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NELFB (negative elongation factor complex member B)

Identity

Alias_namesCOBRA1
cofactor of BRCA1
Alias_symbol (synonym)KIAA1182
NELF-B
Other alias
HGNC (Hugo) NELFB
LocusID (NCBI) 25920
Atlas_Id 46321
Location 9q34.3  [Link to chromosome band 9q34]
Location_base_pair Starts at 137255300 and ends at 137273548 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
OS9 (12q13.3) / NELFB (9q34.3)RASA2 (3q23) / NELFB (9q34.3)TUBB4B (9q34.3) / NELFB (9q34.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(3;9)(q23;q34) RASA2/NELFB
TUBB4B/NELFB (9q34)

External links

Nomenclature
HGNC (Hugo)NELFB   24324
Cards
Entrez_Gene (NCBI)NELFB  25920  negative elongation factor complex member B
AliasesCOBRA1; NELF-B
GeneCards (Weizmann)NELFB
Ensembl hg19 (Hinxton)ENSG00000188986 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000188986 [Gene_View]  ENSG00000188986 [Sequence]  chr9:137255300-137273548 [Contig_View]  NELFB [Vega]
ICGC DataPortalENSG00000188986
TCGA cBioPortalNELFB
AceView (NCBI)NELFB
Genatlas (Paris)NELFB
WikiGenes25920
SOURCE (Princeton)NELFB
Genetics Home Reference (NIH)NELFB
Genomic and cartography
GoldenPath hg38 (UCSC)NELFB  -     chr9:137255300-137273548 +  9q34.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NELFB  -     9q34.3   [Description]    (hg19-Feb_2009)
GoldenPathNELFB - 9q34.3 [CytoView hg19]  NELFB - 9q34.3 [CytoView hg38]
ImmunoBaseENSG00000188986
Mapping of homologs : NCBINELFB [Mapview hg19]  NELFB [Mapview hg38]
OMIM611180   
Gene and transcription
Genbank (Entrez)AB033008 AF464935 AK022651 AK091056 AL050280
RefSeq transcript (Entrez)NM_015456
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NELFB
Cluster EST : UnigeneHs.521809 [ NCBI ]
CGAP (NCI)Hs.521809
Alternative Splicing GalleryENSG00000188986
Gene ExpressionNELFB [ NCBI-GEO ]   NELFB [ EBI - ARRAY_EXPRESS ]   NELFB [ SEEK ]   NELFB [ MEM ]
Gene Expression Viewer (FireBrowse)NELFB [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)25920
GTEX Portal (Tissue expression)NELFB
Human Protein AtlasENSG00000188986-NELFB [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8WX92   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8WX92  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8WX92
Splice isoforms : SwissVarQ8WX92
PhosPhoSitePlusQ8WX92
Domains : Interpro (EBI)COBRA1   
Domain families : Pfam (Sanger)COBRA1 (PF06209)   
Domain families : Pfam (NCBI)pfam06209   
Conserved Domain (NCBI)NELFB
DMDM Disease mutations25920
Blocks (Seattle)NELFB
SuperfamilyQ8WX92
Human Protein Atlas [tissue]ENSG00000188986-NELFB [tissue]
Peptide AtlasQ8WX92
HPRD10845
IPIIPI00103483   
Protein Interaction databases
DIP (DOE-UCLA)Q8WX92
IntAct (EBI)Q8WX92
FunCoupENSG00000188986
BioGRIDNELFB
STRING (EMBL)NELFB
ZODIACNELFB
Ontologies - Pathways
QuickGOQ8WX92
Ontology : AmiGORNA binding  protein binding  nucleoplasm  nucleoplasm  cytoplasm  transcription by RNA polymerase II  transcription elongation from RNA polymerase II promoter  cell proliferation  NELF complex  NELF complex  negative regulation of transcription elongation from RNA polymerase II promoter  negative regulation of transcription elongation from RNA polymerase II promoter  stem cell differentiation  positive regulation of viral transcription  negative regulation of stem cell differentiation  
Ontology : EGO-EBIRNA binding  protein binding  nucleoplasm  nucleoplasm  cytoplasm  transcription by RNA polymerase II  transcription elongation from RNA polymerase II promoter  cell proliferation  NELF complex  NELF complex  negative regulation of transcription elongation from RNA polymerase II promoter  negative regulation of transcription elongation from RNA polymerase II promoter  stem cell differentiation  positive regulation of viral transcription  negative regulation of stem cell differentiation  
NDEx NetworkNELFB
Atlas of Cancer Signalling NetworkNELFB
Wikipedia pathwaysNELFB
Orthology - Evolution
OrthoDB25920
GeneTree (enSembl)ENSG00000188986
Phylogenetic Trees/Animal Genes : TreeFamNELFB
HOGENOMQ8WX92
Homologs : HomoloGeneNELFB
Homology/Alignments : Family Browser (UCSC)NELFB
Gene fusions - Rearrangements
Fusion : MitelmanRASA2/NELFB [3q23/9q34.3]  [t(3;9)(q23;q34)]  
Fusion : MitelmanTUBB4B/NELFB [9q34.3/9q34.3]  [t(9;9)(q34;q34)]  
Fusion : QuiverNELFB
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNELFB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NELFB
dbVarNELFB
ClinVarNELFB
1000_GenomesNELFB 
Exome Variant ServerNELFB
ExAC (Exome Aggregation Consortium)ENSG00000188986
GNOMAD BrowserENSG00000188986
Varsome BrowserNELFB
Genetic variants : HAPMAP25920
Genomic Variants (DGV)NELFB [DGVbeta]
DECIPHERNELFB [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNELFB 
Mutations
ICGC Data PortalNELFB 
TCGA Data PortalNELFB 
Broad Tumor PortalNELFB
OASIS PortalNELFB [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNELFB  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNELFB
Mutations and Diseases : HGMDNELFB
BioMutasearch NELFB
DgiDB (Drug Gene Interaction Database)NELFB
DoCM (Curated mutations)NELFB (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NELFB (select a term)
intoGenNELFB
Cancer3DNELFB(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611180   
Orphanet
DisGeNETNELFB
MedgenNELFB
Genetic Testing Registry NELFB
NextProtQ8WX92 [Medical]
TSGene25920
GENETestsNELFB
Target ValidationNELFB
Huge Navigator NELFB [HugePedia]
snp3D : Map Gene to Disease25920
BioCentury BCIQNELFB
ClinGenNELFB
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD25920
Chemical/Pharm GKB GenePA162382703
Clinical trialNELFB
Miscellaneous
canSAR (ICR)NELFB (select the gene name)
DataMed IndexNELFB
Probes
Litterature
PubMed64 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNELFB
EVEXNELFB
GoPubMedNELFB
iHOPNELFB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Nov 13 17:57:47 CET 2019
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