NEK3 (NIMA related kinase 3)

2003-11-01  

Identity

HGNC
NEK3
LOCATION
13q14.3
LOCUSID
4752
ALIAS
HSPK36
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4752
MIM: 604044
HGNC: 7746
Ensembl: ENSG00000136098

Variants:

dbSNP: 4752
ClinVar: 4752
TCGA: ENSG00000136098
COSMIC: NEK3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136098ENST00000550841F8VV00
ENSG00000136098ENST00000551355F8VTT4
ENSG00000136098ENST00000610828P51956
ENSG00000136098ENST00000611833P51956
ENSG00000136098ENST00000617054A0A087X203
ENSG00000136098ENST00000618534P51956
ENSG00000136098ENST00000618856A0A087X030
ENSG00000136098ENST00000620675A0A087WY58
ENSG00000136098ENST00000629912F8VTT4

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
172974582007Nek3 kinase regulates prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells.36
217562492011EHD2 mediates trafficking from the plasma membrane by modulating Rac1 activity.11
274891102016Identification of NEK3 Kinase Threonine 165 as a Novel Regulatory Phosphorylation Site That Modulates Focal Adhesion Remodeling Necessary for Breast Cancer Cell Migration.6
120633962001Molecular cloning and characterization of the human NIMA-related protein kinase 3 gene (NEK3).5
171187782006Is there any association between nek3 and cancers with frequent 13q14 deletion?4
295049922018Overexpression of NEK3 is associated with poor prognosis in patients with gastric cancer.3
319068782020Expression of the NEK family in normal and cancer tissue: an immunohistochemical study.2
294549642018NEK3-mediated SNAP29 phosphorylation modulates its membrane association and SNARE fusion dependent processes.1

Citation

Dessen P

NEK3 (NIMA related kinase 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41521/nek3