NEK1 (NIMA related kinase 1)

2006-10-01  

Identity

HGNC
LOCATION
4q33
LOCUSID
ALIAS
ALS24,NY-REN-55,SRPS2,SRPS2A,SRTD6
FUSION GENES

Other Information

Locus ID:

NCBI: 4750
MIM: 604588
HGNC: 7744
Ensembl: ENSG00000137601

Variants:

dbSNP: 4750
ClinVar: 4750
TCGA: ENSG00000137601
COSMIC: NEK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000137601ENST00000439128Q96PY6
ENSG00000137601ENST00000505119H0Y8M6
ENSG00000137601ENST00000507142Q96PY6
ENSG00000137601ENST00000510108D6RBG5
ENSG00000137601ENST00000510533Q96PY6
ENSG00000137601ENST00000511633Q96PY6
ENSG00000137601ENST00000512193Q96PY6

Expression (GTEx)

0
10
20
30
40
50
60
70

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
212116172011NEK1 mutations cause short-rib polydactyly syndrome type majewski.72
274553472016NEK1 variants confer susceptibility to amyotrophic lateral sclerosis.55
269458852016NEK1 mutations in familial amyotrophic lateral sclerosis.35
188431992008Never-in-mitosis related kinase 1 functions in DNA damage response and checkpoint control.34
213012262011Nek1 kinase functions in DNA damage response and checkpoint control through a pathway independent of ATM and ATR.30
156042342004NIMA-related protein kinase 1 is involved early in the ionizing radiation-induced DNA damage response.29
146904472003Identification of proteins that interact with the central coiled-coil region of the human protein kinase NEK1.28
272648702016Nek1 Regulates Rad54 to Orchestrate Homologous Recombination and Replication Fork Stability.28
233454342013Nek1 kinase associates with ATR-ATRIP and primes ATR for efficient DNA damage signaling.27
205015472010Nek1 silencing slows down DNA repair and blocks DNA damage-induced cell cycle arrest.22

Citation

Dessen P

NEK1 (NIMA related kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43369/nek1