NEIL2 (nei like DNA glycosylase 2)

2003-12-01  

Identity

HGNC
NEIL2
LOCATION
8p23.1
LOCUSID
252969
ALIAS
NEH2,NEI2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 252969
MIM: 608933
HGNC: 18956
Ensembl: ENSG00000154328

Variants:

dbSNP: 252969
ClinVar: 252969
TCGA: ENSG00000154328
COSMIC: NEIL2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000154328ENST00000284503Q969S2
ENSG00000154328ENST00000284503A0A024R361
ENSG00000154328ENST00000403422Q969S2
ENSG00000154328ENST00000436750Q969S2
ENSG00000154328ENST00000436750A0A024R361
ENSG00000154328ENST00000455213Q969S2
ENSG00000154328ENST00000455213A0A024R361
ENSG00000154328ENST00000528113E9PPL4
ENSG00000154328ENST00000528323Q969S2

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Base excision repairKEGGko03410
Base excision repairKEGGhsa03410
DNA RepairREACTOMER-HSA-73894
Base Excision RepairREACTOMER-HSA-73884
Base-Excision Repair, AP Site FormationREACTOMER-HSA-73929
DepyrimidinationREACTOMER-HSA-73928
Recognition and association of DNA glycosylase with site containing an affected pyrimidineREACTOMER-HSA-110328
Cleavage of the damaged pyrimidineREACTOMER-HSA-110329
Resolution of Abasic Sites (AP sites)REACTOMER-HSA-73933
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement PathwayREACTOMER-HSA-5649702

References

Pubmed IDYearTitleCitations
145229902003Repair of oxidized bases in DNA bubble structures by human DNA glycosylases NEIL1 and NEIL2.144
147345542004Differential specificity of human and Escherichia coli endonuclease III and VIII homologues for oxidative base lesions.52
176867772007Stimulation of NEIL2-mediated oxidized base excision repair via YB-1 interaction during oxidative stress.51
270044052016Genomic landscape of DNA repair genes in cancer.40
221306632012Role of human DNA glycosylase Nei-like 2 (NEIL2) and single strand break repair protein polynucleotide kinase 3'-phosphatase in maintenance of mitochondrial genome.36
170296392006Evaluation of NTHL1, NEIL1, NEIL2, MPG, TDG, UNG and SMUG1 genes in familial colorectal cancer predisposition.25
208197782010MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer.21
267516442016Neil DNA glycosylases promote substrate turnover by Tdg during DNA demethylation.21
185154112008Inherited predisposition to colorectal adenomas caused by multiple rare alleles of MUTYH but not OGG1, NUDT1, NTH1 or NEIL 1, 2 or 3.16
185940182008Functional variants of the NEIL1 and NEIL2 genes and risk and progression of squamous cell carcinoma of the oral cavity and oropharynx.13

Citation

Dessen P

NEIL2 (nei like DNA glycosylase 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/41520/neil2