Atlas of Genetics and Cytogenetics in Oncology and Haematology

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NFIC (nuclear factor I C)

Identity

Alias_namesNFI
nuclear factor I/C (CCAAT-binding transcription factor)
Alias_symbol (synonym)CTF
NF-I
CTF5
Other alias
HGNC (Hugo) NFIC
LocusID (NCBI) 4782
Atlas_Id 51783
Location 19p13.3  [Link to chromosome band 19p13]
Location_base_pair Starts at 3359563 and ends at 3469217 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARHGAP17 (16p12.1) / NFIC (19p13.3)FZR1 (19p13.3) / NFIC (19p13.3)GRID1 (10q23.1) / NFIC (19p13.3)
LRTOMT (11q13.4) / NFIC (19p13.3)NFIC (19p13.3) / C1orf186 (1q32.1)NFIC (19p13.3) / CELF5 (19p13.3)
NFIC (19p13.3) / NFIC (19p13.3)NFIC (19p13.3) / VSTM4 (10q11.23)NFIC (19p13.3) / WDR18 (19p13.3)
PIP5K1C (19p13.3) / NFIC (19p13.3)STK39 (2q24.3) / NFIC (19p13.3)TM6SF1 (15q25.2) / NFIC (19p13.3)
ZNF653 (19p13.2) / NFIC (19p13.3)FZR1 19p13.3 / NFIC 19p13.3LRTOMT 11q13.4 / NFIC 19p13.3
NFIC 19p13.3 / CELF5 19p13.3NFIC 19p13.3 / WDR18 19p13.3ZNF653 19p13.2 / NFIC 19p13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 7 ]
  t(11;19)(q13;p13) LRTOMT/NFIC
t(15;19)(q14;p13) RASGRP1/NFIC
t(16;19)(q24;p13) NFIC/SPATA33
FZR1/NFIC (19p13)
NFIC/CELF5 (19p13)
NFIC/WDR18 (19p13)
ZNF653/NFIC (19p13)

External links

Nomenclature
HGNC (Hugo)NFIC   7786
Cards
Entrez_Gene (NCBI)NFIC  4782  nuclear factor I C
AliasesCTF; CTF5; NF-I; NFI
GeneCards (Weizmann)NFIC
Ensembl hg19 (Hinxton)ENSG00000141905 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000141905 [Gene_View]  ENSG00000141905 [Sequence]  chr19:3359563-3469217 [Contig_View]  NFIC [Vega]
ICGC DataPortalENSG00000141905
TCGA cBioPortalNFIC
AceView (NCBI)NFIC
Genatlas (Paris)NFIC
WikiGenes4782
SOURCE (Princeton)NFIC
Genetics Home Reference (NIH)NFIC
Genomic and cartography
GoldenPath hg38 (UCSC)NFIC  -     chr19:3359563-3469217 +  19p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NFIC  -     19p13.3   [Description]    (hg19-Feb_2009)
GoldenPathNFIC - 19p13.3 [CytoView hg19]  NFIC - 19p13.3 [CytoView hg38]
ImmunoBaseENSG00000141905
Mapping of homologs : NCBINFIC [Mapview hg19]  NFIC [Mapview hg38]
OMIM600729   
Gene and transcription
Genbank (Entrez)AK129956 AK289885 AK297825 AK297867 AK304816
RefSeq transcript (Entrez)NM_001245002 NM_001245004 NM_001245005 NM_005597 NM_205843
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NFIC
Cluster EST : UnigeneHs.170131 [ NCBI ]
CGAP (NCI)Hs.170131
Alternative Splicing GalleryENSG00000141905
Gene ExpressionNFIC [ NCBI-GEO ]   NFIC [ EBI - ARRAY_EXPRESS ]   NFIC [ SEEK ]   NFIC [ MEM ]
Gene Expression Viewer (FireBrowse)NFIC [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4782
GTEX Portal (Tissue expression)NFIC
Human Protein AtlasENSG00000141905-NFIC [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP08651   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP08651  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP08651
Splice isoforms : SwissVarP08651
PhosPhoSitePlusP08651
Domaine pattern : Prosite (Expaxy)CTF_NFI_1 (PS00349)    CTF_NFI_2 (PS51080)   
Domains : Interpro (EBI)CTF/NFI    CTF/NFI_DNA-bd-dom    CTF/NFI_DNA-bd_CS    CTF/NFI_DNA-bd_N    MAD_homology1_Dwarfin-type   
Domain families : Pfam (Sanger)CTF_NFI (PF00859)    MH1 (PF03165)    NfI_DNAbd_pre-N (PF10524)   
Domain families : Pfam (NCBI)pfam00859    pfam03165    pfam10524   
Domain families : Smart (EMBL)DWA (SM00523)  
Conserved Domain (NCBI)NFIC
DMDM Disease mutations4782
Blocks (Seattle)NFIC
SuperfamilyP08651
Human Protein Atlas [tissue]ENSG00000141905-NFIC [tissue]
Peptide AtlasP08651
IPIIPI00029795   IPI00941207   IPI00218037   IPI00218039   IPI00218041   IPI01026493   IPI01015986   
Protein Interaction databases
DIP (DOE-UCLA)P08651
IntAct (EBI)P08651
FunCoupENSG00000141905
BioGRIDNFIC
STRING (EMBL)NFIC
ZODIACNFIC
Ontologies - Pathways
QuickGOP08651
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  negative regulation of transcription by RNA polymerase II  negative regulation of transcription by RNA polymerase II  RNA polymerase II proximal promoter sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  fibrillar center  DNA-binding transcription factor activity  nucleus  nucleus  DNA replication  transcription by RNA polymerase II  odontogenesis of dentin-containing tooth  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  negative regulation of transcription by RNA polymerase II  negative regulation of transcription by RNA polymerase II  RNA polymerase II proximal promoter sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  fibrillar center  DNA-binding transcription factor activity  nucleus  nucleus  DNA replication  transcription by RNA polymerase II  odontogenesis of dentin-containing tooth  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  
NDEx NetworkNFIC
Atlas of Cancer Signalling NetworkNFIC
Wikipedia pathwaysNFIC
Orthology - Evolution
OrthoDB4782
GeneTree (enSembl)ENSG00000141905
Phylogenetic Trees/Animal Genes : TreeFamNFIC
HOGENOMP08651
Homologs : HomoloGeneNFIC
Homology/Alignments : Family Browser (UCSC)NFIC
Gene fusions - Rearrangements
Fusion : MitelmanFZR1/NFIC [19p13.3/19p13.3]  [t(19;19)(p13;p13)]  
Fusion : MitelmanLRTOMT/NFIC [11q13.4/19p13.3]  [t(11;19)(q13;p13)]  
Fusion : MitelmanNFIC/CELF5 [19p13.3/19p13.3]  [t(19;19)(p13;p13)]  
Fusion : MitelmanNFIC/WDR18 [19p13.3/19p13.3]  [t(19;19)(p13;p13)]  
Fusion : MitelmanZNF653/NFIC [19p13.2/19p13.3]  [t(19;19)(p13;p13)]  
Fusion PortalFZR1 19p13.3 NFIC 19p13.3 BRCA
Fusion PortalLRTOMT 11q13.4 NFIC 19p13.3 BRCA
Fusion PortalNFIC 19p13.3 CELF5 19p13.3 LGG
Fusion PortalNFIC 19p13.3 WDR18 19p13.3 BRCA
Fusion PortalZNF653 19p13.2 NFIC 19p13.3 LUSC
Fusion : QuiverNFIC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNFIC [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NFIC
dbVarNFIC
ClinVarNFIC
1000_GenomesNFIC 
Exome Variant ServerNFIC
ExAC (Exome Aggregation Consortium)ENSG00000141905
GNOMAD BrowserENSG00000141905
Varsome BrowserNFIC
Genetic variants : HAPMAP4782
Genomic Variants (DGV)NFIC [DGVbeta]
DECIPHERNFIC [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNFIC 
Mutations
ICGC Data PortalNFIC 
TCGA Data PortalNFIC 
Broad Tumor PortalNFIC
OASIS PortalNFIC [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNFIC  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNFIC
Mutations and Diseases : HGMDNFIC
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NFIC
DgiDB (Drug Gene Interaction Database)NFIC
DoCM (Curated mutations)NFIC (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NFIC (select a term)
intoGenNFIC
Cancer3DNFIC(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600729   
Orphanet
DisGeNETNFIC
MedgenNFIC
Genetic Testing Registry NFIC
NextProtP08651 [Medical]
TSGene4782
GENETestsNFIC
Target ValidationNFIC
Huge Navigator NFIC [HugePedia]
snp3D : Map Gene to Disease4782
BioCentury BCIQNFIC
ClinGenNFIC
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4782
Chemical/Pharm GKB GenePA31592
Clinical trialNFIC
Miscellaneous
canSAR (ICR)NFIC (select the gene name)
DataMed IndexNFIC
Probes
Litterature
PubMed69 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNFIC
EVEXNFIC
GoPubMedNFIC
iHOPNFIC
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 17:57:55 CET 2019
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