NFE2L1 (nuclear factor, erythroid 2 like 1)

2013-04-01 Affiliation

Identity

HGNC

NFE2L1

LOCATION

17q21.32

LOCUSID

4779

ALIAS

LCR-F1,NRF1,TCF11

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 4779
MIM: 163260
HGNC: 7781
Ensembl: ENSG00000082641

Variants:

dbSNP: 4779
ClinVar: 4779
TCGA: ENSG00000082641
COSMIC: NFE2L1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000082641	ENST00000357480	Q14494
ENSG00000082641	ENST00000361665	J9JIE5
ENSG00000082641	ENST00000362042	Q14494
ENSG00000082641	ENST00000536222	F5H1B7
ENSG00000082641	ENST00000577411	J3KSR3
ENSG00000082641	ENST00000577431	J3QQQ1
ENSG00000082641	ENST00000579537	J3KSE0
ENSG00000082641	ENST00000579889	A0A0G2JLG9
ENSG00000082641	ENST00000580037	J3QQH8
ENSG00000082641	ENST00000580050	J3QRG7
ENSG00000082641	ENST00000581319	J3KRF3
ENSG00000082641	ENST00000582155	B4DYE1
ENSG00000082641	ENST00000583210	J3QR31
ENSG00000082641	ENST00000583378	J3QKY3
ENSG00000082641	ENST00000584137	J3QLQ1
ENSG00000082641	ENST00000584634	J3KTG6
ENSG00000082641	ENST00000585062	J3QQY8
ENSG00000082641	ENST00000585291	Q14494

Expression (GTEx)

100

200

300

400

500

600

700

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
20385086	2010	Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cells.	179
20932482	2010	Proteasomal degradation is transcriptionally controlled by TCF11 via an ERAD-dependent feedback loop.	130
24448410	2014	p97-dependent retrotranslocation and proteolytic processing govern formation of active Nrf1 upon proteasome inhibition.	71
27528193	2016	The aspartyl protease DDI2 activates Nrf1 to compensate for proteasome dysfunction.	43
17609210	2007	The p65 isoform of Nrf1 is a dominant negative inhibitor of ARE-mediated transcription.	29
21953459	2011	The Fbw7 tumor suppressor regulates nuclear factor E2-related factor 1 transcription factor turnover through proteasome-mediated proteolysis.	29
20237496	2010	New genetic associations detected in a host response study to hepatitis B vaccine.	27
22500024	2012	Nrf1 CNC-bZIP protein promotes cell survival and nucleotide excision repair through maintaining glutathione homeostasis.	24
23816881	2013	The casein kinase 2-nrf1 axis controls the clearance of ubiquitinated proteins by regulating proteasome gene expression.	21
26254094	2015	Changing gears in Nrf1 research, from mechanisms of regulation to its role in disease and prevention.	21

Citation

Dessen P

NFE2L1 (nuclear factor, erythroid 2 like 1)

Atlas Genet Cytogenet Oncol Haematol. 2013-04-01

Online version: http://atlasgeneticsoncology.org/gene/53247/nfe2l1