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NEK8 (NIMA related kinase 8)

Identity

Alias_namesNIMA (never in mitosis gene a)- related kinase 8
Alias_symbol (synonym)NPHP9
Other aliasJCK
NEK12A
RHPD2
HGNC (Hugo) NEK8
LocusID (NCBI) 284086
Atlas_Id 43376
Location 17q11.2  [Link to chromosome band 17q11]
Location_base_pair Starts at 28728814 and ends at 28742766 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FAM222B (17q11.2) / NEK8 (17q11.2)RAB34 (17q11.2) / NEK8 (17q11.2)TLCD1 (17q11.2) / NEK8 (17q11.2)
C17orf63 NEK8 17q11.2TLCD1 17q11.2 / NEK8 17q11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  FAM222B/NEK8 (17q11)
TLCD1/NEK8 (17q11)

External links

Nomenclature
HGNC (Hugo)NEK8   13387
Cards
Entrez_Gene (NCBI)NEK8  284086  NIMA related kinase 8
AliasesJCK; NEK12A; NPHP9; RHPD2
GeneCards (Weizmann)NEK8
Ensembl hg19 (Hinxton)ENSG00000160602 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000160602 [Gene_View]  ENSG00000160602 [Sequence]  chr17:28728814-28742766 [Contig_View]  NEK8 [Vega]
ICGC DataPortalENSG00000160602
TCGA cBioPortalNEK8
AceView (NCBI)NEK8
Genatlas (Paris)NEK8
WikiGenes284086
SOURCE (Princeton)NEK8
Genetics Home Reference (NIH)NEK8
Genomic and cartography
GoldenPath hg38 (UCSC)NEK8  -     chr17:28728814-28742766 +  17q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NEK8  -     17q11.2   [Description]    (hg19-Feb_2009)
GoldenPathNEK8 - 17q11.2 [CytoView hg19]  NEK8 - 17q11.2 [CytoView hg38]
ImmunoBaseENSG00000160602
Mapping of homologs : NCBINEK8 [Mapview hg19]  NEK8 [Mapview hg38]
OMIM609799   613824   615415   
Gene and transcription
Genbank (Entrez)AK301429 AL833909 AY242354 AY267371 BC112240
RefSeq transcript (Entrez)NM_178170
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NEK8
Cluster EST : UnigeneHs.574403 [ NCBI ]
CGAP (NCI)Hs.574403
Alternative Splicing GalleryENSG00000160602
Gene ExpressionNEK8 [ NCBI-GEO ]   NEK8 [ EBI - ARRAY_EXPRESS ]   NEK8 [ SEEK ]   NEK8 [ MEM ]
Gene Expression Viewer (FireBrowse)NEK8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)284086
GTEX Portal (Tissue expression)NEK8
Human Protein AtlasENSG00000160602-NEK8 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86SG6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86SG6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86SG6
Splice isoforms : SwissVarQ86SG6
PhosPhoSitePlusQ86SG6
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)    RCC1_3 (PS50012)   
Domains : Interpro (EBI)Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    RCC1/BLIP-II    Reg_chr_condens    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)    RCC1 (PF00415)   
Domain families : Pfam (NCBI)pfam00069    pfam00415   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)NEK8
DMDM Disease mutations284086
Blocks (Seattle)NEK8
SuperfamilyQ86SG6
Human Protein Atlas [tissue]ENSG00000160602-NEK8 [tissue]
Peptide AtlasQ86SG6
HPRD14822
IPIIPI00328397   IPI00908967   
Protein Interaction databases
DIP (DOE-UCLA)Q86SG6
IntAct (EBI)Q86SG6
FunCoupENSG00000160602
BioGRIDNEK8
STRING (EMBL)NEK8
ZODIACNEK8
Ontologies - Pathways
QuickGOQ86SG6
Ontology : AmiGOprotein serine/threonine kinase activity  protein binding  ATP binding  cytoplasm  cytoskeleton  cilium  cilium  cilium  protein phosphorylation  determination of left/right symmetry  heart development  animal organ morphogenesis  animal organ morphogenesis  regulation of hippo signaling  metal ion binding  cilium assembly  ciliary inversin compartment  ciliary base  
Ontology : EGO-EBIprotein serine/threonine kinase activity  protein binding  ATP binding  cytoplasm  cytoskeleton  cilium  cilium  cilium  protein phosphorylation  determination of left/right symmetry  heart development  animal organ morphogenesis  animal organ morphogenesis  regulation of hippo signaling  metal ion binding  cilium assembly  ciliary inversin compartment  ciliary base  
NDEx NetworkNEK8
Atlas of Cancer Signalling NetworkNEK8
Wikipedia pathwaysNEK8
Orthology - Evolution
OrthoDB284086
GeneTree (enSembl)ENSG00000160602
Phylogenetic Trees/Animal Genes : TreeFamNEK8
HOGENOMQ86SG6
Homologs : HomoloGeneNEK8
Homology/Alignments : Family Browser (UCSC)NEK8
Gene fusions - Rearrangements
Fusion : MitelmanFAM222B/NEK8 [17q11.2/17q11.2]  [t(17;17)(q11;q11)]  
Fusion : MitelmanTLCD1/NEK8 [17q11.2/17q11.2]  [t(17;17)(q11;q11)]  
Fusion PortalC17orf63 NEK8 17q11.2 OV
Fusion PortalTLCD1 17q11.2 NEK8 17q11.2 LUAD
Fusion : QuiverNEK8
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNEK8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NEK8
dbVarNEK8
ClinVarNEK8
1000_GenomesNEK8 
Exome Variant ServerNEK8
ExAC (Exome Aggregation Consortium)ENSG00000160602
GNOMAD BrowserENSG00000160602
Varsome BrowserNEK8
Genetic variants : HAPMAP284086
Genomic Variants (DGV)NEK8 [DGVbeta]
DECIPHERNEK8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNEK8 
Mutations
ICGC Data PortalNEK8 
TCGA Data PortalNEK8 
Broad Tumor PortalNEK8
OASIS PortalNEK8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNEK8  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNEK8
Mutations and Diseases : HGMDNEK8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Eye diseases - LOVD
BioMutasearch NEK8
DgiDB (Drug Gene Interaction Database)NEK8
DoCM (Curated mutations)NEK8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NEK8 (select a term)
intoGenNEK8
Cancer3DNEK8(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609799    613824    615415   
Orphanet20908    12426   
DisGeNETNEK8
MedgenNEK8
Genetic Testing Registry NEK8
NextProtQ86SG6 [Medical]
TSGene284086
GENETestsNEK8
Target ValidationNEK8
Huge Navigator NEK8 [HugePedia]
snp3D : Map Gene to Disease284086
BioCentury BCIQNEK8
ClinGenNEK8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD284086
Chemical/Pharm GKB GenePA38361
Clinical trialNEK8
Miscellaneous
canSAR (ICR)NEK8 (select the gene name)
DataMed IndexNEK8
Probes
Litterature
PubMed29 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNEK8
EVEXNEK8
GoPubMedNEK8
iHOPNEK8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Wed Nov 13 17:57:46 CET 2019
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