NEK9 (NIMA related kinase 9)

2006-10-01  

Identity

HGNC
LOCATION
14q24.3
LOCUSID
ALIAS
APUG,LCCS10,NC,NERCC,NERCC1
FUSION GENES

Other Information

Locus ID:

NCBI: 91754
MIM: 609798
HGNC: 18591
Ensembl: ENSG00000119638

Variants:

dbSNP: 91754
ClinVar: 91754
TCGA: ENSG00000119638
COSMIC: NEK9

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000119638ENST00000238616Q8TD19
ENSG00000119638ENST00000553823G3V5V0
ENSG00000119638ENST00000553945G3V5V6
ENSG00000119638ENST00000554258G3V459
ENSG00000119638ENST00000557673G3V2Z5

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic ProphaseREACTOMER-HSA-68875
Nuclear Envelope BreakdownREACTOMER-HSA-2980766
Activation of NIMA Kinases NEK9, NEK6, NEK7REACTOMER-HSA-2980767
Nuclear Pore Complex (NPC) DisassemblyREACTOMER-HSA-3301854

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
338195392022Three novel pathogenic NEK9 variants in patients with nevus comedonicus: A case series.0
359353242022Study on the Expression of lncRNA ATB and Nek9 in Breast Cancer Patients Based on Q-PCR Technology and Its Relationship with the Disease.0
362663402022NIMA-related kinase 9 regulates the phosphorylation of the essential myosin light chain in the heart.1
338195392022Three novel pathogenic NEK9 variants in patients with nevus comedonicus: A case series.0
359353242022Study on the Expression of lncRNA ATB and Nek9 in Breast Cancer Patients Based on Q-PCR Technology and Its Relationship with the Disease.0
362663402022NIMA-related kinase 9 regulates the phosphorylation of the essential myosin light chain in the heart.1
335007362021NEK9, a novel effector of IL-6/STAT3, regulates metastasis of gastric cancer by targeting ARHGEF2 phosphorylation.17
336648692021The short isoform of PRLR suppresses the pentose phosphate pathway and nucleotide synthesis through the NEK9-Hippo axis in pancreatic cancer.21
335007362021NEK9, a novel effector of IL-6/STAT3, regulates metastasis of gastric cancer by targeting ARHGEF2 phosphorylation.17
336648692021The short isoform of PRLR suppresses the pentose phosphate pathway and nucleotide synthesis through the NEK9-Hippo axis in pancreatic cancer.21
318573742020NIMA-related kinase 9-mediated phosphorylation of the microtubule-associated LC3B protein at Thr-50 suppresses selective autophagy of p62/sequestosome 1.21
320986872020Decreased Nek9 expression correlates with aggressive behaviour and predicts unfavourable prognosis in breast cancer.9
321842612020EML4-ALK V3 oncogenic fusion proteins promote microtubule stabilization and accelerated migration through NEK9 and NEK7.25
318573742020NIMA-related kinase 9-mediated phosphorylation of the microtubule-associated LC3B protein at Thr-50 suppresses selective autophagy of p62/sequestosome 1.21
320986872020Decreased Nek9 expression correlates with aggressive behaviour and predicts unfavourable prognosis in breast cancer.9

Citation

Dessen P

NEK9 (NIMA related kinase 9)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43377/nek9