-420597

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
129155682003Specific association of glycoprotein B with lipid rafts during herpes simplex virus entry.92
219802942011Structure of herpes simplex virus glycoprotein D bound to the human receptor nectin-1.82
151105262004Comparative usage of herpesvirus entry mediator A and nectin-1 by laboratory strains and clinical isolates of herpes simplex virus.69
158578342005Regulation of E-cadherin endocytosis by nectin through afadin, Rap1, and p120ctn.62
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
120725192002Disruption of adherens junctions liberates nectin-1 to serve as receptor for herpes simplex virus and pseudorabies virus entry.40
180769652008The herpes simplex virus receptor nectin-1 is down-regulated after trans-interaction with glycoprotein D.34
188036662008Role for nectin-1 in herpes simplex virus 1 entry and spread in human retinal pigment epithelial cells.32
170056572006Access to nectin favors herpes simplex virus infection at the apical surface of polarized human epithelial cells.30
171647812007Nectin-1 expression by squamous cell carcinoma is a predictor of herpes oncolytic sensitivity.30

Citation

Dessen P

NECTIN1 (nectin cell adhesion molecule 1)

Atlas Genet Cytogenet Oncol Haematol. 2015-03-01

Online version: http://atlasgeneticsoncology.org/gene/55660/nectin1