Atlas of Genetics and Cytogenetics in Oncology and Haematology

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NFE2L1 (nuclear factor, erythroid 2 like 1)

Identity

Alias_namesTCF11
nuclear factor (erythroid-derived 2)-like 1
nuclear factor, erythroid 2-like 1
Alias_symbol (synonym)NRF1
LCR-F1
FLJ00380
Other alias
HGNC (Hugo) NFE2L1
LocusID (NCBI) 4779
Atlas_Id 53247
Location 17q21.32  [Link to chromosome band 17q21]
Location_base_pair Starts at 48048324 and ends at 48061545 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ATXN1 (6p22.3) / NFE2L1 (17q21.32)HBA2 (16p13.3) / NFE2L1 (17q21.32)MICB (6p21.33) / NFE2L1 (17q21.32)
NFE2L1 (17q21.32) / CCDC36 (3p21.31)NFE2L1 (17q21.32) / EFHD1 (2q37.1)NFE2L1 (17q21.32) / NFE2L1 (17q21.32)
NFE2L1 (17q21.32) / PRKCSH (19p13.2)NFE2L1 (17q21.32) / SKAP1 (17q21.32)NFE2L1 (17q21.32) / SLC39A11 (17q24.3)
NFE2L1 (17q21.32) / TSPAN11 (12p11.21)NOS1 (12q24.22) / NFE2L1 (17q21.32)NFE2L1 17q21.32 / SLC39A11 17q24.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(17;17)(q21;q25) NFE2L1/SLC39A11

External links

Nomenclature
HGNC (Hugo)NFE2L1   7781
Cards
Entrez_Gene (NCBI)NFE2L1  4779  nuclear factor, erythroid 2 like 1
AliasesLCR-F1; NRF1; TCF11
GeneCards (Weizmann)NFE2L1
Ensembl hg19 (Hinxton)ENSG00000082641 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000082641 [Gene_View]  ENSG00000082641 [Sequence]  chr17:48048324-48061545 [Contig_View]  NFE2L1 [Vega]
ICGC DataPortalENSG00000082641
TCGA cBioPortalNFE2L1
AceView (NCBI)NFE2L1
Genatlas (Paris)NFE2L1
WikiGenes4779
SOURCE (Princeton)NFE2L1
Genetics Home Reference (NIH)NFE2L1
Genomic and cartography
GoldenPath hg38 (UCSC)NFE2L1  -     chr17:48048324-48061545 +  17q21.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NFE2L1  -     17q21.32   [Description]    (hg19-Feb_2009)
GoldenPathNFE2L1 - 17q21.32 [CytoView hg19]  NFE2L1 - 17q21.32 [CytoView hg38]
ImmunoBaseENSG00000082641
Mapping of homologs : NCBINFE2L1 [Mapview hg19]  NFE2L1 [Mapview hg38]
OMIM163260   
Gene and transcription
Genbank (Entrez)AK090459 AK294553 AK302387 AL530578 AL833530
RefSeq transcript (Entrez)NM_001330261 NM_001330262 NM_003204
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NFE2L1
Cluster EST : UnigeneHs.514284 [ NCBI ]
CGAP (NCI)Hs.514284
Alternative Splicing GalleryENSG00000082641
Gene ExpressionNFE2L1 [ NCBI-GEO ]   NFE2L1 [ EBI - ARRAY_EXPRESS ]   NFE2L1 [ SEEK ]   NFE2L1 [ MEM ]
Gene Expression Viewer (FireBrowse)NFE2L1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4779
GTEX Portal (Tissue expression)NFE2L1
Human Protein AtlasENSG00000082641-NFE2L1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14494   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14494  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14494
Splice isoforms : SwissVarQ14494
PhosPhoSitePlusQ14494
Domaine pattern : Prosite (Expaxy)BZIP (PS50217)    BZIP_BASIC (PS00036)   
Domains : Interpro (EBI)bZIP    bZIP_Maf    Nrf1_NFE2L1    TF_DNA-bd_sf   
Domain families : Pfam (Sanger)bZIP_Maf (PF03131)   
Domain families : Pfam (NCBI)pfam03131   
Domain families : Smart (EMBL)BRLZ (SM00338)  
Conserved Domain (NCBI)NFE2L1
DMDM Disease mutations4779
Blocks (Seattle)NFE2L1
SuperfamilyQ14494
Human Protein Atlas [tissue]ENSG00000082641-NFE2L1 [tissue]
Peptide AtlasQ14494
HPRD01223
IPIIPI00031017   IPI00414968   IPI01015922   IPI00376971   
Protein Interaction databases
DIP (DOE-UCLA)Q14494
IntAct (EBI)Q14494
FunCoupENSG00000082641
BioGRIDNFE2L1
STRING (EMBL)NFE2L1
ZODIACNFE2L1
Ontologies - Pathways
QuickGOQ14494
Ontology : AmiGOprotein polyubiquitination  transcription regulatory region sequence-specific DNA binding  RNA polymerase II distal enhancer sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  DNA-binding transcription factor activity  transcription coregulator activity  protein binding  nucleus  nucleus  cytoplasm  endoplasmic reticulum membrane  cytosol  fructose 6-phosphate metabolic process  transcription by RNA polymerase II  glutathione metabolic process  heme biosynthetic process  inflammatory response  regulation of mitotic nuclear division  cholesterol metabolic process  anatomical structure morphogenesis  regulation of glucose metabolic process  cholesterol binding  integral component of membrane  regulation of fatty acid metabolic process  cellular homeostasis  protein domain specific binding  spinal cord motor neuron differentiation  glial cell fate commitment  erythrocyte differentiation  protein-containing complex  cellular response to oxidative stress  response to endoplasmic reticulum stress  cholesterol homeostasis  cysteine transport  protein-containing complex binding  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  regulation of inflammatory response  glucose 6-phosphate metabolic process  regulation of proteasomal protein catabolic process  regulation of transcription from RNA polymerase II promoter in response to copper ion  cellular response to cold  cellular response to cholesterol  regulation of nucleus organization  regulation of response to endoplasmic reticulum stress  promoter-specific chromatin binding  
Ontology : EGO-EBIprotein polyubiquitination  transcription regulatory region sequence-specific DNA binding  RNA polymerase II distal enhancer sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  DNA-binding transcription factor activity  transcription coregulator activity  protein binding  nucleus  nucleus  cytoplasm  endoplasmic reticulum membrane  cytosol  fructose 6-phosphate metabolic process  transcription by RNA polymerase II  glutathione metabolic process  heme biosynthetic process  inflammatory response  regulation of mitotic nuclear division  cholesterol metabolic process  anatomical structure morphogenesis  regulation of glucose metabolic process  cholesterol binding  integral component of membrane  regulation of fatty acid metabolic process  cellular homeostasis  protein domain specific binding  spinal cord motor neuron differentiation  glial cell fate commitment  erythrocyte differentiation  protein-containing complex  cellular response to oxidative stress  response to endoplasmic reticulum stress  cholesterol homeostasis  cysteine transport  protein-containing complex binding  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  regulation of inflammatory response  glucose 6-phosphate metabolic process  regulation of proteasomal protein catabolic process  regulation of transcription from RNA polymerase II promoter in response to copper ion  cellular response to cold  cellular response to cholesterol  regulation of nucleus organization  regulation of response to endoplasmic reticulum stress  promoter-specific chromatin binding  
NDEx NetworkNFE2L1
Atlas of Cancer Signalling NetworkNFE2L1
Wikipedia pathwaysNFE2L1
Orthology - Evolution
OrthoDB4779
GeneTree (enSembl)ENSG00000082641
Phylogenetic Trees/Animal Genes : TreeFamNFE2L1
HOGENOMQ14494
Homologs : HomoloGeneNFE2L1
Homology/Alignments : Family Browser (UCSC)NFE2L1
Gene fusions - Rearrangements
Fusion : MitelmanNFE2L1/SLC39A11 [17q21.32/17q24.3]  
Fusion PortalNFE2L1 17q21.32 SLC39A11 17q24.3 SKCM
Fusion : QuiverNFE2L1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNFE2L1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NFE2L1
dbVarNFE2L1
ClinVarNFE2L1
1000_GenomesNFE2L1 
Exome Variant ServerNFE2L1
ExAC (Exome Aggregation Consortium)ENSG00000082641
GNOMAD BrowserENSG00000082641
Varsome BrowserNFE2L1
Genetic variants : HAPMAP4779
Genomic Variants (DGV)NFE2L1 [DGVbeta]
DECIPHERNFE2L1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNFE2L1 
Mutations
ICGC Data PortalNFE2L1 
TCGA Data PortalNFE2L1 
Broad Tumor PortalNFE2L1
OASIS PortalNFE2L1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNFE2L1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNFE2L1
Mutations and Diseases : HGMDNFE2L1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NFE2L1
DgiDB (Drug Gene Interaction Database)NFE2L1
DoCM (Curated mutations)NFE2L1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NFE2L1 (select a term)
intoGenNFE2L1
Cancer3DNFE2L1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM163260   
Orphanet
DisGeNETNFE2L1
MedgenNFE2L1
Genetic Testing Registry NFE2L1
NextProtQ14494 [Medical]
TSGene4779
GENETestsNFE2L1
Target ValidationNFE2L1
Huge Navigator NFE2L1 [HugePedia]
snp3D : Map Gene to Disease4779
BioCentury BCIQNFE2L1
ClinGenNFE2L1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4779
Chemical/Pharm GKB GenePA31587
Clinical trialNFE2L1
Miscellaneous
canSAR (ICR)NFE2L1 (select the gene name)
DataMed IndexNFE2L1
Probes
Litterature
PubMed70 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNFE2L1
EVEXNFE2L1
GoPubMedNFE2L1
iHOPNFE2L1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 17:57:54 CET 2019
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