NEURL4 (neuralized E3 ubiquitin protein ligase 4)

2014-11-01  

Identity

HGNC
NEURL4
LOCATION
17p13.1
LOCUSID
84461
ALIAS
-

Other Information

Locus ID:

NCBI: 84461
MIM: 615865
HGNC: 34410
Ensembl: ENSG00000215041

Variants:

dbSNP: 84461
ClinVar: 84461
TCGA: ENSG00000215041
COSMIC: NEURL4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000215041ENST00000315614Q96JN8
ENSG00000215041ENST00000399464Q96JN8
ENSG00000215041ENST00000570460I3L2W2
ENSG00000215041ENST00000571887I3L100
ENSG00000215041ENST00000573186I3L2Z9
ENSG00000215041ENST00000573651K7EPS7

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
222617222012Interaction proteomics identify NEURL4 and the HECT E3 ligase HERC2 as novel modulators of centrosome architecture.31
224416912012Neurl4, a novel daughter centriole protein, prevents formation of ectopic microtubule organizing centres.27
283859502017The daughter centriole controls ciliogenesis by regulating Neurl-4 localization at the centrosome.9

Citation

Dessen P

NEURL4 (neuralized E3 ubiquitin protein ligase 4)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/70805/neurl4