NKAP (NFKB activating protein)

2016-10-01  

Identity

HGNC
NKAP
LOCATION
Xq24
LOCUSID
79576
ALIAS
MRXSHD

Other Information

Locus ID:

NCBI: 79576
MIM: 300766
HGNC: 29873
Ensembl: ENSG00000101882

Variants:

dbSNP: 79576
ClinVar: 79576
TCGA: ENSG00000101882
COSMIC: NKAP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101882ENST00000371410Q8N5F7
ENSG00000101882ENST00000652253A0A494C050

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9
10
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
194098142009NKAP is a transcriptional repressor of notch signaling and is required for T cell development.43
216249372011NKAP is required for T cell maturation and acquisition of functional competency.32
145502612003Identification of a nuclear protein that promotes NF-kappaB activation.22
276948842016SUMOylated NKAP is essential for chromosome alignment by anchoring CENP-E to kinetochores.11
188049832009Association of genetic profiles to Crohn's disease by linear combinations of single nucleotide polymorphisms.1
312776842019NKAP alters tumor immune microenvironment and promotes glioma growth via Notch1 signaling.1
315454742019The oncogenic role of NKAP in the growth and invasion of colon cancer cells.0
315878682019Missense Mutations in NKAP Cause a Disorder of Transcriptional Regulation Characterized by Marfanoid Habitus and Cognitive Impairment.0

Citation

Dessen P

NKAP (NFKB activating protein)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56120/nkap