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NIBAN2 (niban apoptosis regulator 2)

Identity

Alias_namesC9orf88
FAM129B
chromosome 9 open reading frame 88
family with sequence similarity 129 member B
Alias_symbol (synonym)DKFZP434H0820
FLJ13518
FLJ22151
FLJ22298
bA356B19.6
MINERVA
Other aliasMEG-3
OC58
HGNC (Hugo) NIBAN2
LocusID (NCBI) 64855
Atlas_Id 50994
Location 9q34.11  [Link to chromosome band 9q34]
Location_base_pair Starts at 127505338 and ends at 127569117 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
C11orf75 FAM129B 9q33.3CNN1 19p13.2 / FAM129B 9q33.3FAM129B 9q33.3 / CLDN4 7q11.23
FAM129B 9q33.3 / OLFM1 9q34.3FAM129B 9q33.3 / PYROXD1 12p12.1FAM129B 9q33.3 / SEC16A 9q34.3
ZNF79 9q33.3 / FAM129B 9q33.3
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 7 ]
  t(7;9)(q11;q34) FAM129B/CLDN4
t(9;9)(q33;q34) ZNF79/FAM129B
FAM129B/OLFM1 (9q34)
FAM129B/SEC16A (9q34)
t(9;11)(q34;q21) SMCO4/FAM129B
t(9;12)(q34;p12) FAM129B/PYROXD1
t(9;19)(q34;p13) CNN1/FAM129B


External links

Nomenclature
HGNC (Hugo)NIBAN2   25282
Cards
Entrez_Gene (NCBI)NIBAN2  64855  niban apoptosis regulator 2
AliasesC9orf88; FAM129B; MEG-3; MINERVA; 
OC58; bA356B19.6
GeneCards (Weizmann)NIBAN2
Ensembl hg19 (Hinxton)ENSG00000136830 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000136830 [Gene_View]  ENSG00000136830 [Sequence]  chr9:127505338-127569117 [Contig_View]  NIBAN2 [Vega]
ICGC DataPortalENSG00000136830
TCGA cBioPortalNIBAN2
AceView (NCBI)NIBAN2
Genatlas (Paris)NIBAN2
WikiGenes64855
SOURCE (Princeton)NIBAN2
Genetics Home Reference (NIH)NIBAN2
Genomic and cartography
GoldenPath hg38 (UCSC)NIBAN2  -     chr9:127505338-127569117 -  -   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NIBAN2  -     -   [Description]    (hg19-Feb_2009)
GoldenPathNIBAN2 - - [CytoView hg19]  NIBAN2 - - [CytoView hg38]
ImmunoBaseENSG00000136830
Mapping of homologs : NCBINIBAN2 [Mapview hg19]  NIBAN2 [Mapview hg38]
OMIM614045   
Gene and transcription
Genbank (Entrez)AB210016 AF151783 AF192911 AK023580 AK025804
RefSeq transcript (Entrez)NM_001035534 NM_022833
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NIBAN2
Cluster EST : UnigeneHs.522401 [ NCBI ]
CGAP (NCI)Hs.522401
Alternative Splicing GalleryENSG00000136830
Gene ExpressionNIBAN2 [ NCBI-GEO ]   NIBAN2 [ EBI - ARRAY_EXPRESS ]   NIBAN2 [ SEEK ]   NIBAN2 [ MEM ]
Gene Expression Viewer (FireBrowse)NIBAN2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)64855
GTEX Portal (Tissue expression)NIBAN2
Human Protein AtlasENSG00000136830-NIBAN2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96TA1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96TA1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96TA1
Splice isoforms : SwissVarQ96TA1
PhosPhoSitePlusQ96TA1
Domaine pattern : Prosite (Expaxy)PH_DOMAIN (PS50003)   
Domains : Interpro (EBI)Niban-like    PH-like_dom_sf    PH_domain   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)NIBAN2
DMDM Disease mutations64855
Blocks (Seattle)NIBAN2
SuperfamilyQ96TA1
Human Protein Atlas [tissue]ENSG00000136830-NIBAN2 [tissue]
Peptide AtlasQ96TA1
HPRD10804
IPIIPI00647286   IPI00456750   IPI01015096   IPI00917117   
Protein Interaction databases
DIP (DOE-UCLA)Q96TA1
IntAct (EBI)Q96TA1
FunCoupENSG00000136830
BioGRIDNIBAN2
STRING (EMBL)NIBAN2
ZODIACNIBAN2
Ontologies - Pathways
QuickGOQ96TA1
Ontology : AmiGOtranscription coactivator activity  nucleus  nucleus  nucleoplasm  cytoplasm  cytosol  plasma membrane  adherens junction  axon guidance  negative regulation of cell proliferation  negative regulation of angiogenesis  cell differentiation  negative regulation of vascular endothelial growth factor receptor signaling pathway  gonadotropin secretion  gonadotropin secretion  positive regulation of embryonic development  negative regulation of apoptotic process  hypomethylation of CpG island  cadherin binding  negative regulation of Notch signaling pathway  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of skeletal muscle fiber development  extracellular exosome  negative regulation of DNA biosynthetic process  positive regulation of transcription regulatory region DNA binding  
Ontology : EGO-EBItranscription coactivator activity  nucleus  nucleus  nucleoplasm  cytoplasm  cytosol  plasma membrane  adherens junction  axon guidance  negative regulation of cell proliferation  negative regulation of angiogenesis  cell differentiation  negative regulation of vascular endothelial growth factor receptor signaling pathway  gonadotropin secretion  gonadotropin secretion  positive regulation of embryonic development  negative regulation of apoptotic process  hypomethylation of CpG island  cadherin binding  negative regulation of Notch signaling pathway  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of skeletal muscle fiber development  extracellular exosome  negative regulation of DNA biosynthetic process  positive regulation of transcription regulatory region DNA binding  
NDEx NetworkNIBAN2
Atlas of Cancer Signalling NetworkNIBAN2
Wikipedia pathwaysNIBAN2
Orthology - Evolution
OrthoDB64855
GeneTree (enSembl)ENSG00000136830
Phylogenetic Trees/Animal Genes : TreeFamNIBAN2
HOGENOMQ96TA1
Homologs : HomoloGeneNIBAN2
Homology/Alignments : Family Browser (UCSC)NIBAN2
Gene fusions - Rearrangements
Fusion : MitelmanCNN1/FAM129B [19p13.2/9q33.3]  [t(9;19)(q34;p13)]  
Fusion : MitelmanFAM129B/CLDN4 [9q33.3/7q11.23]  [t(7;9)(q11;q34)]  
Fusion : MitelmanFAM129B/OLFM1 [9q33.3/9q34.3]  [t(9;9)(q34;q34)]  
Fusion : MitelmanFAM129B/PYROXD1 [9q33.3/12p12.1]  [t(9;12)(q34;p12)]  
Fusion : MitelmanFAM129B/SEC16A [9q33.3/9q34.3]  [t(9;9)(q34;q34)]  
Fusion : MitelmanZNF79/FAM129B [9q33.3/9q33.3]  [t(9;9)(q33;q34)]  
Fusion PortalC11orf75 FAM129B 9q33.3 PRAD
Fusion PortalCNN1 19p13.2 FAM129B 9q33.3 PRAD
Fusion PortalFAM129B 9q33.3 CLDN4 7q11.23 PRAD
Fusion PortalFAM129B 9q33.3 OLFM1 9q34.3 BRCA
Fusion PortalFAM129B 9q33.3 PYROXD1 12p12.1 BRCA
Fusion PortalFAM129B 9q33.3 SEC16A 9q34.3 BRCA
Fusion PortalZNF79 9q33.3 FAM129B 9q33.3 BRCA
Fusion : QuiverNIBAN2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNIBAN2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NIBAN2
dbVarNIBAN2
ClinVarNIBAN2
1000_GenomesNIBAN2 
Exome Variant ServerNIBAN2
ExAC (Exome Aggregation Consortium)ENSG00000136830
GNOMAD BrowserENSG00000136830
Varsome BrowserNIBAN2
Genetic variants : HAPMAP64855
Genomic Variants (DGV)NIBAN2 [DGVbeta]
DECIPHERNIBAN2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNIBAN2 
Mutations
ICGC Data PortalNIBAN2 
TCGA Data PortalNIBAN2 
Broad Tumor PortalNIBAN2
OASIS PortalNIBAN2 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDNIBAN2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NIBAN2
DgiDB (Drug Gene Interaction Database)NIBAN2
DoCM (Curated mutations)NIBAN2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NIBAN2 (select a term)
intoGenNIBAN2
Cancer3DNIBAN2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM614045   
Orphanet
DisGeNETNIBAN2
MedgenNIBAN2
Genetic Testing Registry NIBAN2
NextProtQ96TA1 [Medical]
TSGene64855
GENETestsNIBAN2
Target ValidationNIBAN2
Huge Navigator NIBAN2 [HugePedia]
snp3D : Map Gene to Disease64855
BioCentury BCIQNIBAN2
ClinGenNIBAN2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD64855
Chemical/Pharm GKB GenePA162385984
Clinical trialNIBAN2
Miscellaneous
canSAR (ICR)NIBAN2 (select the gene name)
DataMed IndexNIBAN2
Probes
Litterature
PubMed35 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNIBAN2
EVEXNIBAN2
GoPubMedNIBAN2
iHOPNIBAN2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 17:58:01 CET 2019

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