NFE2 (nuclear factor, erythroid 2)

2003-02-01  

Identity

HGNC
LOCATION
12q13.13
LOCUSID
ALIAS
NF-E2,p45
FUSION GENES

Other Information

Locus ID:

NCBI: 4778
MIM: 601490
HGNC: 7780
Ensembl: ENSG00000123405

Variants:

dbSNP: 4778
ClinVar: 4778
TCGA: ENSG00000123405
COSMIC: NFE2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000123405ENST00000312156Q16621
ENSG00000123405ENST00000312156A8K3E0
ENSG00000123405ENST00000435572Q16621
ENSG00000123405ENST00000435572A8K3E0
ENSG00000123405ENST00000540264Q16621
ENSG00000123405ENST00000540264A8K3E0
ENSG00000123405ENST00000553070Q16621
ENSG00000123405ENST00000553070A8K3E0
ENSG00000123405ENST00000553198F8W1N9

Expression (GTEx)

0
50
100
150
200
250
300
350

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199012662010NF-E2 domination over Nrf2 promotes ROS accumulation and megakaryocytic maturation.40
222313052012A novel murine model of myeloproliferative disorders generated by overexpression of the transcription factor NF-E2.28
202369332010USF and NF-E2 cooperate to regulate the recruitment and activity of RNA polymerase II in the beta-globin gene locus.24
228556092012Induction of functional platelets from mouse and human fibroblasts by p45NF-E2/Maf.24
203390922010AML1 is overexpressed in patients with myeloproliferative neoplasms and mediates JAK2V617F-independent overexpression of NF-E2.19
216099632011The distinctive roles of erythroid specific activator GATA-1 and NF-E2 in transcription of the human fetal γ-globin genes.16
235895692013MPN patients harbor recurrent truncating mutations in transcription factor NF-E2.16
284112672017NFE2 Induces miR-423-5p to Promote Gluconeogenesis and Hyperglycemia by Repressing the Hepatic FAM3A-ATP-Akt Pathway.15
167632112006A critical role for the transcription factor Scl in platelet production during stress thrombopoiesis.13
162878512005Sumoylation of p45/NF-E2: nuclear positioning and transcriptional activation of the mammalian beta-like globin gene locus.12

Citation

Dessen P

NFE2 (nuclear factor, erythroid 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41529/nfe2