NFYA (nuclear transcription factor Y subunit alpha)

2007-02-01  

Identity

HGNC
LOCATION
6p21.1
LOCUSID
ALIAS
CBF-A,CBF-B,HAP2,NF-YA
FUSION GENES

Other Information

Locus ID:

NCBI: 4800
MIM: 189903
HGNC: 7804
Ensembl: ENSG00000001167

Variants:

dbSNP: 4800
ClinVar: 4800
TCGA: ENSG00000001167
COSMIC: NFYA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000001167ENST00000341376P23511
ENSG00000001167ENST00000353205P23511
ENSG00000001167ENST00000353205A0A024RD22

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Antigen processing and presentationKEGGko04612
Antigen processing and presentationKEGGhsa04612
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
Metabolism of proteinsREACTOMER-HSA-392499
Unfolded Protein Response (UPR)REACTOMER-HSA-381119
ATF6 (ATF6-alpha) activates chaperonesREACTOMER-HSA-381033
ATF6 (ATF6-alpha) activates chaperone genesREACTOMER-HSA-381183
PERK regulates gene expressionREACTOMER-HSA-381042
ATF4 activates genesREACTOMER-HSA-380994
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)REACTOMER-HSA-400206
PPARA activates gene expressionREACTOMER-HSA-1989781
Regulation of cholesterol biosynthesis by SREBP (SREBF)REACTOMER-HSA-1655829
Activation of gene expression by SREBF (SREBP)REACTOMER-HSA-2426168

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
34762051987A multiplicity of CCAAT box-binding proteins.228
186546402008Genome-wide occupancy of SREBP1 and its partners NFY and SP1 reveals novel functional roles and combinatorial regulation of distinct classes of genes.95
233327512013Sequence-specific transcription factor NF-Y displays histone-like DNA binding and H2B-like ubiquitination.74
193514372009CCAAT/enhancer-binding protein beta: its role in breast cancer and associations with receptor tyrosine kinases.65
235952282013NF-Y coassociates with FOS at promoters, enhancers, repetitive elements, and inactive chromatin regions, and is stereo-positioned with growth-controlling transcription factors.51
156472792005Trichostatin A induces transforming growth factor beta type II receptor promoter activity and acetylation of Sp1 by recruitment of PCAF/p300 to a Sp1.NF-Y complex.47
117779302002BRCA1 regulates GADD45 through its interactions with the OCT-1 and CAAT motifs.45
145864022003p53-independent induction of Gadd45 by histone deacetylase inhibitor: coordinate regulation by transcription factors Oct-1 and NF-Y.45
160815372005NF-Ya activates multiple hematopoietic stem cell (HSC) regulatory genes and promotes HSC self-renewal.41
158476542005A flexible array format for large-scale, rapid blood group DNA typing.30

Citation

Dessen P

NFYA (nuclear transcription factor Y subunit alpha)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45601/nfya