NELFB (negative elongation factor complex member B)

2007-02-01  

Identity

HGNC
LOCATION
9q34.3
LOCUSID
ALIAS
COBRA1,NELF-B
FUSION GENES

Other Information

Locus ID:

NCBI: 25920
MIM: 611180
HGNC: 24324
Ensembl: ENSG00000188986

Variants:

dbSNP: 25920
ClinVar: 25920
TCGA: ENSG00000188986
COSMIC: NELFB

RNA/Proteins

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
HIV InfectionREACTOMER-HSA-162906
HIV Life CycleREACTOMER-HSA-162587
Late Phase of HIV Life CycleREACTOMER-HSA-162599
Transcription of the HIV genomeREACTOMER-HSA-167172
HIV Transcription ElongationREACTOMER-HSA-167169
Formation of the HIV-1 Early Elongation ComplexREACTOMER-HSA-167158
Tat-mediated elongation of the HIV-1 transcriptREACTOMER-HSA-167246
Formation of HIV-1 elongation complex containing HIV-1 TatREACTOMER-HSA-167200
Abortive elongation of HIV-1 transcript in the absence of TatREACTOMER-HSA-167242
HIV elongation arrest and recoveryREACTOMER-HSA-167287
Formation of HIV elongation complex in the absence of HIV TatREACTOMER-HSA-167152
Pausing and recovery of HIV elongationREACTOMER-HSA-167290
Tat-mediated HIV elongation arrest and recoveryREACTOMER-HSA-167243
Pausing and recovery of Tat-mediated HIV elongationREACTOMER-HSA-167238
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
RNA Polymerase II TranscriptionREACTOMER-HSA-73857
RNA Polymerase II Pre-transcription EventsREACTOMER-HSA-674695
RNA Polymerase II Transcription ElongationREACTOMER-HSA-75955
Formation of the Early Elongation ComplexREACTOMER-HSA-113418
Formation of RNA Pol II elongation complexREACTOMER-HSA-112382
TP53 Regulates Transcription of DNA Repair GenesREACTOMER-HSA-6796648

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
174990422007NELF interacts with CBC and participates in 3' end processing of replication-dependent histone mRNAs.100
126120622003Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complex.86
174426802007Negative elongation factor NELF represses human immunodeficiency virus transcription by pausing the RNA polymerase II complex.57
179100362008Deregulation of cofactor of BRCA1 expression in breast cancer cells.18
176598692007Cofactor of BRCA1 modulates androgen-dependent transcription and alternative splicing.16
272823912016Architecture and RNA binding of the human negative elongation factor.15
164521882006Cofactor of BRCA1: a novel transcription factor regulator in upper gastrointestinal adenocarcinomas.13
180715892007Concerted transcriptional regulation by BRCA1 and COBRA1 in breast cancer cells.11
240979892013A conserved protein motif is required for full modulatory activity of negative elongation factor subunits NELF-A and NELF-B in modifying glucocorticoid receptor-regulated gene induction properties.9
155304302004COBRA1 inhibits AP-1 transcriptional activity in transfected cells.6

Citation

Dessen P

NELFB (negative elongation factor complex member B)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46321/nelfb