Atlas of Genetics and Cytogenetics in Oncology and Haematology

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NKD1 (NKD inhibitor of WNT signaling pathway 1)

Identity

Alias_namesnaked cuticle homolog 1 (Drosophila)
naked cuticle homolog 1
NKD1, WNT signaling pathway inhibitor
Other aliasNaked1
HGNC (Hugo) NKD1
LocusID (NCBI) 85407
Atlas_Id 51466
Location 16q12.1  [Link to chromosome band 16q12]
Location_base_pair Starts at 50548396 and ends at 50649249 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
KMT2A (11q23.3) / NKD1 (16q12.1)NKD1 (16q12.1) / ADCY7 (16q12.1)NKD1 (16q12.1) / LOC440354 ()

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(11;16)(q23;q12) KMT2A/NKD1

External links

Nomenclature
HGNC (Hugo)NKD1   17045
Cards
Entrez_Gene (NCBI)NKD1  85407  NKD inhibitor of WNT signaling pathway 1
AliasesNaked1
GeneCards (Weizmann)NKD1
Ensembl hg19 (Hinxton)ENSG00000140807 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000140807 [Gene_View]  ENSG00000140807 [Sequence]  chr16:50548396-50649249 [Contig_View]  NKD1 [Vega]
ICGC DataPortalENSG00000140807
TCGA cBioPortalNKD1
AceView (NCBI)NKD1
Genatlas (Paris)NKD1
WikiGenes85407
SOURCE (Princeton)NKD1
Genetics Home Reference (NIH)NKD1
Genomic and cartography
GoldenPath hg38 (UCSC)NKD1  -     chr16:50548396-50649249 +  16q12.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NKD1  -     16q12.1   [Description]    (hg19-Feb_2009)
GoldenPathNKD1 - 16q12.1 [CytoView hg19]  NKD1 - 16q12.1 [CytoView hg38]
Genome Data Viewer NCBINKD1 [Mapview hg19]  
OMIM607851   
Gene and transcription
Genbank (Entrez)AB062886 AF289584 AF358135 AK000276 AK021701
RefSeq transcript (Entrez)NM_033119
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NKD1
Alternative Splicing GalleryENSG00000140807
Gene ExpressionNKD1 [ NCBI-GEO ]   NKD1 [ EBI - ARRAY_EXPRESS ]   NKD1 [ SEEK ]   NKD1 [ MEM ]
Gene Expression Viewer (FireBrowse)NKD1 [ Firebrowse - Broad ]
GenevisibleExpression of NKD1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)85407
GTEX Portal (Tissue expression)NKD1
Human Protein AtlasENSG00000140807-NKD1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ969G9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ969G9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ969G9
Splice isoforms : SwissVarQ969G9
PhosPhoSitePlusQ969G9
Domaine pattern : Prosite (Expaxy)EF_HAND_1 (PS00018)    EF_HAND_2 (PS50222)   
Domains : Interpro (EBI)EF-hand-dom_pair    EF_Hand_1_Ca_BS    EF_hand_dom    Nkd-like   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)NKD1
DMDM Disease mutations85407
SuperfamilyQ969G9
Human Protein Atlas [tissue]ENSG00000140807-NKD1 [tissue]
Peptide AtlasQ969G9
HPRD08482
IPIIPI00056339   
Protein Interaction databases
DIP (DOE-UCLA)Q969G9
IntAct (EBI)Q969G9
FunCoupENSG00000140807
BioGRIDNKD1
STRING (EMBL)NKD1
ZODIACNKD1
Ontologies - Pathways
QuickGOQ969G9
Ontology : AmiGOprotein phosphatase type 2A complex  eye photoreceptor cell differentiation  calcium ion binding  protein binding  cytoplasm  plasma membrane  somatic muscle development  Wnt signaling pathway  PDZ domain binding  negative regulation of Wnt signaling pathway  positive regulation of protein catabolic process  negative regulation of canonical Wnt signaling pathway  negative regulation of canonical Wnt signaling pathway  regulation of cell motility involved in somitogenic axis elongation  positive regulation of non-canonical Wnt signaling pathway via JNK cascade  negative regulation of convergent extension involved in axis elongation  positive regulation of Wnt signaling pathway, planar cell polarity pathway  
Ontology : EGO-EBIprotein phosphatase type 2A complex  eye photoreceptor cell differentiation  calcium ion binding  protein binding  cytoplasm  plasma membrane  somatic muscle development  Wnt signaling pathway  PDZ domain binding  negative regulation of Wnt signaling pathway  positive regulation of protein catabolic process  negative regulation of canonical Wnt signaling pathway  negative regulation of canonical Wnt signaling pathway  regulation of cell motility involved in somitogenic axis elongation  positive regulation of non-canonical Wnt signaling pathway via JNK cascade  negative regulation of convergent extension involved in axis elongation  positive regulation of Wnt signaling pathway, planar cell polarity pathway  
Pathways : KEGGWnt signaling pathway    Hippo signaling pathway   
NDEx NetworkNKD1
Atlas of Cancer Signalling NetworkNKD1
Wikipedia pathwaysNKD1
Orthology - Evolution
OrthoDB85407
GeneTree (enSembl)ENSG00000140807
Phylogenetic Trees/Animal Genes : TreeFamNKD1
HOGENOMQ969G9
Homologs : HomoloGeneNKD1
Homology/Alignments : Family Browser (UCSC)NKD1
Gene fusions - Rearrangements
Fusion : QuiverNKD1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNKD1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NKD1
dbVarNKD1
ClinVarNKD1
1000_GenomesNKD1 
Exome Variant ServerNKD1
GNOMAD BrowserENSG00000140807
Varsome BrowserNKD1
Genetic variants : HAPMAP85407
Genomic Variants (DGV)NKD1 [DGVbeta]
DECIPHERNKD1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNKD1 
Mutations
ICGC Data PortalNKD1 
TCGA Data PortalNKD1 
Broad Tumor PortalNKD1
OASIS PortalNKD1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNKD1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNKD1
Mutations and Diseases : HGMDNKD1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutaselect NKD1
DgiDB (Drug Gene Interaction Database)NKD1
DoCM (Curated mutations)NKD1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NKD1 (select a term)
intoGenNKD1
Cancer3DNKD1 (select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607851   
Orphanet
DisGeNETNKD1
MedgenNKD1
Genetic Testing Registry NKD1
NextProtQ969G9 [Medical]
TSGene85407
GENETestsNKD1
Open Targets GeneticsENSG00000140807  [validation]
snp3D : Map Gene to Disease85407
BioCentury BCIQNKD1
ClinGenNKD1
Clinical trials, drugs, therapy
Protein Interactions : CTD85407
Pharm GKB GenePA31637
Clinical trialNKD1
Miscellaneous
canSAR (ICR)NKD1 (select the gene name)
HarmonizomeNKD1
DataMed IndexNKD1
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNKD1
EVEXNKD1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Jul 11 20:02:27 CEST 2020
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