NEK6 (NIMA related kinase 6)

2006-10-01  

Identity

HGNC
LOCATION
9q33.3
LOCUSID
ALIAS
SID6-1512
FUSION GENES

Other Information

Locus ID:

NCBI: 10783
MIM: 604884
HGNC: 7749
Ensembl: ENSG00000119408

Variants:

dbSNP: 10783
ClinVar: 10783
TCGA: ENSG00000119408
COSMIC: NEK6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000119408ENST00000320246Q9HC98
ENSG00000119408ENST00000320246A0A024R8A6
ENSG00000119408ENST00000373596Q5TBG1
ENSG00000119408ENST00000373600Q9HC98
ENSG00000119408ENST00000373603Q9HC98
ENSG00000119408ENST00000373603A0A024R8A6
ENSG00000119408ENST00000394199Q9HC98
ENSG00000119408ENST00000422297Q5TBH2
ENSG00000119408ENST00000423785Q5TBG4
ENSG00000119408ENST00000425237Q5TBH1
ENSG00000119408ENST00000444973Q5TBG7
ENSG00000119408ENST00000447379Q5TBG2
ENSG00000119408ENST00000454453Q5TBH0
ENSG00000119408ENST00000539416Q9HC98
ENSG00000119408ENST00000540326Q9HC98
ENSG00000119408ENST00000545174Q9HC98
ENSG00000119408ENST00000545174A0A024R8A6
ENSG00000119408ENST00000546191Q9HC98
ENSG00000119408ENST00000546191A0A024R8A6

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic ProphaseREACTOMER-HSA-68875
Nuclear Envelope BreakdownREACTOMER-HSA-2980766
Activation of NIMA Kinases NEK9, NEK6, NEK7REACTOMER-HSA-2980767
Nuclear Pore Complex (NPC) DisassemblyREACTOMER-HSA-3301854

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
128400242003A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases.60
194145962009The Nek6 and Nek7 protein kinases are required for robust mitotic spindle formation and cytokinesis.60
216429572011Nek9 is a Plk1-activated kinase that controls early centrosome separation through Nek6/7 and Eg5.57
145638482003The serine/threonine kinase Nek6 is required for cell cycle progression through mitosis.39
210993612010Nek6 overexpression antagonizes p53-induced senescence in human cancer cells.23
120239602002Molecular basis for the substrate specificity of NIMA-related kinase-6 (NEK6). Evidence that NEK6 does not phosphorylate the hydrophobic motif of ribosomal S6 protein kinase and serum- and glucocorticoid-induced protein kinase in vivo.20
187283932008Nek6 is involved in G2/M phase cell cycle arrest through DNA damage-induced phosphorylation.20
208737832010Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome.20
259403452015Hsp72 is targeted to the mitotic spindle by Nek6 to promote K-fiber assembly and mitotic progression.19

Citation

Dessen P

NEK6 (NIMA related kinase 6)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43374/nek6