NFKBIZ (NFKB inhibitor zeta)

2013-11-01  

Identity

HGNC
NFKBIZ
LOCATION
3q12.3
LOCUSID
64332
ALIAS
IKBZ,INAP,MAIL
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 64332
MIM: 608004
HGNC: 29805
Ensembl: ENSG00000144802

Variants:

dbSNP: 64332
ClinVar: 64332
TCGA: ENSG00000144802
COSMIC: NFKBIZ

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000144802ENST00000326151Q9BYH8
ENSG00000144802ENST00000326172Q9BYH8
ENSG00000144802ENST00000394054Q9BYH8
ENSG00000144802ENST00000461724C9J5G8
ENSG00000144802ENST00000477601H7C5S1
ENSG00000144802ENST00000483180C9JZ23
ENSG00000144802ENST00000491281C9J5I7

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
166220252006IL-1beta-specific up-regulation of neutrophil gelatinase-associated lipocalin is controlled by IkappaB-zeta.64
296702872018Electrophilic properties of itaconate and derivatives regulate the IκBζ-ATF3 inflammatory axis.64
156182162005Positive and negative regulation of nuclear factor-kappaB-mediated transcription by IkappaB-zeta, an inducible nuclear protein.46
165136452006A novel member of the IkappaB family, human IkappaB-zeta, inhibits transactivation of p65 and its DNA binding.44
183621422008Requirements for two proximal NF-kappaB binding sites and IkappaB-zeta in IL-17A-induced human beta-defensin 2 expression by conducting airway epithelium.38
174478952007Crucial roles of binding sites for NF-kappaB and C/EBPs in IkappaB-zeta-mediated transcriptional activation.30
188500102009The myxoid liposarcoma FUS-DDIT3 fusion oncoprotein deregulates NF-kappaB target genes by interaction with NFKBIZ.26
238690882013IκB-ζ controls the constitutive NF-κB target gene network and survival of ABC DLBCL.26
184362382008The nuclear I kappaB protein I kappaB zeta specifically binds NF-kappaB p50 homodimers and forms a ternary complex on kappaB DNA.23
212244762011IκBζ augments IL-12- and IL-18-mediated IFN-γ production in human NK cells.21

Citation

Dessen P

NFKBIZ (NFKB inhibitor zeta)

Atlas Genet Cytogenet Oncol Haematol. 2013-11-01

Online version: http://atlasgeneticsoncology.org/gene/53613/nfkbiz