NEUROG3 (neurogenin 3)

2009-05-01 Affiliation

Identity

HGNC

NEUROG3

LOCATION

10q22.1

LOCUSID

50674

ALIAS

Atoh5,Math4B,NGN-3,bHLHa7,ngn3

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 50674
MIM: 604882
HGNC: 13806
Ensembl: ENSG00000122859

Variants:

dbSNP: 50674
ClinVar: 50674
TCGA: ENSG00000122859
COSMIC: NEUROG3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000122859	ENST00000242462	Q9Y4Z2

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Maturity onset diabetes of the young	KEGG	ko04950
Maturity onset diabetes of the young	KEGG	hsa04950
Developmental Biology	REACTOME	R-HSA-1266738
Regulation of beta-cell development	REACTOME	R-HSA-186712
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	REACTOME	R-HSA-210744
Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells	REACTOME	R-HSA-210746

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
12403815	2002	Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3.	76
18461161	2008	Post genome-wide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive value.	53
21099270	2009	Neurogenin3: a master regulator of pancreatic islet differentiation and regeneration.	46
21378176	2011	Permanent Neonatal Diabetes and Enteric Anendocrinosis Associated With Biallelic Mutations in NEUROG3.	43
17922104	2007	Notch signalling suppresses apoptosis in adult human and mouse pancreatic islet cells.	39
25650326	2015	The Basic Helix-Loop-Helix Transcription Factor NEUROG3 Is Required for Development of the Human Endocrine Pancreas.	28
19336475	2009	Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk.	27
28457793	2017	Multi-site Neurogenin3 Phosphorylation Controls Pancreatic Endocrine Differentiation.	24
29096722	2017	PDX1, Neurogenin-3, and MAFA: critical transcription regulators for beta cell development and regeneration.	24
22606327	2012	Plasticity of adult human pancreatic duct cells by neurogenin3-mediated reprogramming.	23

Citation

Dessen P

NEUROG3 (neurogenin 3)

Atlas Genet Cytogenet Oncol Haematol. 2009-05-01

Online version: http://atlasgeneticsoncology.org/gene/50918/neurog3