Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 79840
MIM: 611290
HGNC: 25737
Ensembl: ENSG00000187736
Variants:
dbSNP: 79840
ClinVar: 79840
TCGA: ENSG00000187736
COSMIC: NHEJ1
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37256950 | 2023 | PAXX binding to the NHEJ machinery explains functional redundancy with XLF. | 6 |
| 37256950 | 2023 | PAXX binding to the NHEJ machinery explains functional redundancy with XLF. | 6 |
| 34056803 | 2021 | X-ray scattering reveals disordered linkers and dynamic interfaces in complexes and mechanisms for DNA double-strand break repair impacting cell and cancer biology. | 15 |
| 34244791 | 2021 | The conserved Tpk1 regulates non-homologous end joining double-strand break repair by phosphorylation of Nej1, a homolog of the human XLF. | 2 |
| 34352203 | 2021 | Cryo-EM of NHEJ supercomplexes provides insights into DNA repair. | 43 |
| 34056803 | 2021 | X-ray scattering reveals disordered linkers and dynamic interfaces in complexes and mechanisms for DNA double-strand break repair impacting cell and cancer biology. | 15 |
| 34244791 | 2021 | The conserved Tpk1 regulates non-homologous end joining double-strand break repair by phosphorylation of Nej1, a homolog of the human XLF. | 2 |
| 34352203 | 2021 | Cryo-EM of NHEJ supercomplexes provides insights into DNA repair. | 43 |
| 31259832 | 2020 | Combined Immunodeficiency, Hemolytic Anemia, and Growth Retardation Secondary to a Homozygous Mutation in the NHEJ1 Gene. | 2 |
| 31731258 | 2020 | Absence of XRCC4 and its paralogs in human cells reveal differences in outcomes for DNA repair and V(D)J recombination. | 9 |
| 31753920 | 2020 | The canonical non-homologous end joining factor XLF promotes chromosomal deletion rearrangements in human cells. | 10 |
| 31259832 | 2020 | Combined Immunodeficiency, Hemolytic Anemia, and Growth Retardation Secondary to a Homozygous Mutation in the NHEJ1 Gene. | 2 |
| 31731258 | 2020 | Absence of XRCC4 and its paralogs in human cells reveal differences in outcomes for DNA repair and V(D)J recombination. | 9 |
| 31753920 | 2020 | The canonical non-homologous end joining factor XLF promotes chromosomal deletion rearrangements in human cells. | 10 |
| 30579708 | 2019 | Synthetic lethality between DNA repair factors Xlf and Paxx is rescued by inactivation of Trp53. | 13 |
Citation
Dessen P
NHEJ1 (non-homologous end joining factor 1)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/45953/nhej1
