Atlas of Genetics and Cytogenetics in Oncology and Haematology

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   
X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

NEDD4 (neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase)

Identity

Other namesNEDD4-1
RPF1
HGNC (Hugo) NEDD4
LocusID (NCBI) 4734
Location 15q21.3
Location_base_pair Starts at 56119122 and ends at 56285835 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)NEDD4   7727
Entrez_Gene (NCBI)NEDD4  4734  neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
Cards
GeneCards (Weizmann)NEDD4
Ensembl (Hinxton)ENSG00000069869 [Gene_View]  chr15:56119122-56285835 [Contig_View]  NEDD4 [Vega]
AceView (NCBI)NEDD4
Genatlas (Paris)NEDD4
SOURCE (Stanford)NM_006154 NM_198400
Genomic and cartography
GoldenPath (UCSC)NEDD4  -  15q21.3   chr15:56119122-56285835 -  15q21.3   [Description]    (hg19-Feb_2009)
EnsemblNEDD4 - 15q21.3 [CytoView]
Mapping of homologs : NCBINEDD4 [Mapview]
OMIM602278   
Gene and transcription
Genbank (Entrez)AK304394 AK307541 AL832063 AL832359 AL833293
RefSeq transcript (SRS)NM_006154 NM_198400
RefSeq transcript (Entrez)NM_006154 NM_198400
RefSeq genomic (SRS)AC_000147 NC_000015 NC_018926 NT_010194 NW_001838218 NW_004078084
RefSeq genomic (Entrez)AC_000147 NC_000015 NC_018926 NT_010194 NW_001838218 NW_004078084
Consensus coding sequences : CCDS (NCBI)NEDD4
Cluster EST : UnigeneHs.1565 [ SRS ] Hs.1565 [ NCBI ]
CGAP (NCI)Hs.1565
Alternative Splicing : Fast-db (Paris)GSHG0010445
Alternative Splicing GalleryENSG00000069869
Gene ExpressionNEDD4 [ NCBI-GEO ]   NEDD4 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP46934 (SRS) P46934 (Uniprot)
NextProtP46934
With graphics : InterProP46934
Splice isoforms : SwissVarP46934(Swissvar)
Domaine pattern : Prosite (SRS)HECT (PS50237)    WW_DOMAIN_1 (PS01159)    WW_DOMAIN_2 (PS50020)   
Domaine pattern : Prosite (Expaxy)HECT (PS50237)    WW_DOMAIN_1 (PS01159)    WW_DOMAIN_2 (PS50020)   
Domains : Interpro (SRS)HECT    WW_dom   
Domains : Interpro (EBI)HECT    WW_dom   
Related proteins : CluSTrP46934
Domain families : Pfam (SRS)HECT (PF00632)    WW (PF00397)   
Domain families : Pfam (Sanger)HECT (PF00632)    WW (PF00397)   
Domain families : Pfam (NCBI)pfam00632    pfam00397   
Domain families : Smart (EMBL)HECTc (SM00119)  WW (SM00456)  
DMDM4734
Blocks (Seattle)P46934
PDB (SRS)2KPZ    2KQ0    2XBB    2XBF    3B7Y   
PDB (PDBSum)2KPZ    2KQ0    2XBB    2XBF    3B7Y   
PDB (IMB)2KPZ    2KQ0    2XBB    2XBF    3B7Y   
PDB (RSDB)2KPZ    2KQ0    2XBB    2XBF    3B7Y   
Human Protein AtlasENSG00000069869
HPRD03786
IPIIPI00945379   IPI00969091   IPI00384495   IPI00940829   IPI00964065   IPI01011003   IPI00964317   IPI00967965   
Protein Interaction databases
DIP (DOE-UCLA)P46934
IntAct (EBI)P46934
FunCoupENSG00000069869
REACTOMENEDD4
Protein Interaction Database4734
BioGRIDNEDD4
InParanoidP46934
Interologous Interaction database P46934
IntegromeDBNEDD4
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)NEDD4
SNP (GeneSNP Utah)NEDD4
SNP : HGBaseNEDD4
Genetic variants : HAPMAPNEDD4
Somatic Mutations in Cancer : COSMICNEDD4 
CONAN: Copy Number AnalysisNEDD4 
Mutations and Diseases : HGMDNEDD4
OMIM602278   
GENETests602278   
Disease Genetic AssociationNEDD4
Huge Navigator NEDD4 [HugePedia]  NEDD4 [HugeCancerGEM]
Genomic VariantsNEDD4  NEDD4 [DGVbeta]
ClinVarNEDD4
snp3D : Map Gene to Disease4734
General knowledge
Homologs : HomoloGeneNEDD4
Homology/Alignments : Family Browser (UCSC)NEDD4
Phylogenetic Trees/Animal Genes : TreeFamNEDD4
Catalytic activity : Enzyme6.3.2.- [ Enzyme-Expasy ]   6.3.2.- [ Enzyme-SRS ]   6.3.2.- [ IntEnz-EBI ]   6.3.2.- [ BRENDA ]   6.3.2.- [ KEGG ]   
Chemical/Protein Interactions : CTD4734
Chemical/Pharm GKB GenePA31533
Clinical trialNEDD4
Cancer Resource (Charite)ENSG00000069869
Ontology : AmiGOubiquitin ligase complex  chromatin  adaptive immune response  outflow tract morphogenesis  endocardial cushion development  ubiquitin-protein ligase activity  protein binding  nucleus  cytoplasm  Golgi apparatus  cytosol  cytosol  plasma membrane  plasma membrane  cell cortex  protein monoubiquitination  protein targeting to lysosome  lysosomal transport  neuromuscular junction development  negative regulation of sodium ion transport  negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage  positive regulation of phosphatidylinositol 3-kinase cascade  apicolateral plasma membrane  virus-host interaction  transmission of virus  cytokine-mediated signaling pathway  sodium channel inhibitor activity  protein domain specific binding  negative regulation of vascular endothelial growth factor receptor signaling pathway  neuron projection development  receptor internalization  beta-2 adrenergic receptor binding  receptor catabolic process  cellular response to UV  regulation of ion transmembrane transport  T cell activation  regulation of membrane potential  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  glucocorticoid receptor signaling pathway  ubiquitin binding  ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway  development involved in symbiotic interaction  positive regulation of protein catabolic process  positive regulation of nucleocytoplasmic transport  perinuclear region of cytoplasm  blood vessel morphogenesis  regulation of dendrite morphogenesis  regulation of synapse organization  phosphoserine binding  phosphothreonine binding  progesterone receptor signaling pathway  response to calcium ion  RNA polymerase binding  proline-rich region binding  proline-rich region binding  protein K63-linked ubiquitination  regulation of potassium ion transmembrane transporter activity  
Ontology : EGO-EBIubiquitin ligase complex  chromatin  adaptive immune response  outflow tract morphogenesis  endocardial cushion development  ubiquitin-protein ligase activity  protein binding  nucleus  cytoplasm  Golgi apparatus  cytosol  cytosol  plasma membrane  plasma membrane  cell cortex  protein monoubiquitination  protein targeting to lysosome  lysosomal transport  neuromuscular junction development  negative regulation of sodium ion transport  negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage  positive regulation of phosphatidylinositol 3-kinase cascade  apicolateral plasma membrane  virus-host interaction  transmission of virus  cytokine-mediated signaling pathway  sodium channel inhibitor activity  protein domain specific binding  negative regulation of vascular endothelial growth factor receptor signaling pathway  neuron projection development  receptor internalization  beta-2 adrenergic receptor binding  receptor catabolic process  cellular response to UV  regulation of ion transmembrane transport  T cell activation  regulation of membrane potential  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  glucocorticoid receptor signaling pathway  ubiquitin binding  ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway  development involved in symbiotic interaction  positive regulation of protein catabolic process  positive regulation of nucleocytoplasmic transport  perinuclear region of cytoplasm  blood vessel morphogenesis  regulation of dendrite morphogenesis  regulation of synapse organization  phosphoserine binding  phosphothreonine binding  progesterone receptor signaling pathway  response to calcium ion  RNA polymerase binding  proline-rich region binding  proline-rich region binding  protein K63-linked ubiquitination  regulation of potassium ion transmembrane transporter activity  
Pathways : KEGGUbiquitin mediated proteolysis
Other databases
Probes
Litterature
PubMed177 Pubmed reference(s) in Entrez
PubGeneNEDD4
iHOPNEDD4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 14 17:57:47 CEST 2013
Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.