NEK9 (NIMA related kinase 9)

2006-10-01  

Identity

HGNC
LOCATION
14q24.3
LOCUSID
ALIAS
APUG,LCCS10,NC,NERCC,NERCC1
FUSION GENES

Other Information

Locus ID:

NCBI: 91754
MIM: 609798
HGNC: 18591
Ensembl: ENSG00000119638

Variants:

dbSNP: 91754
ClinVar: 91754
TCGA: ENSG00000119638
COSMIC: NEK9

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000119638ENST00000238616Q8TD19
ENSG00000119638ENST00000553823G3V5V0
ENSG00000119638ENST00000553945G3V5V6
ENSG00000119638ENST00000554258G3V459
ENSG00000119638ENST00000557673G3V2Z5

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic ProphaseREACTOMER-HSA-68875
Nuclear Envelope BreakdownREACTOMER-HSA-2980766
Activation of NIMA Kinases NEK9, NEK6, NEK7REACTOMER-HSA-2980767
Nuclear Pore Complex (NPC) DisassemblyREACTOMER-HSA-3301854

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
128400242003A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases.60
121011232002Nercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progression.57
216429572011Nek9 is a Plk1-activated kinase that controls early centrosome separation through Nek6/7 and Eg5.57
199418172009An autoinhibitory tyrosine motif in the cell-cycle-regulated Nek7 kinase is released through binding of Nek9.40
228189142012Nek9 phosphorylation of NEDD1/GCP-WD contributes to Plk1 control of γ-tubulin recruitment to the mitotic centrosome.28
269560522016Survival kinase genes present prognostic significance in glioblastoma.21
146605632004Nek9, a novel FACT-associated protein, modulates interphase progression.20
205089832011Centrosome-related genes, genetic variation, and risk of breast cancer.16
265221582015Mechanistic basis of Nek7 activation through Nek9 binding and induced dimerization.14
214547042011DYNLL/LC8 protein controls signal transduction through the Nek9/Nek6 signaling module by regulating Nek6 binding to Nek9.13

Citation

Dessen P

NEK9 (NIMA related kinase 9)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43377/nek9