| Nomenclature |
|---|
| HGNC (Hugo) | NEUROD1 7762 |
| LRG (Locus Reference Genomic) | LRG_1119 |
| Cards |
|---|
| Entrez_Gene (NCBI) | NEUROD1 4760 neuronal differentiation 1 |
| Aliases | BETA2; BHF-1; MODY6; NEUROD; |
| bHLHa3 |
| GeneCards (Weizmann) | NEUROD1 |
| Ensembl hg19 (Hinxton) | ENSG00000162992 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000162992 [Gene_View] ENSG00000162992 [Sequence] chr2:181676106-181680665 [Contig_View] NEUROD1 [Vega] |
| ICGC DataPortal | ENSG00000162992 |
| TCGA cBioPortal | NEUROD1 |
| AceView (NCBI) | NEUROD1 |
| Genatlas (Paris) | NEUROD1 |
| WikiGenes | 4760 |
| SOURCE (Princeton) | NEUROD1 |
| Genetics Home Reference (NIH) | NEUROD1 |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | NEUROD1 - chr2:181676106-181680665 - 2q31.3 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | NEUROD1 - 2q31.3 [Description] (hg19-Feb_2009) |
| GoldenPath | NEUROD1 - 2q31.3 [CytoView hg19] NEUROD1 - 2q31.3 [CytoView hg38] |
| ImmunoBase | ENSG00000162992 |
| Mapping of homologs : NCBI | NEUROD1 [Mapview hg19] NEUROD1 [Mapview hg38] |
| OMIM | 125853 601724 606394 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AB593068 AB593069 AB593070 AB593071 AK313799 |
| RefSeq transcript (Entrez) | NM_002500 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | NEUROD1 |
| Cluster EST : Unigene | Hs.709709 [ NCBI ] |
| CGAP (NCI) | Hs.709709 |
| Alternative Splicing Gallery | ENSG00000162992 |
| Gene Expression | NEUROD1 [ NCBI-GEO ] NEUROD1 [ EBI - ARRAY_EXPRESS ]
NEUROD1 [ SEEK ] NEUROD1 [ MEM ] |
| Gene Expression Viewer (FireBrowse) | NEUROD1 [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevestigator | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 4760 |
| GTEX Portal (Tissue expression) | NEUROD1 |
| Human Protein Atlas | ENSG00000162992-NEUROD1 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | Q13562 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | Q13562 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | Q13562 |
| Splice isoforms : SwissVar | Q13562 |
| PhosPhoSitePlus | Q13562 |
| Domaine pattern : Prosite (Expaxy) | BHLH (PS50888) |
| Domains : Interpro (EBI) | bHLH_dom HLH_DNA-bd_sf Neurod1 Neurogenic_DUF TF_bHLH_NeuroD |
| Domain families : Pfam (Sanger) | HLH (PF00010) Neuro_bHLH (PF12533) |
| Domain families : Pfam (NCBI) | pfam00010 pfam12533 |
| Domain families : Smart (EMBL) | HLH (SM00353) |
| Conserved Domain (NCBI) | NEUROD1 |
| DMDM Disease mutations | 4760 |
| Blocks (Seattle) | NEUROD1 |
| Superfamily | Q13562 |
| Human Protein Atlas [tissue] | ENSG00000162992-NEUROD1 [tissue] |
| Peptide Atlas | Q13562 |
| HPRD | 03428 |
| IPI | IPI00299039 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | Q13562 |
| IntAct (EBI) | Q13562 |
| FunCoup | ENSG00000162992 |
| BioGRID | NEUROD1 |
| STRING (EMBL) | NEUROD1 |
| ZODIAC | NEUROD1 |
| Ontologies - Pathways |
|---|
| QuickGO | Q13562 |
| Ontology : AmiGO | DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II activating transcription factor binding DNA-binding transcription activator activity, RNA polymerase II-specific pancreatic A cell fate commitment pancreatic PP cell fate commitment chromatin binding DNA-binding transcription factor activity transcription coactivator activity protein binding nucleus nucleus nucleoplasm cytoplasm nucleocytoplasmic transport nitric oxide mediated signal transduction transcription factor binding response to glucose anterior/posterior pattern specification dentate gyrus development cerebellum development neurogenesis signal transduction involved in regulation of gene expression insulin secretion endocrine pancreas development endocrine pancreas development amacrine cell differentiation enteroendocrine cell differentiation response to drug glucose homeostasis positive regulation of apoptotic process sequence-specific DNA binding positive regulation of cell differentiation positive regulation of neuron differentiation positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II negative regulation of JAK-STAT cascade protein heterodimerization activity protein heterodimerization activity embryonic organ morphogenesis neuron development inner ear development regulation of insulin secretion positive regulation of DNA-binding transcription factor activity regulation of intestinal epithelial structure maintenance E-box binding regulation of cell cycle arrest cellular response to glucose stimulus RNA polymerase II transcription factor complex negative regulation of type B pancreatic cell apoptotic process positive regulation of transcription regulatory region DNA binding |
| Ontology : EGO-EBI | DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II activating transcription factor binding DNA-binding transcription activator activity, RNA polymerase II-specific pancreatic A cell fate commitment pancreatic PP cell fate commitment chromatin binding DNA-binding transcription factor activity transcription coactivator activity protein binding nucleus nucleus nucleoplasm cytoplasm nucleocytoplasmic transport nitric oxide mediated signal transduction transcription factor binding response to glucose anterior/posterior pattern specification dentate gyrus development cerebellum development neurogenesis signal transduction involved in regulation of gene expression insulin secretion endocrine pancreas development endocrine pancreas development amacrine cell differentiation enteroendocrine cell differentiation response to drug glucose homeostasis positive regulation of apoptotic process sequence-specific DNA binding positive regulation of cell differentiation positive regulation of neuron differentiation positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II negative regulation of JAK-STAT cascade protein heterodimerization activity protein heterodimerization activity embryonic organ morphogenesis neuron development inner ear development regulation of insulin secretion positive regulation of DNA-binding transcription factor activity regulation of intestinal epithelial structure maintenance E-box binding regulation of cell cycle arrest cellular response to glucose stimulus RNA polymerase II transcription factor complex negative regulation of type B pancreatic cell apoptotic process positive regulation of transcription regulatory region DNA binding |
| Pathways : KEGG | Maturity onset diabetes of the young |
| NDEx Network | NEUROD1 |
| Atlas of Cancer Signalling Network | NEUROD1 |
| Wikipedia pathways | NEUROD1 |
| Orthology - Evolution |
|---|
| OrthoDB | 4760 |
| GeneTree (enSembl) | ENSG00000162992 |
| Phylogenetic Trees/Animal Genes : TreeFam | NEUROD1 |
| HOGENOM | Q13562 |
| Homologs : HomoloGene | NEUROD1 |
| Homology/Alignments : Family Browser (UCSC) | NEUROD1 |
| Gene fusions - Rearrangements |
|---|
| Fusion : Quiver | NEUROD1 |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | NEUROD1 [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | NEUROD1 |
| dbVar | NEUROD1 |
| ClinVar | NEUROD1 |
| 1000_Genomes | NEUROD1 |
| Exome Variant Server | NEUROD1 |
| ExAC (Exome Aggregation Consortium) | ENSG00000162992 |
| GNOMAD Browser | ENSG00000162992 |
| Varsome Browser | NEUROD1 |
| Genetic variants : HAPMAP | 4760 |
| Genomic Variants (DGV) | NEUROD1 [DGVbeta] |
| DECIPHER | NEUROD1 [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | NEUROD1 |
| Mutations |
|---|
| ICGC Data Portal | NEUROD1 |
| TCGA Data Portal | NEUROD1 |
| Broad Tumor Portal | NEUROD1 |
| OASIS Portal | NEUROD1 [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | NEUROD1 [overview] [genome browser] [tissue] [distribution] |
| Somatic Mutations in Cancer : COSMIC3D | NEUROD1 |
| Mutations and Diseases : HGMD | NEUROD1 |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| LOVD (Leiden Open Variation Database) | MSeqDR-LSDB Mitochondrial Disease Locus Specific Database |
| BioMuta | search NEUROD1 |
| DgiDB (Drug Gene Interaction Database) | NEUROD1 |
| DoCM (Curated mutations) | NEUROD1 (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | NEUROD1 (select a term) |
| intoGen | NEUROD1 |
| Cancer3D | NEUROD1(select the gene name) |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 125853 601724 606394 |
| Orphanet | 8028 |
| DisGeNET | NEUROD1 |
| Medgen | NEUROD1 |
| Genetic Testing Registry | NEUROD1
|
| NextProt | Q13562 [Medical] |
| TSGene | 4760 |
| GENETests | NEUROD1 |
| Target Validation | NEUROD1 |
| Huge Navigator |
NEUROD1 [HugePedia] |
| snp3D : Map Gene to Disease | 4760 |
| BioCentury BCIQ | NEUROD1 |
| ClinGen | NEUROD1 |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 4760 |
| Chemical/Pharm GKB Gene | PA31564 |
| Clinical trial | NEUROD1 |
| Miscellaneous |
|---|
| canSAR (ICR) | NEUROD1 (select the gene name) |
| DataMed Index | NEUROD1 |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 110 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | NEUROD1 |
| EVEX | NEUROD1 |
| GoPubMed | NEUROD1 |
| iHOP | NEUROD1 |
