NIT2 (nitrilase family member 2)

2003-06-01  

Identity

HGNC
LOCATION
3q12.2
LOCUSID
ALIAS
HEL-S-8a
FUSION GENES

Other Information

Locus ID:

NCBI: 56954
MIM: 616769
HGNC: 29878
Ensembl: ENSG00000114021

Variants:

dbSNP: 56954
ClinVar: 56954
TCGA: ENSG00000114021
COSMIC: NIT2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000114021ENST00000394140Q9NQR4
ENSG00000114021ENST00000394140V9HW91
ENSG00000114021ENST00000460317F8WF58
ENSG00000114021ENST00000480073F8WF70
ENSG00000114021ENST00000497785H7C579

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Alanine, aspartate and glutamate metabolismKEGGko00250
Alanine, aspartate and glutamate metabolismKEGGhsa00250
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
174882812007Growth inhibitory effect of the human NIT2 gene and its allelic imbalance in cancers.14
257387962015Downregulation of NIT2 inhibits colon cancer cell proliferation and induces cell cycle arrest through the caspase-3 and PARP pathways.9
226745782012Structural insights into the catalytic active site and activity of human Nit2/ω-amidase: kinetic assay and molecular dynamics simulation.3
250088472014Human nitrilase-like protein does not catalyze the hydrolysis of vildagliptin.1

Citation

Dessen P

NIT2 (nitrilase family member 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/41538/nit2